Romanian Academy

About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.

Experimental investigations of cold-formed steel beams of corrugated web and built-up section for flanges

Abstract: The steel beams of corrugated web represent a relatively new structural system which emerged in the past two decades. The thin corrugated web affords a significant weight reduction of these beams, compared with hot-rolled or welded ones. In the solutions existing on the market, the flanges are made of flat plates welded to the sinusoidal web sheet, requiring a specific welding technology. A new solution is proposed in this paper, in which the beam is composed by a web of trapezoidal cold-formed steel sheet and flanges of built-up cold-formed steel members (e.g. back-to-back lipped channel sections or angles with turn lips). The connections between flanges and web can be done by self-drilling screws or by spot welding. The first part of the study, summarised in this paper, is devoted to the evaluation and validation of technical solution, including experimental investigations, carried out at the CEMSIG Research Centre of the Politehnica University of Timisoara ( http://www.ct.upt.ro/en/centre/cemsig ). In a subsequent paper, numerical investigations aiming to optimise the solution and estimate its technical limits for applications will be presented.

A weak compact jet in a soft state of Cygnus X‐1

Abstract: We present evidence for the presence of a weak compact jet during a soft X-ray state of Cygnus X-1. Very-high-resolution radio observations were taken with the VLBA, EVN and MERLIN during a hard-to-soft spectral state change, showing the hard state jet to be suppressed by a factor of about 35 in radio flux and unresolved to direct imaging observations (i.e. ?1 mas at 4 cm). High time-resolution X-ray observations with the RXTE-PCA were also taken during the radio monitoring period, showing the source to make the transition from the hard state to a softer state (via an intermediate state), although the source may never have reached the canonical soft state. Using astrometric very long baseline interferometry (VLBI) analysis and removing proper motion, parallax and orbital motion signatures, the residual positions show a scatter of similar to 0.2 mas (at 4 cm) and similar to 3 mas (at 13 cm) along the position angle of the known jet axis; these residuals suggest that there is a weak unresolved outflow, with varying size or opacity, during intermediate and soft X-ray states. Furthermore, no evidence was found for extended knots or shocks forming within the jet during the state transition, suggesting that the change in outflow rate may not be sufficiently high to produce superluminal knots.

A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7

Abstract: Precision in redox signaling is attained through posttranslational protein modifications such as oxidation of protein thiols. The peroxidase peroxiredoxin 1 (PRDX1) regulates signal transduction through changes in thiol oxidation of its cysteines. We demonstrate here that PRDX1 is a binding partner for the tumor suppressive transcription factor FOXO3 that directly regulates the FOXO3 stress response. Heightened oxidative stress evokes formation of disulfide-bound heterotrimers linking dimeric PRDX1 to monomeric FOXO3. Absence of PRDX1 enhances FOXO3 nuclear localization and transcription that are dependent on the presence of Cys31 or Cys150 within FOXO3. Notably, FOXO3-T32 phosphorylation is constitutively enhanced in these mutants, but nuclear translocation of mutant FOXO3 is restored with PI3K inhibition. Here we show that on H2O2 exposure, transcription of tumor suppressive miRNAs let-7b and let-7c is regulated by FOXO3 or PRDX1 expression levels and that let-7c is a novel target for FOXO3. Conjointly, inhibition of let-7 microRNAs increases let-7-phenotypes in PRDX1-deficient breast cancer cells. Altogether, these data ascertain the existence of an H2O2-sensitive PRDX1-FOXO3 signaling axis that fine tunes FOXO3 activity toward the transcription of gene targets in response to oxidative stress. Antioxid. Redox Signal. 28, 62-77.

On Sofic Actions and Equivalence Relations

Abstract: The notion of sofic equivalence relation was introduced by Gabor Elek and Gabor Lippner. Their technics employ some graph theory. Here we define this notion in a more operator algebraic context, starting from Connes' embedding problem, and prove the equivalence of this two definitions. We introduce a notion of sofic action for an arbitrary group and prove that amalgamated product of sofic actions over amenable groups is again sofic. We also prove that amalgamated product of sofic groups over an amenable subgroup is again sofic.