Rutgers University

About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.

Role of the polycomb protein EED in the propagation of repressive histone marks

Abstract: Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells.

Sense of community in the urban environment: A catalyst for participation and community development

Abstract: Social programs need to identify catalysts for action which can be targeted in order to effectively and efficiently meet their goals. A model illustrates how a sense of community can have a catalytic effect on local action (i.e., participation in a block association) by affecting the perception of the environment, social relations, and one’s perceived control and empowerment The model is tested and confirmed through path-analytic and longitudinal techniques.

Network coordination for spectrally efficient communications in cellular systems

Abstract: In this article we consider network coordination as a means to provide spectrally efficient communications in cellular downlink systems. When network coordination is employed, all base antennas act together as a single network antenna array, and each mobile may receive useful signals from nearby base stations. Furthermore, the antenna outputs are chosen in ways to minimize the out-of-cell interference, and hence to increase the downlink system capacity. When the out-of-cell interference is mitigated, the links can operate in the high signal-to-noise ratio regime. This enables the cellular network to enjoy the great spectral efficiency improvement associated with using multiple antennas

Global patterns and predictors of marine biodiversity across taxa

Abstract: Using large-scale data sets, these authors present a new assessment of global marine species diversity and its correlation with environmental and spatial parameters.

Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination

Abstract: One-third of humans are infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. Sequence analysis of two megabases in 26 structural genes or loci in strains recovered globally discovered a striking reduction of silent nucleotide substitutions compared with other human bacterial pathogens. The lack of neutral mutations in structural genes indicates that M. tuberculosis is evolutionarily young and has recently spread globally. Species diversity is largely caused by rapidly evolving insertion sequences, which means that mobile element movement is a fundamental process generating genomic variation in this pathogen. Three genetic groups of M. tuberculosis were identified based on two polymorphisms that occur at high frequency in the genes encoding catalase-peroxidase and the A subunit of gyrase. Group 1 organisms are evolutionarily old and allied with M. bovis, the cause of bovine tuberculosis. A subset of several distinct insertion sequence IS6110 subtypes of this genetic group have IS6110 integrated at the identical chromosomal insertion site, located between dnaA and dnaN in the region containing the origin of replication. Remarkably, study of ≈6,000 isolates from patients in Houston and the New York City area discovered that 47 of 48 relatively large case clusters were caused by genotypic group 1 and 2 but not group 3 organisms. The observation that the newly emergent group 3 organisms are associated with sporadic rather than clustered cases suggests that the pathogen is evolving toward a state of reduced transmissability or virulence.