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Institution

Romanian Academy

ArchiveBucharest, Romania
About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.


Papers
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Journal ArticleDOI
TL;DR: It is suggested that several of the synthesized proligands and copper(II) complexes are effective antiproliferative agents in several cancer cell lines, targeting RNR, which deserve further investigation as potential anticancer drugs.
Abstract: As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 inhibitor, which has entered ∼20 clinical trials. Thiosemicarbazones are supposed to exert their biological effects through effectively binding transition-metal ions. In this study, six iminodiacetate–thiosemicarbazones able to form transition-metal complexes, as well as six dicopper(II) complexes, were synthesized and fully characterized by analytical, spectroscopic techniques (IR, UV–vis; 1H and 13C NMR), electrospray ionization mass spectrometry, and X-ray diffraction. The antiproliferative effects were examined in several human cancer and one noncancerous cell lines. Several of the compounds showed high cytotoxicity and marked selectivity for cancer cells. On the basis of this, and on molecular docking calculations one lead dicopper(II) complex and one thiosemicarbazone were chosen for in vitro analysis as potential R2 in...

48 citations

Journal ArticleDOI
TL;DR: In this article, it was shown that the space of mathematical instantons with second Chern class 5 over ℙ3 is smooth and irreducible, and simple proofs for the same statements in case of second Chern ≤ 4 are contained.
Abstract: We prove that the space of mathematical instantons with second Chern class 5 over ℙ3 is smooth and irreducible. Unified and simple proofs for the same statements in case of second Chern class ≤ 4 are contained.

48 citations

Journal ArticleDOI
TL;DR: In this paper, two polyurethane-epoxy maleate of bisphenol A networks were synthesized and their thermal behavior was studied, and the data obtained by thermogravimetry showed that the decomposition of the tested samples is complex, occurs in three steps, and depends on the degree of crosslinking.

48 citations

Journal ArticleDOI
TL;DR: A comparative study of the behavior of carboxymethyl cellulose and poly(N-isopropylacrylamide) (PNIPAM) as graft copolymers and physical blends, in solution and in solid state was performed by viscometry, turbidimetry, IR spectroscopy, X-ray diffraction, thermogravimetry and enzymatic degradation.

48 citations

Journal ArticleDOI
TL;DR: A series of ortho-metallated Pd and Pt complexes containing dimeric liquid crystals Schiff base as cyclometallated ligands and N -benzoyl thiourea derivatives as co-ligands were prepared and investigated for their liquid crystalline properties.

48 citations


Authors

Showing all 3740 results

NameH-indexPapersCitations
Cristina Popescu7428518434
Adrian Covic7357017379
Gheorghe Paun6539918513
Floriana Tuna6027111968
Arto Salomaa5637417706
Jan A. Bergstra5561613436
Alexandru T. Balaban5360514225
Cristian Sminchisescu5317312268
Maya Simionescu4719210608
Marius Andruh462398431
Werner Scheid465189186
Vicenţiu D. Rădulescu463607771
Cornelia Vasile442977108
Irinel Popescu444018448
Mihail Barboiu442395789
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202335
2022113
2021671
2020690
2019704
2018630