Institution
Rutgers University
Education•New Brunswick, New Jersey, United States•
About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.
Topics: Population, Poison control, Health care, Cancer, Galaxy
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that resting state fMRI can be used to investigate human amygdala networks at a greater level of detail than previously appreciated, allowing for the further advancement of translational models.
715 citations
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University of South Florida1, Medical College of Wisconsin2, Fred Hutchinson Cancer Research Center3, Emory University4, University of Florida5, Harvard University6, Washington University in St. Louis7, Dalhousie University8, Dresden University of Technology9, Stanford University10, Oregon Health & Science University11, University of Utah12, University of Pennsylvania13, University of Michigan14, Virginia Commonwealth University15, Mayo Clinic16, University of Texas MD Anderson Cancer Center17, National Institutes of Health18, Rutgers University19, Ottawa Hospital Research Institute20, National Marrow Donor Program21
TL;DR: A phase 3, multicenter, randomized trial of transplantation of peripheral-blood stem cells versus bone marrow from unrelated donors did not detect significant survival differences, and exploratory analyses of secondary end points indicated that peripheral- Blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduceThe risk of chronic GVHD.
Abstract: BACKGROUND Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases the risks of acute and chronic graft-versus-host disease (GVHD), as compared with the transplantation of bone marrow. Some studies have also shown that peripheral-blood stem cells are associated with a decreased rate of relapse and improved survival among recipients with high-risk leukemia. METHODS We conducted a phase 3, multicenter, randomized trial of transplantation of peripheral-blood stem cells versus bone marrow from unrelated donors to compare 2-year survival probabilities with the use of an intention-to-treat analysis. Between March 2004 and September 2009, we enrolled 551 patients at 48 centers. Patients were randomly assigned in a 1:1 ratio to peripheral-blood stem-cell or bone marrow transplantation, stratified according to transplantation center and disease risk. The median follow-up of surviving patients was 36 months (interquartile range, 30 to 37). RESULTS The overall survival rate at 2 years in the peripheral-blood group was 51% (95% confidence interval [CI], 45 to 57), as compared with 46% (95% CI, 40 to 52) in the bone marrow group (P = 0.29), with an absolute difference of 5 percentage points (95% CI, −3 to 14). The overall incidence of graft failure in the peripheral-blood group was 3% (95% CI, 1 to 5), versus 9% (95% CI, 6 to 13) in the bone marrow group (P = 0.002). The incidence of chronic GVHD at 2 years in the peripheral-blood group was 53% (95% CI, 45 to 61), as compared with 41% (95% CI, 34 to 48) in the bone marrow group (P = 0.01). There were no significant between-group differences in the incidence of acute GVHD or relapse. CONCLUSIONS We did not detect significant survival differences between peripheral-blood stem-cell and bone marrow transplantation from unrelated donors. Exploratory analyses of secondary end points indicated that peripheral-blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduce the risk of chronic GVHD. (Funded by the National Heart, Lung, and Blood Institute–National Cancer Institute and others; ClinicalTrials.gov number, NCT00075816.)
715 citations
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TL;DR: The results help to explain why maize is such a variable crop, and suggest that maize domestication required hundreds of years, and confirm previous evidence that maize was domesticated from Balsas teosinte of southwestern Mexico.
Abstract: The domestication of all major crop plants occurred during a brief period in human history about 10,000 years ago1. During this time, ancient agriculturalists selected seed of preferred forms and culled out seed of undesirable types to produce each subsequent generation. Consequently, favoured alleles at genes controlling traits of interest increased in frequency, ultimately reaching fixation. When selection is strong, domestication has the potential to drastically reduce genetic diversity in a crop. To understand the impact of selection during maize domestication, we examined nucleotide polymorphism in teosinte branched1, a gene involved in maize evolution2. Here we show that the effects of selection were limited to the gene's regulatory region and cannot be detected in the protein-coding region. Although selection was apparently strong, high rates of recombination and a prolonged domestication period probably limited its effects. Our results help to explain why maize is such a variable crop. They also suggest that maize domestication required hundreds of years, and confirm previous evidence that maize was domesticated from Balsas teosinte of southwestern Mexico.
714 citations
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TL;DR: In this article, the authors proposed to generate sets of isogenic disease and control human pluripotent stem cells that differ exclusively at either of two susceptibility variants for Parkinson's disease by modifying the underlying point mutations in the α-synuclein gene.
713 citations
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01 Jul 2005-International Journal of Human-computer Studies \/ International Journal of Man-machine Studies
TL;DR: PassPoints is described, a new and more secure graphical password system, and an empirical study comparing the use of PassPoints to alphanumeric passwords is reported, which shows that the graphical password users created a valid password with fewer difficulties than the alphan numeric users.
Abstract: Computer security depends largely on passwords to authenticate human users. However, users have difficulty remembering passwords over time if they choose a secure password, i.e. a password that is long and random. Therefore, they tend to choose short and insecure passwords. Graphical passwords, which consist of clicking on images rather than typing alphanumeric strings, may help to overcome the problem of creating secure and memorable passwords. In this paper we describe PassPoints, a new and more secure graphical password system. We report an empirical study comparing the use of PassPoints to alphanumeric passwords. Participants created and practiced either an alphanumeric or graphical password. The participants subsequently carried out three longitudinal trials to input their password over the course of 6 weeks. The results show that the graphical password users created a valid password with fewer difficulties than the alphanumeric users. However, the graphical users took longer and made more invalid password inputs than the alphanumeric users while practicing their passwords. In the longitudinal trials the two groups performed similarly on memory of their password, but the graphical group took more time to input a password.
713 citations
Authors
Showing all 69437 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Daniel Levy | 212 | 933 | 194778 |
Eugene V. Koonin | 199 | 1063 | 175111 |
Eric Boerwinkle | 183 | 1321 | 170971 |
David L. Kaplan | 177 | 1944 | 146082 |
Derek R. Lovley | 168 | 582 | 95315 |
Mark Gerstein | 168 | 751 | 149578 |
Gang Chen | 167 | 3372 | 149819 |
Hongfang Liu | 166 | 2356 | 156290 |
Robert Stone | 160 | 1756 | 167901 |
Mark E. Cooper | 158 | 1463 | 124887 |
Michael B. Sporn | 157 | 559 | 94605 |
Cumrun Vafa | 157 | 509 | 88515 |
Wolfgang Wagner | 156 | 2342 | 123391 |
David M. Sabatini | 155 | 413 | 135833 |