Showing papers by "Rush University Medical Center published in 1970"
TL;DR: L‐dopa ameliorates the symptoms of parkiusonism as a result of reinstitution of dopamine inhibition of the striatal neurons and the efficacy of amantadine hydrochloride is felt to be related to a block of the presynaptic reuptake of dopamine and thereby a prolongation of dopamine's effect at the receptor site.
Abstract: The production of all the major symptoms of parkinsonism is attributed chiefly to the loss of the normal dopaminergic input into the striatum. This loss of dopaminergic input is due to degeneration of the cell bodies of the substantia nigra. An analogous loss of serotonin (5-hydroxytryptamine) may be of significance in the production of parkinsonian tremor. L-dopa ameliorates the symptoms of parkiusonism as a result of reinstitution of dopamine inhibition of the striatal neurons. L-dopa induced dyskinesias are felt to be related to denervation hypersensitivity of striatal neurons to dopamine produced by dopaminergic denervation. Failure to respond to L-dopa is related to degeneration of striatal dopaminergic receptors. The efficacy of amantadine hydrochloride is felt to be related to a block of the presynaptic reuptake of dopamine and thereby a prolongation of dopamine's effect at the receptor site.
102 citations
TL;DR: The experiments reported in this paper were designed to explain the phenomenon that plasma Ep levels reach peak titers after 8 hours of hypoxia and then fall to barely detectable levels after 72 hours, suggesting that the initiation of increased erythropoiesis requires higher Ep levels than its maintenance during continued Hypoxia.
41 citations
24 citations
TL;DR: It was found that the mean protein concentration in the urine correlated with the altitude at which the samples were taken, and alterations in P/O ratio with changes in altitude were not caused by variations in exercise.
24 citations
TL;DR: Comparison of the model with experimental results reported by others would indicate the accommodative system in cats is highly damped; exhibits both ciliary muscle and lens dynamics and uses both lens deformation and rigid body translation to change the refractive state of the eye.
19 citations
TL;DR: Results indicate that some species increase the percentage of unsaturated fatty acids as an apparent result of cold exposure and some species do not, and a common finding for all cold-sensitive mice was a significant increase in phosphatidic acid.
Abstract: Fatty acids of the individual phospholipids and total neutral lipid fractions in skeletal muscle of three species of Arctic mice were identified and quantitated after the mice had been classified as control, cold-sensitive or cold-resistant. The results indicate that some species increase the percentage of unsaturated fatty acids as an apparent result of cold exposure and some species do not. A common finding for all cold-sensitive mice was a significant increase in 14∶0 in phosphatidic acid when compared to cold-resistant and control animals. Hypotheses are presented in an attempt to explain this finding.
13 citations
12 citations
TL;DR: There were significant differences in the phospholipid composition of red and white muscle, especially in the diphosphatidyl glycerol (DPG) content, red muscle having over 50% more DPG than white muscle.
Abstract: The phospholipid composition of human and guinea pig skeletal muscle was determined. Virtually no autolytic changes occurred in the first half hour post-mortem and after 12 hr only very small changes were detected. There were significant differences in the phospholipid composition of red and white muscle, especially in the diphosphatidyl glycerol (DPG) content,red muscle having over 50% more DPG than white muscle.
10 citations
TL;DR: It was concluded that the more reactive carboxyl groups are situated in the vicinity of only one of the two iron-binding sites of transferrin and that their modification then destabilizes the coordination complex.
7 citations
01 Dec 1970