Rush University Medical Center

About: Rush University Medical Center is a healthcare organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Dementia. The organization has 13915 authors who have published 29027 publications receiving 1379216 citations. The organization is also known as: Rush Presbyterian St. Luke's Medical Center.

A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial

Abstract: ObjectiveTo evaluate the safety and efficacy of E5, a murine, monoclonal antibody directed against endotoxin, in the treatment of patients with Gram-negative sepsis.DesignA multicenter, randomized, double-blind, placebo-controlled trial.SettingFifty-three hospitals across the United States, includin

Recurrent Shoulder Instability: Current Concepts for Evaluation and Management of Glenoid Bone Loss

Abstract: Recurrent instability of the glenohumeral joint is usually associated with a Bankart tear—a soft-tissue injury of the glenoid labrum attachment. However, patients with recurrent shoulder instability often present with osseous injury to the glenoid and humeral head as well. Understanding and appropriately addressing irregularities in the osseous architecture of the glenohumeral joint are critical to the overall success of surgical repair for the treatment of glenohumeral instability1. The integrity of the osseous architecture of the glenoid has recently been highlighted as one of the most important factors related to the success of surgical repair2,3. After the initial traumatic shoulder dislocation, an associated glenoid rim fracture or attritional bone injury may compromise the static restraints of the glenohumeral joint, making further instability more likely. With recurrent instability, there can be further attritional glenoid bone loss. Glenoid bone deficiency with recurrent shoulder instability is an increasingly recognized cause of failed shoulder stabilization surgery. It is critical to evaluate all patients with recurrent shoulder instability for the presence of osseous injuries to the glenoid. Specific findings in the history and the physical examination provide important clues to the presence of glenoid bone loss, and a careful preoperative evaluation to diagnose and quantify anterior glenoid deficiency is crucial for the success of surgical treatment. Appropriate preoperative imaging is essential for detection and quantification of osseous abnormalities in patients with recurrent shoulder instability. The apical oblique view described by Garth et al.4, the West Point view5, and the Didiee view6 are recognized as being the most sensitive radiographs for detecting osseous abnormalities of the glenoid. Magnetic resonance imaging and magnetic resonance arthrography may be used, but they are primarily employed to assess the surrounding soft tissues. If any osseous lesion is discovered on radiographs, …