Showing papers by "Rutgers University published in 2002"

Mediators and Moderators of Treatment Effects in Randomized Clinical Trials

Abstract: Randomized clinical trials (RCTs) not only are the gold standard for evaluating the efficacy and effectiveness of psychiatric treatments but also can be valuable in revealing moderators and mediators of therapeutic change. Conceptually, moderators identify on whom and under what circumstances treatments have different effects. Mediators identify why and how treatments have effects. We describe an analytic framework to identify and distinguish between moderators and mediators in RCTs when outcomes are measured dimensionally. Rapid progress in identifying the most effective treatments and understanding on whom treatments work and do not work and why treatments work or do not work depends on efforts to identify moderators and mediators of treatment outcome. We recommend that RCTs routinely include and report such analyses.

The Protein Data Bank.

Abstract: The Protein Data Bank [PDB; Berman, Westbrook et al. (2000), Nucleic Acids Res. 28, 235–242; http://www.pdb.org/] is the single worldwide archive of primary structural data of biological macromolecules. Many secondary sources of information are derived from PDB data. It is the starting point for studies in structural bioinformatics. This article describes the goals of the PDB, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource. The reader should come away with an understanding of the scope of the PDB and what is provided by the resource.

American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity

Abstract: The American Cancer Society (ACS) publishes Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and ultimately, to affect dietary and physical activity patterns among Americans. These Guidelines, published every 5 years, are developed by a national panel of experts in cancer research, prevention, epidemiology, public health, and policy, and as such, they represent the most current scientific evidence related to dietary and activity patterns and cancer risk. The ACS Guidelines include recommendations for individual choices regarding diet and physical activity patterns, but those choices occur within a community context that either facilitates or interferes with healthy behaviors. Community efforts are essential to create a social environment that promotes healthy food choices and physical activity. Therefore, this committee presents one key recommendation for community action to accompany the four recommendations for individual choices to reduce cancer risk. This recommendation for community action recognizes that a supportive social environment is indispensable if individuals at all levels of society are to have genuine opportunities to choose healthy behaviors. The ACS Guidelines are consistent with guidelines from the American Heart Association and the American Diabetes Association for the prevention of coronary heart disease and diabetes, as well as for general health promotion, as defined by the Department of Health and Human Services' 2005 Dietary Guidelines for Americans.

Primal leadership : realizing the power of emotional intelligence

Abstract: Preface Acknowledgments Part I The Power of Emotional Intelligence 1. Primal Leadership 2. Resonant Leadership 3. The Neuroanatomy of Leadership 4. The Leadership Repertoire 5. The Dissonant Styles: Apply with Caution Part II Making Leaders 6. Becoming a Resonant Leader: The Five Discoveries 7. The Motivation to Change 8. Metamorphosis: Sustaining Leadership Change Part III Building Emotionally Intelligent Organizations 9. The Emotional Reality of Teams 10. Reality and the Ideal Vision: Giving Life to the Organization's Future 11. Creating Sustainable Change Appendix A EI versus IQ: A Technical Note Appendix B Emotional Intelligence: Leadership Competencies Notes Index About the Authors

Finding Frequent Items in Data Streams

Abstract: We present a 1-pass algorithm for estimating the most frequent items in a data stream using limited storage space. Our method relies on a data structure called a COUNT SKETCH, which allows us to reliably estimate the frequencies of frequent items in the stream. Our algorithm achieves better space bounds than the previously known best algorithms for this problem for several natural distributions on the item frequencies. In addition, our algorithm leads directly to a 2-pass algorithm for the problem of estimating the items with the largest (absolute) change in frequency between two data streams. To our knowledge, this latter problem has not been previously studied in the literature.

Efficient power control via pricing in wireless data networks

Abstract: A major challenge in the operation of wireless communications systems is the efficient use of radio resources. One important component of radio resource management is power control, which has been studied extensively in the context of voice communications. With the increasing demand for wireless data services, it is necessary to establish power control algorithms for information sources other than voice. We present a power control solution for wireless data in the analytical setting of a game theoretic framework. In this context, the quality of service (QoS) a wireless terminal receives is referred to as the utility and distributed power control is a noncooperative power control game where users maximize their utility. The outcome of the game results in a Nash (1951) equilibrium that is inefficient. We introduce pricing of transmit powers in order to obtain Pareto improvement of the noncooperative power control game, i.e., to obtain improvements in user utilities relative to the case with no pricing. Specifically, we consider a pricing function that is a linear function of the transmit power. The simplicity of the pricing function allows a distributed implementation where the price can be broadcast by the base station to all the terminals. We see that pricing is especially helpful in a heavily loaded system.

Perpetual Contact: Mobile Communication, Private Talk, Public Performance

Abstract: From the Publisher: Mobile phones affect every aspect of our personal and professional lives. They have transformed social practices and changed the way we do business, yet surprisingly little serious academic work has been done on them. This book studies the impact of the mobile phone on contemporary society from a social scientific perspective. Providing a comprehensive overview of mobile phones and social interaction, it comprises an introduction covering the key issues, a series of unique national studies and a final section examining specific issues.

Epistemologically Authentic Inquiry in Schools: A Theoretical Framework for Evaluating Inquiry Tasks

Abstract: A main goal of science education is to help students learn to reason scien- tifically. A main way to facilitate learning is to engage students in inquiry activities such as conducting experiments. This article presents a theoretical framework for evaluating inquiry tasks in terms of how similar they are to authentic science. The framework helps identify the respects in which these reasoning tasks are similar to and different from real scientific research. The framework is based on a recent theory of reasoning, models-of-data theory. We argue that inquiry tasks commonly used in schools evoke reasoning processes that are qualitatively different from the processes employed in real scientific inquiry. More- over, school reasoning tasks appear to be based on an epistemology that differs from the epistemology of authentic science. Inquiry tasks developed by researchers have increas- ingly captured features of authentic science, but further improvement is still possible. We conclude with a discussion of the implications of our analysis for research, assessment, and instruction. C

Institutional entrepreneurship in the sponsorship of common technological standards: The case of Sun Microsystems and Java

Abstract: The institutional entrepreneurship implicit in a firm's sponsorship of its technology as a common standard is beset by several challenges. These challenges arise from a standard's property to enabl...

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.

Abstract: The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.

A meta-analysis of team-efficacy, potency, and performance: interdependence and level of analysis as moderators of observed relationships.

Abstract: Meta-analytic techniques were used to examine level of analysis and interdependence as moderators of observed relationships between task-specific team-efficacy, generalized potency, and performance. Sixty-seven empirical studies yielding 256 effect sizes were identified and meta-analyzed. Results demonstrated that relationships are moderated by level of analysis. Effect sizes were stronger at the team level (p = .39) than at the individual level (p = .20). At the team level, both team-efficacy and potency had positive relationships with performance (ps = .41 and .37, respectively). Interdependence significantly moderated the relationship between team-efficacy and performance, but not between potency and performance. The relationship between team-efficacy and performance was stronger when interdependence was high (p = .45) than when it was low (p = .34).

Radial mixing in galactic discs

Abstract: We show that spiral waves in galaxy discs churn the stars and gas in a manner that largely preserves the overall angular momentum distribution and leads to little increase in random motion. Changes in the angular momenta of individual stars are typically as large as ∼50 per cent over the lifetime of the disc. The changes are concentrated around the corotation radius for an individual spiral wave, but since transient waves with a wide range of pattern speeds develop in rapid succession, the entire disc is affected. This behaviour has profound consequences for the metallicity gradients with radius in both stars and gas, since the interstellar medium is also stirred by the same mechanism. We find observational support for stirring, propose a simple model for the distribution of stars over metallicity and age, and discuss other possible consequences.

The role of optimism in social network development, coping, and psychological adjustment during a life transition.

Abstract: The authors investigated the extent to which social support and coping account for the association between greater optimism and better adjustment to stressful life events. College students of both genders completed measures of perceived stress, depression, friendship network size, and perceived social support at the beginning and end of their 1st semester of college. Coping was assessed at the end of the 1st semester. Greater optimism, assessed at the beginning of the 1st semester of college, was prospectively associated with smaller increases in stress and depression and greater increases in perceived social support (but not in friendship network size) over the course of the 1st semester of college. Mediational analyses were consistent with a model in which increases in social support and greater use of positive reinterpretation and growth contributed to the superior adjustment that optimists experienced.

Inhibition of carcinogenesis by tea.

Abstract: Tea has received a great deal of attention because tea polyphenols are strong antioxidants, and tea preparations have inhibitory activity against tumorigenesis. The bioavailability and biotransformation of tea polyphenols, however, are key factors limiting these activities in vivo. The inhibition of tumorigenesis by green or black tea preparations has been demonstrated in animal models on different organ sites such as skin, lung, oral cavity, esophagus, forestomach, stomach, small intestine, colon, pancreas, and mammary gland. Epidemiological studies, however, have not yielded clear conclusions concerning the protective effects of tea consumption against cancer formation in humans. The discrepancy between the results from humans and animal models could be due to 1) the much higher doses of tea used in animals in comparison to human consumption, 2) the differences in causative factors between the cancers in humans and animals, and 3) confounding factors limiting the power of epidemiological studies to detect an effect. It is possible that tea may be only effective against specific types of cancer caused by certain etiological factors. Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. These mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer.

Neurogenesis may relate to some but not all types of hippocampal-dependent learning.

Abstract: The hippocampal formation generates new neurons throughout adulthood. Recent studies indicate that these cells possess the morphology and physiological properties of more established neurons. However, the function of adult generated neurons is still a matter of debate. We previously demonstrated that certain forms of associative learning can enhance the survival of new neurons and a reduction in neurogenesis coincides with impaired learning of the hippocampal-dependent task of trace eyeblink conditioning. Using the toxin methylazoxymethanol acetate (MAM) for proliferating cells, we tested whether reduction of neurogenesis affected learning and performance associated with different hippocampal dependent tasks: spatial navigation learning in a Morris water maze, fear responses to context and an explicit cue after training with a trace fear paradigm. We also examined exploratory behavior in an elevated plus maze. Rats were injected with MAM (7 mg/kg) or saline for 14 days, concurrent with BrdU, to label new neurons on days 10, 12, and 14. After treatment, groups of rats were tested in the various tasks. A significant reduction in new neurons in the adult hippocampus was associated with impaired performance in some tasks, but not with others. Specifically, treatment with the antimitotic agent reduced the amount of fear acquired after exposure to a trace fear conditioning paradigm but did not affect contextual fear conditioning or spatial navigation learning in the Morris water maze. Nor did MAM treatment affect exploration in the elevated plus maze. These results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal-dependent memories. Hippocampus 2002;12:578–584. © 2002 Wiley-Liss, Inc.

Gender violence: transgender experiences with violence and discrimination.

Abstract: There is a pervasive pattern of discrimination and prejudice against transgendered people within society. Both economic discrimination and experiencing violence could be the result of a larger social climate that severely sanctions people for not conforming to society's norms concerning gender; as such, both would be strongly associated with each other. Questionnaires were distributed to people either through events or through volunteers, and made available upon the World Wide Web. A sample of 402 cases was collected over the span of 12 months (April 1996-April 1997). We found that over half the people within this sample experienced some form of harassment or violence within their lifetime, with a quarter experiencing a violent incident. Further investigation found that experiencing economic discrimination because one is transgendered had the strongest association with experiencing a transgender related violent incident. Economic discrimination was related to transgendered people's experience wit...

The BABAR detector

Abstract: BABAR, the detector for the SLAC PEP-II asymmetric e+e- B Factory operating at the upsilon 4S resonance, was designed to allow comprehensive studies of CP-violation in B-meson decays. Charged particle tracks are measured in a multi-layer silicon vertex tracker surrounded by a cylindrical wire drift chamber. Electromagentic showers from electrons and photons are detected in an array of CsI crystals located just inside the solenoidal coil of a superconducting magnet. Muons and neutral hadrons are identified by arrays of resistive plate chambers inserted into gaps in the steel flux return of the magnet. Charged hadrons are identified by dE/dx measurements in the tracking detectors and in a ring-imaging Cherenkov detector surrounding the drift chamber. The trigger, data acquisition and data-monitoring systems, VME- and network-based, are controlled by custom-designed online software. Details of the layout and performance of the detector components and their associated electronics and software are presented.

Constraining Cosmological Parameters Based on Relative Galaxy Ages

Abstract: We propose to use relative galaxy ages as a means of constraining cosmological parameters. By measuring the age difference between two ensembles of passively evolving galaxies at somewhat different redshifts, one could determine the derivative of redshift with respect to cosmic time, dz/dt. At high redshifts, z ~ 1-2, this measurement would constrain the equation of state of the dark energy, while at low redshifts, z 0.2, it would determine the Hubble constant, H0. Furthermore, we show that d2z/dt2 directly tracks the equation of state of the dark energy; thus, measurements of this quantity at low redshifts can be used to constrain it. The selected galaxies need to be passively evolving on a time much longer than their age difference.

Transmission of Escherichia coli O157:H7 from contaminated manure and irrigation water to lettuce plant tissue and its subsequent internalization.

Abstract: The transmission of Escherichia coli O157:H7 from manure-contaminated soil and irrigation water to lettuce plants was demonstrated using laser scanning confocal microscopy, epifluorescence microscopy, and recovery of viable cells from the inner tissues of plants. E. coli O157:H7 migrated to internal locations in plant tissue and was thus protected from the action of sanitizing agents by virtue of its inaccessibility. Experiments demonstrate that E. coli O157:H7 can enter the lettuce plant through the root system and migrate throughout the edible portion of the plant.

Revisiting the relationships among gender, marital status, and mental health.

Abstract: Three decades ago, Gove introduced his sex‐role theory of mental illness, which attributes women’s higher rates of psychological distress to their roles in society. Central to his hypothesis is that marriage is emotionally advantageous for men and disadvantageous for women. This article revisits this topic with data from the National Survey of Families and Households. The analyses indicate that the emotional benefits of marriage apply equally to men and women, but that men and women respond to marital transitions with different types of emotional problems. The implications of these findings for future research on gender and mental health are discussed.

Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and (−)-Epigallocatechin-3-gallate by Humans: Formation of Different Metabolites and Individual Variability

Abstract: Green tea and tea polyphenols have been studied extensively as cancer chemopreventive agents in recent years. The bioavailability and metabolic fate of tea polyphenols in humans, however, are not clearly understood. In this report, the pharmacokinetic parameters of (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), and (-)-epicatechin (EC) were analyzed after administration of a single oral dose of green tea or decaffeinated green tea (20 mg tea solids/kg) or EGCG (2 mg/kg) to eight subjects. The plasma and urine levels of total EGCG, EGC, and EC (free plus conjugated forms) were quantified by HPLC coupled to an electrochemical detector. The plasma concentration time curves of the catechins were fitted in a one-compartment model. The maximum plasma concentrations of EGCG, EGC, and EC in the three repeated experiments with green tea were 77.9 +/- 22.2, 223.4 +/- 35.2, and 124.03 +/- 7.86 ng/ml, respectively, and the corresponding AUC values were 508.2 +/- 227, 945.4 +/- 438.4, and 529.5 +/- 244.4 ng x h x ml(-1), respectively. The time needed to reach the peak concentrations was in the range of 1.3-1.6 h. The elimination half-lives were 3.4 +/- 0.3, 1.7 +/- 0.4, and 2.0 +/- 0.4 h, respectively. Considerable interindividual differences and variations between repeated experiments in the pharmacokinetic parameters were noted. Significant differences in these pharmacokinetic parameters were not observed when EGCG was given in decaffeinated green tea or in pure form. In the plasma, EGCG was mostly present in the free form, whereas EGC and EC were mostly in the conjugated form. Over 90% of the total urinary EGC and EC, almost all in the conjugated forms, were excreted between 0 and 8 h. Substantial amounts of 4'-O-methyl EGC, at levels higher than EGC, were detected in the urine and plasma. The plasma level of 4'-O-methyl EGC peaked at 1.7 +/- 0.5 h with a half life of 4.4 +/- 1.1 h. Two ring-fission metabolites, (-)-5-(3',4',5'-trihydroxyphenyl)-gamma-valerolactone (M4) and (-)-5-(3',4'-dihydroxyphenyl)-valerolactone (M6), appeared in significant amounts after 3 h and peaked at 8-15 h in the urine as well as in the plasma. These results may be useful for designing the dose and dose frequency in intervention studies with tea and for development of biomarkers of tea consumption.

Exotic plant species alter the microbial community structure and function in the soil

Abstract: Exotic plant species are increasingly becoming the focus of research and have been identified as a component of human-induced global change. Successful invaders may alter soil conditions, but the effect of exotic species on soil microbial communities has not been studied. We studied two exotic understory plant species (Japanese barberry [Berberis thunbergii] and Japanese stilt grass [Microstegium vimineum]) in hardwood forests in northern New Jersey, USA. We sampled bulk and rhizosphere soils under the two exotic species, as well as under a co-occurring native species (blueberry [Vaccinium spp.]). We indexed the structure (by measuring phospholipid fatty acid [PLFA] profiles) and function (by measuring enzyme activities and substrate-induced respiration [SIR] profiles) of microbial communities in the sampled soils. Soils under the three species differed in microbial community structure and function. These differences were observed in both the rhizosphere and bulk soil samples. Differences in the structural variables were correlated to differences in the functional variables as demonstrated by canonical correlation analysis. These results indicate that successful exotic invasive species can have profound effects on the microbial community of the soil.

Perceived need and help-seeking in adults with mood, anxiety, or substance use disorders.

Abstract: Background A majority of adults with common mental disorders do not seek professional help. To better understand why not, we examined the correlates of various stages of help-seeking, including perceived need for professional help, seeking such help, and from which professionals participants sought help. Methods The sample for this study comprised 1792 participants in the National Comorbidity Survey, conducted from 1990-1992, who were diagnosed with a 12-month DSM-III-R mood, anxiety, or substance disorder. In this sample, we assessed correlates of perceived need for professional help, seeking professional help among those with a need, and, among those who did seek professional help, seeking help from mental health professionals. Results Mood disorders, comorbid mood and anxiety disorders, and mental disorders associated with impairment in role functioning or suicidality were strong predictors of perceived need. Psychopathology was also associated with the decision to seek help from mental health professionals, but not with the decision to seek professional help overall. After controlling for the nature and severity of psychopathology, various sociodemographic and attitudinal factors appeared to be associated with perception of need, help-seeking, and participants' choices of professionals. Conclusions Unmet need for mental health care is a serious public health problem. Meeting this need requires expanding our attention beyond psychopathology to various evaluations and decisions that affect help-seeking. Our results suggest the importance of attitude and behavior change strategies in reducing the gap between need and care.