Rutgers University

About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.

Wireless device identification with radiometric signatures

Abstract: We design, implement, and evaluate a technique to identify the source network interface card (NIC) of an IEEE 802.11 frame through passive radio-frequency analysis. This technique, called PARADIS, leverages minute imperfections of transmitter hardware that are acquired at manufacture and are present even in otherwise identical NICs. These imperfections are transmitter-specific and manifest themselves as artifacts of the emitted signals. In PARADIS, we measure differentiating artifacts of individual wireless frames in the modulation domain, apply suitable machine-learning classification tools to achieve significantly higher degrees of NIC identification accuracy than prior best known schemes.We experimentally demonstrate effectiveness of PARADIS in differentiating between more than 130 identical 802.11 NICs with accuracy in excess of 99%. Our results also show that the accuracy of PARADIS is resilient against ambient noise and fluctuations of the wireless channel.Although our implementation deals exclusively with IEEE 802.11, the approach itself is general and will work with any digital modulation scheme.

Basement Membranes: Cell Scaffoldings and Signaling Platforms

Abstract: Basement membranes are widely distributed extracellular matrices that coat the basal aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells. These extracellular matrices, first expressed in early embryogenesis, are self-assembled on competent cell surfaces through binding interactions among laminins, type IV collagens, nidogens, and proteoglycans. They form stabilizing extensions of the plasma membrane that provide cell adhesion and that act as solid-phase agonists. Basement membranes play a role in tissue and organ morphogenesis and help maintain function in the adult. Mutations adversely affecting expression of the different structural components are associated with developmental arrest at different stages as well as postnatal diseases of muscle, nerve, brain, eye, skin, vasculature, and kidney.

Optimal Design of Non-Regenerative MIMO Wireless Relays

Abstract: Given a multiple-antenna source and a multiple-antenna destination, a multiple-antenna relay between the source and the destination is desirable under useful circumstances. A non-regenerative multiple-antenna relay, also called non-regenerative MIMO (multi-input multi-output) relay, is designed to optimize the capacity between the source and the destination. Without a direct link between the source and the destination, the optimal canonical coordinates of the relay matrix are first established, and the optimal power allocations along these coordinates are then found. The system capacity with the optimal relay matrix is shown to be significantly higher than those with heuristic relay matrices. When a direct link is present, upper and lower bounds of the optimal system capacity are discussed.

Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units.

Abstract: Importance The recent and ongoing coronavirus disease 2019 (COVID-19) pandemic has taken an unprecedented toll on adults critically ill with COVID-19 infection. While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs). Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes. Design, Setting, and Participants This cross-sectional study included children positive for COVID-19 admitted to 46 North American PICUs between March 14 and April 3, 2020. with follow-up to April 10, 2020. Main Outcomes and Measures Prehospital characteristics, clinical trajectory, and hospital outcomes of children admitted to PICUs with confirmed COVID-19 infection. Results Of the 48 children with COVID-19 admitted to participating PICUs, 25 (52%) were male, and the median (range) age was 13 (4.2-16.6) years. Forty patients (83%) had significant preexisting comorbidities; 35 (73%) presented with respiratory symptoms and 18 (38%) required invasive ventilation. Eleven patients (23%) had failure of 2 or more organ systems. Extracorporeal membrane oxygenation was required for 1 patient (2%). Targeted therapies were used in 28 patients (61%), with hydroxychloroquine being the most commonly used agent either alone (11 patients) or in combination (10 patients). At the completion of the follow-up period, 2 patients (4%) had died and 15 (31%) were still hospitalized, with 3 still requiring ventilatory support and 1 receiving extracorporeal membrane oxygenation. The median (range) PICU and hospital lengths of stay for those who had been discharged were 5 (3-9) days and 7 (4-13) days, respectively. Conclusions and Relevance This early report describes the burden of COVID-19 infection in North American PICUs and confirms that severe illness in children is significant but far less frequent than in adults. Prehospital comorbidities appear to be an important factor in children. These preliminary observations provide an important platform for larger and more extensive studies of children with COVID-19 infection.

Alternative polyadenylation of mRNA precursors.

Abstract: Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation.