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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


Papers
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Journal ArticleDOI
TL;DR: Experiments in mice have shown that downregulation or neutralization of Wnt antagonists enhances bone formation, and Phase II clinical trials show that 1-year treatment with antisclerostin antibodies increasesBone formation, decreases bone resorption and leads to a substantial increase in BMD.
Abstract: Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural deterioration of the skeleton, compromised bone strength and an increased risk of fragility fractures. Most current therapies for osteoporosis stabilize the skeleton by inhibiting bone resorption (antiresorptive agents), but the development of anabolic therapies that can increase bone formation and bone mass is of great interest. Wnt signalling induces differentiation of bone-forming cells (osteoblasts) and suppresses the development of bone-resorbing cells (osteoclasts). The Wnt pathway is controlled by antagonists that interact either directly with Wnt proteins or with Wnt co-receptors. The importance of Wnt signalling in bone formation is indicated by skeletal disorders such as sclerosteosis and van Buchem syndrome, which are caused by mutations in the gene encoding the Wnt antagonist sclerostin (SOST). Experiments in mice have shown that downregulation or neutralization of Wnt antagonists enhances bone formation. Phase II clinical trials show that 1-year treatment with antisclerostin antibodies increases bone formation, decreases bone resorption and leads to a substantial increase in BMD. Consequently, Wnt signalling can be targeted by the neutralization of its extracellular antagonists to obtain a skeletal anabolic response.

246 citations

Journal ArticleDOI
13 Mar 1996-JAMA
TL;DR: Women who received thrombolytic therapy for treatment of acute myocardial infarction were at greater risk for both fatal and nonfatal complications than men.
Abstract: Objective. —To compare baseline characteristics, complications, and treatment-specific outcomes of women and men with acute myocardial infarction treated with thrombolytic therapy. Design. —Randomized controlled trial. Patients and Setting. —A total of 10315 women and 30706 men with acute myocardial infarction treated in 1081 hospitals in 15 countries as part of the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I). Intervention. —One of four thrombolytic regimens: (1) streptokinase with subcutaneous heparin; (2) streptokinase with intravenous heparin; (3) streptokinase plus alteplase (tissue-type plasminogen activator) with intravenous heparin; or (4) accelerated alteplase with intravenous heparin. Main Outcome Measures. —Mortality, stroke, and nonfatal complications during 30-day follow-up. Results. —Women were on average 7 years older than men and delayed 18 minutes (median) longer after symptom onset before presenting to the hospital. After adjustment for age, women more often had a history of diabetes, hypertension, and smoking than men. Time to treatment was significantly longer in women (1.2 vs 1.0 hours; P P P P P P P P Conclusion. —Women who received thrombolytic therapy for treatment of acute myocardial infarction were at greater risk for both fatal and nonfatal complications than men. ( JAMA . 1996;275:777-782)

246 citations

Journal ArticleDOI
TL;DR: The treatment protocol used in this study was successful for 89.5% of the patients and patients continued to have significant pain, but did not have operative treatment, and five patients elected to have surgical intervention.
Abstract: One hundred five patients (70% female and 30% male; average age, 48 years) with 132 symptomatic heels were treated according to a standard nonoperative protocol and then reviewed at an average follow-up of 29 months. The treatment protocol consisted of nonsteroidal anti-inflammatory medications, relative rest, viscoelastic polymer heel cushions, Achilles tendon stretching exercises, and, occasionally, injections. Obesity, lifestyle (athletic versus sedentary), sex, and presence or size of heel spur did not influence the treatment outcome. Ninety-four patients (89.5%) had resolution of heel pain within 10.9 months. Six patients (5.7%) continued to have significant pain, but did not elect to have operative treatment, and five patients (4.8%) elected to have surgical intervention. Despite attention to the outcome of surgical treatment for heel pain in the current literature, initial treatment for heel pain is nonoperative. The treatment protocol used in this study was successful for 89.5% of the patients.

242 citations

Journal ArticleDOI
TL;DR: It is indicated that glucocorticoids have a dual effect on type I collagen synthesis and alkaline phosphatase activity in cultured calvariae: a transient stimulatory effect after short term treatment and an inhibitory one after long term exposure.
Abstract: Glucocorticoid-induced osteoporosis is believed to be caused by increased bone resorption and decreased bone formation. However, the direct effects of glucocorticoids on bone formation are, as yet, not fully understood. Cortisol, corticosterone, and dexamethasone were examined for their effects on alkaline phosphatase activity, the incorporation of [3H]proline into type I collagen, DNA content, and mitotic index in intact 21-day-old fetal rat calvariae. After 24 h of treatment, cortisol at 1-100 nM increased the incorporation of [3H]proline into type I collagen, whereas at 1-10 microM, cortisol inhibited type I collagen labeling. After 96 h, cortisol (0.1-10 microM) had an inhibitory effect on type I collagen labeling and alkaline phosphatase activity. Cortisol had a small, not dose dependent, and transient stimulatory effect on alkaline phosphatase which appeared after 12-24 h of exposure, whereas the inhibitory effect was dose related, it appeared and was near-maximal after 48 h of continuous treatment with cortisol. Corticosterone and dexamethasone had an effect similar to that of cortisol on type I collagen synthesis and alkaline phosphatase activity. None of the steroids tested affected the release of the enzyme into the culture medium. Cortisol, corticosterone, and dexamethasone did not alter calvarial DNA content after 24 h of treatment, but after 96, concentrations of 1 nM to 10 microM were inhibitory. The decrease in DNA appeared after 48 h of exposure to 100 nM cortisol and was maximal after 72 h. Histological sections showed a marked and generalized decrease in the number of mitoses after colcemid arrest in calvariae treated with 100 nM cortisol, corticosterone, or dexamethasone for 96 h. These studies indicate that glucocorticoids have a dual effect on type I collagen synthesis and alkaline phosphatase activity in cultured calvariae: a transient stimulatory effect after short term treatment and an inhibitory one after long term exposure. The latter is related to a generalized decrease in cell population.

240 citations


Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897