Rutgers University

About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Abstract: Genome-sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely inactivated. We identify rare and likely deleterious LoF alleles, including 26 known and 21 predicted severe disease-causing variants, as well as common LoF variants in nonessential genes. We describe functional and evolutionary differences between LoF-tolerant and recessive disease genes and a method for using these differences to prioritize candidate genes found in clinical sequencing studies.

Board of Director Diversity and Firm Financial Performance

Abstract: This study examines the relationship between demographic diversity on boards of directors with firm financial performance. This relationship is examined using 1993 and 1998 financial performance data (return on asset and investment) and the percentage of women and minorities on boards of directors for 127 large US companies. Correlation and regression analyses indicate board diversity is positively associated with these financial indicators of firm performance. Implications for both strategic human resource management and future research are discussed.

A Luminescent Microporous Metal–Organic Framework for the Fast and Reversible Detection of High Explosives

Abstract: Ein hoch empfindlicher Sensor: Mit dem intensiv lumineszierenden mikroporosen Metall-organischen Gerust [Zn2(bpdc)2(bpee)] (bpdc=4,4′-Biphenyldicarboxylat; bpee=1,2-Bipyridylethen) lassen sich Dampfe des Nitrosprengstoffs 2,4-Dinitrotoluol und von 2,3-Dimethyl-2,3-dinitrobutan, das Plastiksprengstoff als Markierung zugemischt wird, durch Redox-Fluoreszenzloschung sehr schnell, reversibel und mit unerreichter Empfindlichkeit nachweisen (siehe Spektren).

Elements of large-sample theory

Abstract: This introductory book on the most useful parts of large-sample theory is designed to be accessible to scientists outside statistics and certainly to master’s-level statistics students who ignore most of measure theory. According to the author, “the subject of this book, first-order large- sample theory, constitutes a coherent body of concepts and results that are central to both theoretical and applied statistics.” All of the other existing books published on the subject over the last 20 years, from Ibragimov and Has’minskii in 1979 to the most recent by Van der Waart in 1998 have a common prerequisite in mathematical sophistication (measure theory in particular) that do not make the concepts available to a wide audience.

Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements

Abstract: Simultaneous recording from large numbers of neurons is a prerequisite for understanding their cooperative behavior. Various recording techniques and spike separation methods are being used toward ...