Institution
Saint Francis University
Education•Loretto, Pennsylvania, United States•
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.
Topics: Population, Osteoblast, Growth factor, Bone cell, Bone remodeling
Papers published on a yearly basis
Papers
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TL;DR: Rapaport et al. as discussed by the authors showed that IV ATP can elevate the depleted ATP pools of advanced cancer patients up to levels found in CF patients with subsequent clinical, biochemical, and quality of life (QOL) improvements.
Abstract: Systemic pools of ATP are elevated in individuals homozygous for cystic fibrosis (CF) as evidenced by elevated blood and plasma ATP levels. This elevated ATP level seems to provide benefit in the presence of advanced solid tumors (Abraham et al., Nature Medicine 2(5):593-596, 1996). We published in this journal a paper showing that IV ATP can elevate the depleted ATP pools of advanced cancer patients up to levels found in CF patients with subsequent clinical, biochemical, and quality of life (QOL) improvements (Rapaport et al., Purinergic Signalling 11(2): 251-262, 2015). We hypothesize that the elevated ATP levels seen in CF patients may be benefiting CF patients in another way: by improving their survival after contracting COVID-19. We discuss here the reasoning behind this hypothesis and suggest how these findings might be applied clinically in the general population.
11 citations
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TL;DR: This report suggests that PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) nanoemulsions represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications.
11 citations
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TL;DR: An alternative method for the treatment of an entrapped stone basket was described, when efforts to remove an engaged stone through the intramural ureter met with marked resistance, using Extracorporeal shock wave lithotripsy to pulverize the stone.
11 citations
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TL;DR: To monitor gadolinium pharmacokinetics in the hearts of patients with chronic myocardial infarcts and to determine the variability of contrast agent concentrations and accuracy of infarCT detection over an hour time period.
Abstract: Purpose
To monitor gadolinium pharmacokinetics in the hearts of patients with chronic myocardial infarcts and to determine the variability of contrast agent concentrations and accuracy of infarct detection over an hour time period.
Materials and Methods
Twenty-five patients with chronic myocardial infarcts were examined. T1 measurements were performed every 2 minutes using an inversion recovery CINE balanced steady-state free precession technique. Paired differences in T1 values over time for the discrimination between the left ventricular (LV) bloodpool, viable, and infarct myocardium were statistically evaluated. The average change per 1, 5, and 10 minutes of the inversion time parameter for optimal nulling of viable myocardium was calculated. Receiver operator characteristic (ROC) curve analysis was performed to compare the performance of late gadolinium-enhanced infarct imaging at increasing delays after contrast agent administration.
Results
Significantly different T1 values were reached after 10 minutes between the LV bloodpool, infarcted, and viable myocardium. The T1 difference between myocardial infarcts and the LV bloodpool increased over time, while the difference between viable myocardium and the LV bloodpool decreased. ROC curve analysis showed a decrease in performance of a fixed T1 value to discriminate between the LV bloodpool and viable myocardium over time, while there was a marked increase in the discrimination between the LV bloodpool and infarcted myocardium.
Conclusion
The ability to discriminate between infarcted myocardium and the LV bloodpool improves with an increasing delay after contrast agent administration while discrimination between viable myocardium and the LV bloodpool decreases. J. Magn. Reson. Imaging 2009;30:763–770. © 2009 Wiley-Liss, Inc.
11 citations
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TL;DR: The latest available evidence in the field is reviewed to highlight the various potential benefits of intravascular imaging, which improves the diagnostic accuracy while optimizing the results of an intervention.
Abstract: Background Intracoronary imaging is an important tool for guiding decision making in the cardiac catheterization laboratory. Sources of data We have reviewed the latest available evidence in the field to highlight the various potential benefits of intravascular imaging. Areas of agreement Coronary angiography has been considered the gold standard test to appropriately diagnose and manage patients with coronary artery disease, but it has the inherent limitation of being a 2-dimensional x-ray lumenogram of a complex 3-dimensional vascular structure. Areas of controversy There is well-established inter- and intra-observer variability in reporting coronary angiograms leading to potential variability in various management strategies. Intracoronary imaging improves the diagnostic accuracy while optimizing the results of an intervention. Utilization of intracoronary imaging modalities in routine practice however remains low worldwide. Increased costs, resources, time and expertise have been cited as explanations for low incorporation of these techniques. Growing points Intracoronary imaging supplements and enhances an operator's decision-making ability based on detailed and objective lesion assessment rather than a subjective visual estimation. The benefits of intravascular imaging are becoming more profound as the complexity of cases suitable for revascularization increases. Areas timely for developing research While the clinical benefits of intravascular ultrasound have been well validated, optical coherence tomography in comparison is a newer technology, with robust clinical trials assessing its clinical benefit are underway.
11 citations
Authors
Showing all 1697 results
Name | H-index | Papers | Citations |
---|---|---|---|
Steven M. Greenberg | 105 | 488 | 44587 |
Linus Pauling | 100 | 536 | 63412 |
Ernesto Canalis | 98 | 331 | 30085 |
John S. Gottdiener | 94 | 316 | 49248 |
Dalane W. Kitzman | 93 | 474 | 36501 |
Joseph F. Polak | 91 | 406 | 38083 |
Charles A. Boucher | 90 | 549 | 31769 |
Lawrence G. Raisz | 82 | 315 | 26147 |
Julius M. Gardin | 76 | 253 | 38063 |
Jeffrey S. Hyams | 72 | 357 | 22166 |
James J. Vredenburgh | 65 | 280 | 18037 |
Michael Centrella | 62 | 120 | 11936 |
Nathaniel Reichek | 62 | 248 | 22847 |
Gerard P. Aurigemma | 59 | 212 | 17127 |
Thomas L. McCarthy | 57 | 107 | 10167 |