Institution
Saint Francis University
Education•Loretto, Pennsylvania, United States•
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.
Topics: Population, Osteoblast, Growth factor, Bone cell, Bone remodeling
Papers published on a yearly basis
Papers
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TL;DR: A proposed schema identifies the theoretical elements associated with pressure ulcer development in infants and focuses on the unique attributes of full‐term and preterm newborns that have an impact on pressure ulcers development.
Abstract: The science of pressure ulcer development in infants is underdeveloped. Although recent conceptual frameworks have been applied to younger populations, this article focuses on the unique attributes of full-term and preterm newborns that have an impact on pressure ulcer development. A proposed schema identifies the theoretical elements associated with pressure ulcer development in infants.
26 citations
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TL;DR: With the advent of phacoemulsification, much interest has again been rekindled in extracapsular cataract surgery and its effects on the vitreoretinopathy associated in high myopia.
26 citations
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TL;DR: PEGPH20 degrades hyaluronan (HA), a major component of the stroma, increases delivery of gemcitabine and prolongs survival in preclinical models and evaluates the activity of PEG PH20 in patients with central giant cell granuloma.
Abstract: 208Background: PEGPH20 degrades hyaluronan (HA), a major component of the stroma, increases delivery of gemcitabine and prolongs survival in preclinical models. We evaluated the activity of PEGPH20...
26 citations
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TL;DR: Nanowires have a large aspect ratio and large available surface area, which have made them a potential platform for applications in biosensors as well as electronic/optic and power storage de...
Abstract: Nanowires (NWs) have a large aspect ratio and large available surface area, which have made them a potential platform for applications in biosensors as well as electronic/optic and power storage de...
26 citations
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TL;DR: The actions of alendronate in Ob's suggest potential additional effects in bone remodeling, and bisphosphonate at concentrations higher than 10 μM markedly stimulated the synthesis of collagenase messenger RNA (mRNA) and immunoreactive protein in Ob.
Abstract: Bisphosphonates inhibit bone resorption by reducing osteoclastic cell number and activity. Alendronate is a nitrogen-containing bisphosphonate analog used in the treatment of postmenopausal osteoporosis. The effects of alendronate in osteoclasts are well documented; however, there is limited information on the actions of alendronate in osteoblasts (Ob's). In this study, we investigated the effects of alendronate at concentrations of 1-100 μM on the synthesis of collagenase 3 or matrix metalloproteinase 13 (MMP-13) and tissue inhibitors of MMPs (TIMPs) 1, 2, and 3 in primary Ob-enriched cells from 22-day-old fetal rat calvariae. Alendronate at concentrations higher than 10 μM markedly stimulated the synthesis of collagenase messenger RNA (mRNA) and immunoreactive protein in Ob's. Alendronate did not stimulate the transcriptional rate of the collagenase 3 gene. However, in transcriptionally arrested cells, alendronate prolonged the half-life of collagenase transcripts. Alendronate did not alter the expression of TIMP 1 and 2, but modestly stimulated the expression of TIMP 3. The actions of alendronate in Ob's suggest potential additional effects in bone remodeling.
26 citations
Authors
Showing all 1697 results
Name | H-index | Papers | Citations |
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Steven M. Greenberg | 105 | 488 | 44587 |
Linus Pauling | 100 | 536 | 63412 |
Ernesto Canalis | 98 | 331 | 30085 |
John S. Gottdiener | 94 | 316 | 49248 |
Dalane W. Kitzman | 93 | 474 | 36501 |
Joseph F. Polak | 91 | 406 | 38083 |
Charles A. Boucher | 90 | 549 | 31769 |
Lawrence G. Raisz | 82 | 315 | 26147 |
Julius M. Gardin | 76 | 253 | 38063 |
Jeffrey S. Hyams | 72 | 357 | 22166 |
James J. Vredenburgh | 65 | 280 | 18037 |
Michael Centrella | 62 | 120 | 11936 |
Nathaniel Reichek | 62 | 248 | 22847 |
Gerard P. Aurigemma | 59 | 212 | 17127 |
Thomas L. McCarthy | 57 | 107 | 10167 |