Institution
Rush University Medical Center
Healthcare•Chicago, Illinois, United States•
About: Rush University Medical Center is a healthcare organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 13915 authors who have published 29027 publications receiving 1379216 citations. The organization is also known as: Rush Presbyterian St. Luke's Medical Center.
Topics: Population, Medicine, Dementia, Transplantation, Health care
Papers published on a yearly basis
Papers
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TL;DR: One of the cases appears to be the first report of IL associated with a low-grade MALT lymphoma, and it is concluded that CD29 is currently regarded as critical for lymphocyte trafficking in general and for transvascular migration in particular, and CD54 is also involved in transv vascular lymphocyte migration, may contribute to its intravascular and disseminated distribution pattern.
264 citations
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TL;DR: The findings do not suggest a linear association of BP with cognitive decline, but they are consistent with a more complex relationship between BP and cognition than previously appreciated.
Abstract: ContextPrevious studies raise the possibility that blood
pressure (BP) in middle age predicts later cognitive decline.ObjectiveTo examine prospectively the relationship of BP with
level of and change in cognitive function in the elderly.DesignLongitudinal, population-based study comprising
subjects enrolled in the East Boston component of the Established
Populations for the Epidemiologic Study of the Elderly (EPESE)
(1982-1983) and the Hypertension Detection and Follow-Up Program (HDFP)
(1973-1974).SettingEast Boston, Mass.ParticipantsOf the 3657 participants in the EPESE
with baseline BP measurements, 2068 also participated in the HDFP.
Subjects were aged 65 to 102 years at baseline in the EPESE and had
mental status and memory assessed at baseline and 3 and 6 years.Main Outcome MeasuresNumbers of errors on the Short Portable
Mental Status Questionnaire and the East Boston Memory Test and rates
of change in these numbers of errors. Subjects had BP measured both at
baseline in the EPESE and 9 years before, as part of the HDFP.ResultsIn analyses adjusted for age, sex, and education, there
was no strong linear association between BP and cognition. The
associations found were fairly small in magnitude, and varied according
to which test was used to measure cognition. There was little evidence
for an effect of BP on change in cognitive function with either test,
or for an effect on level of function on the memory test. In analyses
of level of mental status questionnaire performance, however, elevated
systolic BP (≥160 mm Hg) 9 years before baseline was associated with a
14% (95% confidence interval [CI], 4%-25%) increase in error
rate, relative to the referent (130-139 mm Hg). Baseline systolic BP
had a U-shaped association with the number of errors; error rates were
9% higher compared with the referent group among those with systolic
BP lower than 130 mm Hg (95% CI, 1%-17%) and 7% greater (95% CI,
0%-15%) among those with elevated systolic BP. Diastolic BP 9 years
before baseline also had a U-shaped association with errors on the
mental status questionnaire.ConclusionThe findings do not suggest a linear association of BP
with cognitive decline, but they are consistent with a more complex
relationship between BP and cognition than previously
appreciated.
264 citations
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TL;DR: Restoration of the originalCD133+ and CD133- populations from CD133+ Daoy cells in serum is further evidence that CD133+, which is believed to be enriched for brain tumor stem cells, is functionally distinct fromCD133- cells.
Abstract: Purpose: Primary medulloblastoma and glioblastoma multiforme tumor cells that express the surface marker CD133 are believed to be enriched for brain tumor stem cells because of their unique ability to initiate or reconstitute tumors in immunodeficient mice. This study sought to characterize the radiobiological properties and marker expression changes of CD133+ vs. CD133− cells of an established medulloblastoma cell line. Methods and Materials: Daoy and D283 Med cell lines were stained with fluorescently labeled anti-CD133 antibody and sorted into CD133+ and CD133− populations. The effect of oxygen (2% vs. 20%) on CD133 expression was measured. Both populations were analyzed for marker stability, cell cycle distribution, and radiosensitivity. Results: CD133+ Daoy cells restored nearly native CD133+ and CD133− populations within 18 days, whereas CD133− cells remained overwhelmingly CD133−. Culturing Daoy cells in 2% oxygen rather than the standard 20% oxygen increased their CD133 expression 1.6-fold. CD133+ Daoy cells were radioresistant via the β-parameter of the linear-quadratic model relative to CD133− Daoy cells, although their α-parameters and cell cycle distributions were identical. Conclusions: Restoration of the original CD133+ and CD133− populations from CD133+ Daoy cells in serum is further evidence that CD133+ cells are functionally distinct from CD133− cells. The radioresistance of CD133+ compared with CD133− Daoy cells is consistent with better repair of sublethal damage. Enlargement of the CD133+ sector is a new feature of the hypoxic response.
264 citations
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TL;DR: Vancomycin-resistant enterococci were transferred from contaminated sites in the environment or on patients' intact skin to clean sites via HCW hands or gloves in 10.6% of opportunities.
Abstract: Background:Therolesofthecontaminatedhospitalenvironment and of patient skin carriage in the spread of vancomycin-resistant enterococci (VRE) are uncertain. Transfer of VRE via health care worker (HCW) hands is assumed but unproved. We sought to determine the frequency of VRE transmission from sites in the environment or on patients’ intact skin to clean environmental orskinsitesviacontaminatedhandsofHCWsduringroutine care. Methods:We cultured sites on the intact skin of 22 patients colonized by VRE, as well as sites in the patients’ rooms, before and after routine care by 98 HCWs. Observers recorded sites touched by HCWs. Cultures were obtained from HCW hands and/or gloves before and after care. All isolates underwent pulsed-field gel electrophoresis. We defined a transfer to have occurred when a culture-negative site became positive with a VRE pulsotype after being touched by an HCW who had the same pulsotypeonhisorherhandsorglovesandwhohadpre
264 citations
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TL;DR: The sequencing of 5-FU CRT with gemcitabine as done in this trial is not associated with a statistically significant improvement in OS, despite local recurrence being approximately half of that reported in previous adjuvant trials, distant disease relapse still occurs in ≥70% of patients.
Abstract: The impact of the addition of gemcitabine to 5-fluorouracil (5-FU) chemoradiation (CRT) on 5-year overall survival (OS) in resected pancreatic adenocarcinoma are presented with updated results of a phase III trial. After resection of pancreatic adenocarcinoma, patients were randomized to pre- and post-CRT 5-FU versus pre- and post-CRT gemcitabine. 5-FU was provided continuously at 250 mg/m2/day, and gemcitabine was provided at 1000 mg/m2 weekly. Both were provided over 3 weeks before and 12 weeks after CRT. CRT was provided at 50.4 Gy with continuously provided 5-FU. The primary end point was survival for all patients and for patients with tumor of the pancreatic head. Four hundred fifty-one patients were eligible. Univariate analysis showed no difference in OS. Pancreatic head tumor patients (n = 388) had a median survival and 5-year OS of 20.5 months and 22% with gemcitabine versus 17.1 months and 18% with 5-FU. On multivariate analysis, patients on the gemcitabine arm with pancreatic head tumors experienced a trend toward improved OS (P = 0.08). First site of relapse local recurrence in 28% of patients versus distant relapse in 73%. The sequencing of 5-FU CRT with gemcitabine as done in this trial is not associated with a statistically significant improvement in OS. Despite local recurrence being approximately half of that reported in previous adjuvant trials, distant disease relapse still occurs in ≥70% of patients. These findings serve as the basis for the recently activated EORTC/U.S. Intergroup RTOG 0848 phase III adjuvant trial evaluating the impact of CRT after completion of a full course of gemcitabine.
264 citations
Authors
Showing all 14032 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Luigi Ferrucci | 193 | 1601 | 181199 |
David A. Bennett | 167 | 1142 | 109844 |
Todd R. Golub | 164 | 422 | 201457 |
David Cella | 156 | 1258 | 106402 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
John D. E. Gabrieli | 142 | 480 | 68254 |
David J. Kupfer | 141 | 862 | 102498 |
Clifford B. Saper | 136 | 406 | 72203 |
Pasi A. Jänne | 136 | 685 | 89488 |
Nikhil C. Munshi | 134 | 906 | 67349 |
Martin B. Keller | 131 | 541 | 65069 |
Michael E. Thase | 131 | 923 | 75995 |
Steven R. Simon | 129 | 1090 | 80331 |