Institution
Royal London Hospital
Healthcare•London, United Kingdom•
About: Royal London Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Poison control. The organization has 4854 authors who have published 5081 publications receiving 168207 citations. The organization is also known as: London Infirmary & London Hospital.
Topics: Population, Poison control, Intensive care, Transplantation, Cancer
Papers published on a yearly basis
Papers
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University of Bristol1, University of Oxford2, Churchill Hospital3, Wellcome Trust Centre for Human Genetics4, National Health Service5, University of London6, Imperial College London7, University of Oulu8, National Institutes of Health9, Medical Research Council10, Wellcome Trust Sanger Institute11, Newcastle University12, Queen Mary University of London13, Royal London Hospital14, University of Dundee15, Ninewells Hospital16
TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
Abstract: Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
4,184 citations
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TL;DR: A new type of endoscopy, which for the first time allows painless endoscopic imaging of the whole of the small bowel, is developed and successfully tested in humans.
Abstract: The discomfort of internal gastrointestinal examination may soon be a thing of the past. We have developed a new type of endoscopy, which for the first time allows painless endoscopic imaging of the whole of the small bowel. This procedure involves a wireless capsule endoscope and we describe here its successful testing in humans.
2,578 citations
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TL;DR: A modified and improved SCARE checklist is presented, after a Delphi consensus exercise was completed to update the SCARE guidelines.
2,195 citations
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TL;DR: The periaqueductal grey, the raphe nuclei and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord and it is clear from more recent work that NA has an equally important part to play.
Abstract: Thanks largely to the study of the brainstem nuclei that mediate stimulation analgesia, the involvement of the monoamines in the descending control of pain is now well established. The periaqueductal grey, the raphe nuclei (NRM and DRN) and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord. Although the initial emphasis was on 5-HT as the transmitter mediating this control at spinal levels, it is clear from more recent work that NA has an equally important part to play. How (or even if) the two amines differ in their roles and actions in analgesia is, however, still an open question. The small size and complexity of the brainstem areas from which analgesia may be elicited by electrical stimulation complicates the interpretation of the data. Stimulating currents may spread to surrounding regions mediating opposite effects to that of the main region stimulated. Opiates and GABA are clearly involved in descending control at both brainstem and spinal levels, although the relative roles of the different types of amino-acid and opiate receptors is still hotly debated. Despite the fact that the first report on stimulation analgesia appeared more than a quarter of a century ago in 1969, the precise connections and cord synaptology are still the basis of ongoing research. It is perhaps ironic, in an issue dedicated to new molecules and mechanisms, that those transmitters most involved in descending inhibition should be such old and familiar friends.
1,741 citations
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TL;DR: There is a clinical need for better methods to examine the small bowel especially in patients with recurrent gastrointestinal bleeding from this site, and small bowel endoscopy is currently especially limited by problems of discomfort and failure to advance enteroscopes far into theSmall bowel.
Abstract: Gastroscopy, small bowel endoscopy, and colonoscopy are uncomfortable because they require comparatively large diameter flexible cables to be pushed into the bowel, which carry light by fibreoptic bundles, power, and video signals. Small bowel endoscopy is currently especially limited by problems of discomfort and failure to advance enteroscopes far into the small bowel. There is a clinical need for better methods to examine the small bowel especially in patients with recurrent gastrointestinal bleeding from this site.
1,657 citations
Authors
Showing all 4863 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mark I. McCarthy | 200 | 1028 | 187898 |
Timothy G. Dinan | 116 | 689 | 60561 |
Nicola Maffulli | 115 | 1570 | 59548 |
Jonathan J Deeks | 109 | 381 | 131283 |
Ashley B. Grossman | 107 | 873 | 45941 |
Jadwiga A. Wedzicha | 104 | 505 | 49160 |
Khalid S. Khan | 92 | 684 | 33700 |
Irene M. Leigh | 91 | 366 | 29347 |
Gavin Giovannoni | 89 | 852 | 38443 |
Christoph Thiemermann | 89 | 474 | 28732 |
Ian Jacobs | 86 | 446 | 28485 |
James W. Ironside | 86 | 590 | 33745 |
Graham Roberts | 83 | 542 | 24822 |
Ezio Bonifacio | 82 | 357 | 22157 |
Peter Hoskin | 82 | 585 | 29453 |