Romanian Academy

About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.

Computing with Cells and Atoms: An Introduction to Quantum, DNA and Membrane Computing

Abstract: 1. Prerequisites 1.1. Preliminary Notions and Notations 1.2. Operations on Strings and Languages 1.3. A General Computing Framework 1.4. Chomsky Grammars 1.5. Lindenmayer Systems 1.6. Automata and Transducers 1.7. Characterizations of Computably Enumerable Languages 1.8. Universal Turing Machines and Type-0 Grammars 1.9. Complexity 1.10. Bibliographic Notes 2. DNA Computing 2.1 The Structure of DNA 2.2. Complementarity Induces Computational Completeness 2.3. Operations on DNA Molecules 2.4. Adleman's Experiment 2.5. Other DNA Solutions to NP Complete Problems 2.6. A Two-dimensional Generalization 2.7. Computing by Carving 2.8. Sticker Systems 2.9 Extended H-Systems 2.10 Controlled H-Systems 2.11 Distributed H-Systems 2.12 Bibliographic Notes 3. Membrane Computing 3.1 P Systems with Labeled Membranes 3.2. Examples 3.3. The Power of P Systems 3.4. Decidability Results 3.5. Rewriting P Systms 3.6. P Systems with Polarized Membranes 3.7. Normal Forms 3.8. P Systems on Asymmetric Graphs 3.9. P Systems with Active Membranes 3.10. Splicing P Systems 3.11 Variants, Problems, Conjectures 3.12 Bibliographic Notes 4. Quantum Computing 4.1. Church-Turing Thesis 4.2 Computation is Physical 4.3. Reversible Computation 4.4. The Copy Computer 4.5. Maxwell's Demon 4.6. Quantum World 4.7 Bits and Quibits 4.8. Quantum Calculus 4.9. Quibit Evolution 4.10 No Cloning Theorem 4.11. Measurements 4.12 Zeno Machines 4.13 Inexhaustible Uncertainty 4.14. Randomness 4.15. The EPR Conundrum and Bell's Theorem 4.16. Quantum Logic 4.17. Have Quantum Propositions Classical Meaning? 4.18 Quantum Computers 4.19 Quantum Algorithms 4.20 Quantum Complexity 4.21 Quantum Cryptography 4.22 Information and Teleportation 4.23 Computing the Uncomputable 4.24 Bibliographic Notes 5. Final Remarks 6. Bibliography 7. Index

Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy

Abstract: Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients. However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN. Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury. Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation. Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early. Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN. The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN.

A Caenorhabditis elegans Wild Type Defies the Temperature-Size Rule Owing to a Single Nucleotide Polymorphism in tra-3

Abstract: Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower temperatures, a phenomenon known as the temperature–size rule. Since temperature affects virtually all processes in a living organism, current theories to explain this phenomenon are diverse and complex and assert often from opposing assumptions. Although widely studied, the molecular genetic control of the temperature–size rule is unknown. We found that the Caenorhabditis elegans wild-type N2 complied with the temperature–size rule, whereas wild-type CB4856 defied it. Using a candidate gene approach based on an N2 × CB4856 recombinant inbred panel in combination with mutant analysis, complementation, and transgenic studies, we show that a single nucleotide polymorphism in tra-3 leads to mutation F96L in the encoded calpain-like protease. This mutation attenuates the ability of CB4856 to grow larger at low temperature. Homology modelling predicts that F96L reduces TRA-3 activity by destabilizing the DII-A domain. The data show that size adaptation of ectotherms to temperature changes may be less complex than previously thought because a subtle wild-type polymorphism modulates the temperature responsiveness of body size. These findings provide a novel step toward the molecular understanding of the temperature–size rule, which has puzzled biologists for decades.

Statistical limit theorems for suspension flows

Abstract: In dynamical systems theory, a standard method for passing from discrete time to continuous time is to construct the suspension flow under a roof function. In this paper, we give conditions under which statistical laws, such as the central limit theorem and almost sure invariance principle, for the underlying discrete time system are inherited by the suspension flow. As a consequence, we give a simpler proof of the results of Ratner (1973) and recover the results of Denker and Philipp (1984) for Axiom A flows. Morcover, we obtain several new results for nonuniformly and partially hyperbolic flows, including frame flows on negatively curved manifolds satisfying a pinching condition.