Institution
Romanian Academy
Archive•Bucharest, Romania•
About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that several of the synthesized proligands and copper(II) complexes are effective antiproliferative agents in several cancer cell lines, targeting RNR, which deserve further investigation as potential anticancer drugs.
Abstract: As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 inhibitor, which has entered ∼20 clinical trials. Thiosemicarbazones are supposed to exert their biological effects through effectively binding transition-metal ions. In this study, six iminodiacetate–thiosemicarbazones able to form transition-metal complexes, as well as six dicopper(II) complexes, were synthesized and fully characterized by analytical, spectroscopic techniques (IR, UV–vis; 1H and 13C NMR), electrospray ionization mass spectrometry, and X-ray diffraction. The antiproliferative effects were examined in several human cancer and one noncancerous cell lines. Several of the compounds showed high cytotoxicity and marked selectivity for cancer cells. On the basis of this, and on molecular docking calculations one lead dicopper(II) complex and one thiosemicarbazone were chosen for in vitro analysis as potential R2 in...
48 citations
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TL;DR: In this article, it was shown that the space of mathematical instantons with second Chern class 5 over ℙ3 is smooth and irreducible, and simple proofs for the same statements in case of second Chern ≤ 4 are contained.
Abstract: We prove that the space of mathematical instantons with second Chern class 5 over ℙ3 is smooth and irreducible. Unified and simple proofs for the same statements in case of second Chern class ≤ 4 are contained.
48 citations
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TL;DR: In this paper, two polyurethane-epoxy maleate of bisphenol A networks were synthesized and their thermal behavior was studied, and the data obtained by thermogravimetry showed that the decomposition of the tested samples is complex, occurs in three steps, and depends on the degree of crosslinking.
48 citations
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TL;DR: A comparative study of the behavior of carboxymethyl cellulose and poly(N-isopropylacrylamide) (PNIPAM) as graft copolymers and physical blends, in solution and in solid state was performed by viscometry, turbidimetry, IR spectroscopy, X-ray diffraction, thermogravimetry and enzymatic degradation.
48 citations
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TL;DR: A series of ortho-metallated Pd and Pt complexes containing dimeric liquid crystals Schiff base as cyclometallated ligands and N -benzoyl thiourea derivatives as co-ligands were prepared and investigated for their liquid crystalline properties.
48 citations
Authors
Showing all 3740 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cristina Popescu | 74 | 285 | 18434 |
Adrian Covic | 73 | 570 | 17379 |
Gheorghe Paun | 65 | 399 | 18513 |
Floriana Tuna | 60 | 271 | 11968 |
Arto Salomaa | 56 | 374 | 17706 |
Jan A. Bergstra | 55 | 616 | 13436 |
Alexandru T. Balaban | 53 | 605 | 14225 |
Cristian Sminchisescu | 53 | 173 | 12268 |
Maya Simionescu | 47 | 192 | 10608 |
Marius Andruh | 46 | 239 | 8431 |
Werner Scheid | 46 | 518 | 9186 |
Vicenţiu D. Rădulescu | 46 | 360 | 7771 |
Cornelia Vasile | 44 | 297 | 7108 |
Irinel Popescu | 44 | 401 | 8448 |
Mihail Barboiu | 44 | 239 | 5789 |