Institution
Royan Institute
Nonprofit•Tehran, Iran•
About: Royan Institute is a nonprofit organization based out in Tehran, Iran. It is known for research contribution in the topics: Stem cell & Sperm. The organization has 1562 authors who have published 2774 publications receiving 48104 citations. The organization is also known as: Royan Institute for Reproductive Biomedicine, Stem Cell Biology and Technology.
Papers published on a yearly basis
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Clotilde Théry1, Kenneth W. Witwer2, Elena Aikawa3, María José Alcaraz4 +414 more•Institutions (209)
TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
Abstract: The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
5,988 citations
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TL;DR: PCL/gelatin 70:30 nanofiber was found to exhibit the most balanced properties to meet all the required specifications for nerve tissue and was used for in vitro culture of nerve stem cells and proved to be a promising biomaterial suitable for nerve regeneration.
1,010 citations
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TL;DR: Braveheart (Bvht), a heart-associated lncRNA in mouse is identified and it is found that Bvht is necessary for activation of a core cardiovascular gene network and functions upstream of mesoderm posterior 1 (MesP1), a master regulator of a common multipotent cardiovascular progenitor.
817 citations
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TL;DR: By taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering.
Abstract: Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(e-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.
571 citations
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University of Sheffield1, Newcastle upon Tyne Hospitals NHS Foundation Trust2, Agency for Science, Technology and Research3, Royan Institute4, Stanford University5, Boston Children's Hospital6, University of Nottingham7, University of Southern California8, Hebrew University of Jerusalem9, Tel Aviv Sourasky Medical Center10, Cedars-Sinai Medical Center11, University of Geneva12, Manchester Academic Health Science Centre13, University of Manchester14, Genome Institute of Singapore15, Seoul National University16, Harvard University17, University of Edinburgh18, Masaryk University19, WiCell20, University of São Paulo21, Central South University22, University College London23, Karolinska Institutet24, Jawaharlal Nehru Centre for Advanced Scientific Research25, Kyoto University26, Shanghai Jiao Tong University27, Kurchatov Institute28, Russian Academy of Sciences29, Vrije Universiteit Brussel30, King's College London31, Leiden University32, University of Helsinki33, Yale University34, Hospital for Sick Children35, University of New South Wales36, University of Tampere37, Commonwealth Scientific and Industrial Research Organisation38
TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.
Abstract: The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for genetic changes occurring during culture. Most lines were analyzed at an early and late passage. Single-nucleotide polymorphism (SNP) analysis revealed that they included representatives of most major ethnic groups. Most lines remained karyotypically normal, but there was a progressive tendency to acquire changes on prolonged culture, commonly affecting chromosomes 1, 12, 17 and 20. DNA methylation patterns changed haphazardly with no link to time in culture. Structural variants, determined from the SNP arrays, also appeared sporadically. No common variants related to culture were observed on chromosomes 1, 12 and 17, but a minimal amplicon in chromosome 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% of the lines. Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells.
506 citations
Authors
Showing all 1570 results
Name | H-index | Papers | Citations |
---|---|---|---|
Burkhard Becher | 78 | 248 | 25509 |
Hossein Baharvand | 56 | 454 | 15081 |
Christian Aalkjaer | 53 | 268 | 10875 |
Ghasem Hosseini Salekdeh | 48 | 233 | 11295 |
Mohammad Hossein Nasr-Esfahani | 44 | 389 | 9145 |
Morteza Hosseini | 42 | 298 | 6096 |
Mohammad Mahdi Hasani-Sadrabadi | 33 | 91 | 2752 |
Nasser Aghdami | 33 | 144 | 3342 |
Kamran Ghaedi | 32 | 292 | 4500 |
Mohammad Javan | 32 | 178 | 3240 |
Hamid Gourabi | 31 | 129 | 3191 |
Mehdi Mohamadnejad | 29 | 91 | 3235 |
Mohammad Hossein Sanati | 29 | 169 | 2570 |
Mohamadreza Baghaban Eslaminejad | 29 | 143 | 3112 |
Ramin Radpour | 29 | 64 | 2272 |