Saint Francis University

About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.

Neighborhood social control and perceptions of crime and disorder in contemporary urban china

Abstract: By drawing on the two streams of Western literature on “neighborhood effects” and perceptions of neighborhood disorder adapted to the distinctive organizational infrastructure of neighborhoods in contemporary urban China, we examine the contextual effects of different forms of neighborhood social control (i.e., collective efficacy, semipublic control, public control, and market-based control) on different types of perceived disorder (i.e., criminal activity, social disorder, physical disorder, and total disorder) across neighborhoods. The analyses are based on data collected in the year 2013 from a survey of approximately 2,500 households in 50 neighborhoods across the city of Tianjin. Collective efficacy as a form of informal control has a significant effect only for perceived social disorder. Public control as measured by the activities of neighborhood police stations has a significant contextual effect on all forms of perceived disorder, whereas the role of market-based control as represented by contracted community services is limited to perceived physical disorder. Finally, semipublic control as measured by the activities of neighborhood committees significantly affects all forms of perceived disorder, but the direction of the effect is positive. We interpret this positive effect with reference to the complex processes surrounding the “translation” of neighborhood disorderly conditions into perceptions of disorder.

Myelosuppression in patients benefiting from imatinib with hydroxyurea for recurrent malignant gliomas.

Abstract: Reports suggest reasonable efficacy and minimal myelosuppression from combination imatinib and hydroxyurea for recurrent malignant glioma. We retrospectively reviewed 16 patients treated with this regimen who were evaluable for toxicity; 14 were also evaluable for response. The incidence of grade 3–4 hematologic toxicity was 25%. The best radiographic response, by Macdonald criteria, was partial response (PR) in three patients (21%), stable disease (SD) in four (29%), and progressive disease (PD) in seven (50%). One patient with a PR developed therapy-limiting hematologic toxicity on day 19 of treatment, progressing to grade 4 on day 64, and persisting until death on day 127 despite discontinuing both drugs. Another patient with PR and two of four patients with SD also developed grade 3 hematologic toxicity. All patients with grade 3–4 hematologic toxicity had disease control (PR or SD) as best radiographic response, whereas none with PD suffered grade 3–4 hematologic toxicity. Combining imatinib with hydroxyurea is effective in some patients with malignant glioma. However, myelosuppression can persist for months after discontinuing the regimen, precluding further chemotherapy. Disease control may also correlate with hematologic toxicity (p = 0.08), suggesting that glioma and marrow stem cells may share a common sensitivity to this chemotherapy regimen.

Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis

Abstract: Background: The pro-atherosclerotic nature of vitamin D deficiency has been shown to increase cardiovascular events. We further emphasized and evaluated the severity of coronary artery disease (CAD) with varying levels of vitamin D in relation to age, gender, ethnicity and baseline confounders.Methods: A retrospective, single-center study of 9,399 patients admitted between 2005 and 2014 for chest pain who underwent coronary angiography. Patients without a vitamin D level, measured as 25-dihydroxyvitamin D (25[OH]D) were excluded from our study. 25(OH)D deficiency and insufficiency were defined by having serum concentration levels of less than 20 ng/ml and 20 to 29.9 ng/ml, respectively, while normal levels were defined as greater than or equal to 30 ng/ml. We assessed levels of 25(OH)D and extent of coronary disease with coronary angiography as obstructive CAD (left main stenosis of ≥50% or any stenosis of ≥70%), non-obstructive CAD (≥1 stenosis ≥20% but no stenosis ≥70%) and normal coronaries (no...