Institution
Royal Netherlands Academy of Arts and Sciences
Government•Amsterdam, Netherlands•
About: Royal Netherlands Academy of Arts and Sciences is a government organization based out in Amsterdam, Netherlands. It is known for research contribution in the topics: Population & Stem cell. The organization has 1476 authors who have published 2315 publications receiving 139645 citations. The organization is also known as: KNAW & Koninklijke Nederlandse Akademie van Wetenschappen.
Topics: Population, Stem cell, Wnt signaling pathway, Organoid, Visual cortex
Papers published on a yearly basis
Papers
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TL;DR: A novel microglia type associated with neurodegenerative diseases (DAM) is described and it is revealed that the DAM program is activated in a two-step process that involves downregulation of microglian checkpoints, followed by activation of a Trem2-dependent program.
2,854 citations
TL;DR: A proposed standard protocol for describing IBMs and ABMs, developed and tested by 28 modellers who cover a wide range of fields within ecology, and considered as a first step for establishing a more detailed common format of the description of IBm and ABM.
2,633 citations
American Museum of Natural History1, University of Tartu2, University of Colombo3, Royal Netherlands Academy of Arts and Sciences4, University of Florida5, University of Palermo6, Goethe University Frankfurt7, Hobart Corporation8, Nakhon Phanom University9, University of Bamenda10, University of Gothenburg11, Naturalis12, Swedish University of Agricultural Sciences13, Royal Botanic Gardens14, Universiti Malaysia Sabah15, United States Department of Agriculture16, Forest Research Institute Malaysia17, Humboldt State University18, Chinese Academy of Sciences19, Landcare Research20, University of Western Australia21, Estonian University of Life Sciences22, University of Southern Queensland23, Botanic Garden Meise24, Manchester Metropolitan University25, James Cook University26
TL;DR: Diversity of most fungal groups peaked in tropical ecosystems, but ectomycorrhizal fungi and several fungal classes were most diverse in temperate or boreal ecosystems, and manyfungal groups exhibited distinct preferences for specific edaphic conditions (such as pH, calcium, or phosphorus).
Abstract: Fungi play major roles in ecosystem processes, but the determinants of fungal diversity and biogeographic patterns remain poorly understood. Using DNA metabarcoding data from hundreds of globally distributed soil samples, we demonstrate that fungal richness is decoupled from plant diversity. The plant-to-fungus richness ratio declines exponentially toward the poles. Climatic factors, followed by edaphic and spatial variables, constitute the best predictors of fungal richness and community composition at the global scale. Fungi show similar latitudinal diversity gradients to other organisms, with several notable exceptions. These findings advance our understanding of global fungal diversity patterns and permit integration of fungi into a general macroecological framework.
2,346 citations
TL;DR: 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina, and hold promise to predict drug response in a personalized fashion.
1,810 citations
TL;DR: This review attempts to summarize the underlying concepts of the notion that tumors are maintained by their own stem cells, to distinguish hard facts from beliefs and to define the future challenges of the field.
Abstract: Over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This review attempts to summarize the underlying concepts of this notion, to distinguish hard facts from beliefs and to define the future challenges of the field.
1,753 citations
Authors
Showing all 1485 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hans Clevers | 199 | 793 | 169673 |
| Pedro W. Crous | 115 | 809 | 51925 |
| Dick F. Swaab | 109 | 699 | 45574 |
| Jack J. Middelburg | 102 | 429 | 40067 |
| Jan P. Vandenbroucke | 101 | 508 | 84563 |
| Alexander van Oudenaarden | 101 | 229 | 45367 |
| Rainer Goebel | 99 | 443 | 33506 |
| Christine L. Mummery | 94 | 416 | 32296 |
| Pieter A. Doevendans | 93 | 590 | 32378 |
| Ruud M. Buijs | 87 | 228 | 23662 |
| Wim van den Brink | 85 | 473 | 23537 |
| Edwin Cuppen | 83 | 330 | 28862 |
| Peter M. J. Herman | 81 | 317 | 20558 |
| Robert A. Samson | 80 | 316 | 25030 |
| Caroline C W Klaver | 79 | 352 | 28651 |