Institution
Rush University Medical Center
Healthcare•Chicago, Illinois, United States•
About: Rush University Medical Center is a healthcare organization based out in Chicago, Illinois, United States. It is known for research contribution in the topics: Population & Dementia. The organization has 13915 authors who have published 29027 publications receiving 1379216 citations. The organization is also known as: Rush Presbyterian St. Luke's Medical Center.
Topics: Population, Dementia, Transplantation, Cognitive decline, Health care
Papers published on a yearly basis
Papers
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TL;DR: The development of porous tantalum is in its early stages of evolution and the following represents a review of its biomaterial properties and applications in orthopedic surgery.
550 citations
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TL;DR: A table that reviews many available quality of life measures that have been designed for, or frequently used with, people with cancer is reviewed.
Abstract: While it is recognized that quality of life is ultimately as important as quantity of life, efforts to implement quality of life measurement often fail. Two basic reasons for that failure include: 1) definitional differences, where different investigators attribute different meaning to the term and, as a result, are measuring different endpoints; and 2) insufficient information about available measures, which can lead to improper test selection and unnecessary regeneration of new items. Included in this paper is a table that reviews many available quality of life measures that have been designed for, or frequently used with, people with cancer. Proper selection of measures and supplementary questions is an important first step toward a successful evaluation of quality of life.
548 citations
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University of California, San Francisco1, Pierre-and-Marie-Curie University2, University of Amsterdam3, International AIDS Society4, National Institutes of Health5, Monash University6, Rush University Medical Center7, Case Western Reserve University8, University of North Carolina at Chapel Hill9, Aaron Diamond AIDS Research Center10, Autonomous University of Barcelona11, University of Washington12, University of Pittsburgh13, University of Pennsylvania14, Karolinska Institutet15, McGill University16, University of Paris17, Emory University18, University of Miami19, University of Lausanne20, Université libre de Bruxelles21, Fred Hutchinson Cancer Research Center22, Beckman Research Institute23, Pasteur Institute24
TL;DR: The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure and several priorities for basic, translational and clinical research were identified.
Abstract: Given the limitations of antiretroviral therapy and recent advances in our understanding of HIV persistence during effective treatment, there is a growing recognition that a cure for HIV infection is both needed and feasible. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. Several priorities for basic, translational and clinical research were identified. This Opinion article summarizes the group's recommended key goals for the international community.
543 citations
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University of Pennsylvania1, University of Rochester2, Columbia University3, Medical College of Wisconsin4, University of Southern California5, University of South Florida6, Rutgers University7, Indiana University8, North Shore-LIJ Health System9, Baylor College of Medicine10, Virginia Commonwealth University11, University of Alabama12, Toronto Western Hospital13, Ohio State University14, University of Kansas15, Albany Medical College16, University of Miami17, University of Saskatchewan18, St. Joseph's Hospital and Medical Center19, Creighton University20, University of Minnesota21, Rush University Medical Center22, Yale University23, University of California, San Francisco24, University of Chicago25, Georgia Regents University26, University of Alberta27, Mayo Clinic28, Icahn School of Medicine at Mount Sinai29, Boston University30, University of Toronto31, Oregon Health & Science University32, University of Connecticut33
TL;DR: Rasagiline is effective as monotherapy for patients with early PD and the 2 dosages in this trial were both effective relative to placebo.
Abstract: CONTEXT
Monotherapy with rasagiline mesylate may be useful in early Parkinson disease (PD).
OBJECTIVE
To evaluate the safety and efficacy of the selective monoamine oxidase type B inhibitor rasagiline.
DESIGN
Multicenter, 26-week, parallel-group, randomized, double-blind, placebo-controlled clinical trial.
SETTING
Academically based movement disorders clinics.
PATIENTS
Patients with early PD not requiring dopaminergic therapy (n = 404).
INTERVENTION
Research participants were randomized to rasagiline mesylate at dosages of 1 mg or 2 mg per day or matching placebo. A 1-week escalation period was followed by a 25-week maintenance period.
MAIN OUTCOME MEASURE
The primary prespecified measure of efficacy was the change in the total Unified Parkinson's Disease Rating Scal score between baseline and 26 weeks of treatment, comparing each active treatment group with the placebo group.
RESULTS
Monotherapy with rasagiline was effective in this 26-week study. The adjusted effect size for the total Unified Parkinson's Disease Rating Scale was -4.20 units comparing 1 mg of rasagiline and placebo (95% confidence interval, -5.66 to -2.73 units; P<.001) and -3.56 units comparing a 2-mg dosage and placebo (95% confidence interval, -5.04 to -2.08 units; P<.001). There were no meaningful differences in the frequency of adverse events or premature withdrawals among the treatment groups.
CONCLUSIONS
Rasagiline is effective as monotherapy for patients with early PD. The 2 dosages in this trial were both effective relative to placebo. Further study is warranted to evaluate the longer-term effects of rasagiline in PD.
542 citations
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TL;DR: A higher level of total daily physical activity is associated with a reduced risk of AD, and this model remained after adjusting for self-report physical, social, and cognitive activities.
Abstract: Objective: Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. Methods: Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. Results: During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273–0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007). Conclusions: A higher level of total daily physical activity is associated with a reduced risk of AD.
541 citations
Authors
Showing all 14032 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Luigi Ferrucci | 193 | 1601 | 181199 |
David A. Bennett | 167 | 1142 | 109844 |
Todd R. Golub | 164 | 422 | 201457 |
David Cella | 156 | 1258 | 106402 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
John D. E. Gabrieli | 142 | 480 | 68254 |
David J. Kupfer | 141 | 862 | 102498 |
Clifford B. Saper | 136 | 406 | 72203 |
Pasi A. Jänne | 136 | 685 | 89488 |
Nikhil C. Munshi | 134 | 906 | 67349 |
Martin B. Keller | 131 | 541 | 65069 |
Michael E. Thase | 131 | 923 | 75995 |
Steven R. Simon | 129 | 1090 | 80331 |