Showing papers by "Saint Francis University published in 1986"
TL;DR: Indomethacin blocked the stimulatory effect on CDP and NCP labeling, suggesting a prostaglandin-mediated effect, but did not change the IL-1 effect on DNA synthesis, but exposure of the calvariae to highIL-1 doses or to IL- 1 for prolonged periods of time results in an inhibition of collagen synthesis.
Abstract: Interleukin-1 (IL-1), a monokine known to be important in host defense mechanisms and recently reported to stimulate bone resorption, was studied for its effects on bone formation in cultures of 21-day-old fetal rat calvariae. IL-1 at 0.1–5 U/ml stimulated the incorporation of [3H] thymidine into acid-insoluble residues (DNA) by 29–123% in calvariae treated for 24–96 h. IL-1 also increased the bone DNA content and the number of mitoses after colcemid arrest. IL-1 stimulated total protein synthesis. Treatment with IL-1 at 0.01–1 U/ml for 24 h caused a small increase in the incorporation of [3H]proline into collagenase-digestible protein (CDP) and noncollagen protein (NCP). However, higher doses of IL-1 (5 U/ml) or longer exposure to the agent (1 U/ml for 96 h) inhibited the labeling of CDP but not of NCP. IL-1 affected only type I collagen. The stimulatory effects of IL-1 on DNA, CDP, and NCP labeling were independent, since they were observed at different doses, and hydroxyurea abolished the effect on DNA...
176 citations
TL;DR: Poor compliance, as exhibited by fabricated test results and failure to record test results, occurred in a significant proportion of children with type 1 diabetes.
71 citations
TL;DR: A permissive attitude toward participation of patients with mitral valve prolapse in competitive athletics is probably warranted; however, it would appear reasonable to disqualify athletes in the following circumstances: history of syncope; disabling chest pain; complex ventricular arrhythmias, particularly if induced or worsened by exercise.
55 citations
TL;DR: Two cases of gallbladder volvulus in two octogenarian patients are presented from the authors' institution and the etiology of this rare entity is discussed with particular emphasis on visceroptosis, a common finding in elderly patients.
Abstract: Volvulus of the gallbladder is an extremely rare condition presenting often in elderly patients commonly mimicking acute cholecystitis. Two cases of gallbladder volvulus in two octogenarian patients are presented from our institution. Clinical presentation is reviewed and some characteristic clinical and radiographic findings are described. The etiology of this rare entity is discussed with particular emphasis on visceroptosis, a common finding in elderly patients. The importance of early recognition and rapid treatment of this potentially fatal disease is emphasized. It is possible with increasing longevity, with its accompanying tendency to visceroptosis, that this entity may occur more frequently in the future. Its recognition and proper treatment is essential to good results in this elderly group of patients.
38 citations
TL;DR: In this article, the authors examined the use of self-selected music as a conditioning aid during prepared childbirth education and subsequent family performance in labor within a musical environment, and found that the value of music to both the family and the health care staff is felt to be of enough subjective significance to warrant its use as a normal component of prepared birth education.
Abstract: The addition of self-selected music as a conditioning aid during prepared childbirth education and subsequent family performance in labor within a musical environment were examined. Thirty primigravida couples received the same psychoprophylactic instruction, with 15 randomly selected couples receiving the added musical conditioning aid. Medication use remained minimal, without significant difference, for couples who did and couples who did not use music. However, the value of music to both the family and the health care staff is felt to be of enough subjective significance to warrant its use as a normal component of prepared childbirth education.
24 citations
TL;DR: Two commercial sources of MRC-5 and primary rabbit kidney cell cultures were compared for sensitivity of herpes simplex virus isolation and cytopathic effect detection time and no significant difference was found among the 96 positive specimens evaluated.
5 citations
TL;DR: In this article, the authors examined physicians' use of clinical appearance versus historical and laboratory information in medical decision making, 29 pediatric residents were shown videotapes of febrile infants and accompanying clinical histories of varying severity.
Abstract: In order to examine physicians' use of clinical appearance versus historical and laboratory information in medical decision making, 29 pediatric residents were shown videotapes of febrile infants and accompanying clinical histories of varying severity. The results showed that contradictory visual and historical information led to higher, but much more variable, diagnostic likelihood estimates. Severity of appearance was directly related to further diagnostic and therapeutic action but was inversely related to confidence in diagnostic likelihood estimates. Clinical appearance plays an important role in medical decision making but when coupled with contradictory historical information may pose difficulties for physicians attempting to assess diagnostic likelihood.