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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


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Journal ArticleDOI
TL;DR: It is confirmed by demonstrating that downregulation of Nov destabilizes gremlin transcripts, and this effect is possibly mediated by AU‐rich elements present in the 3′‐UTR of gremlin.
Abstract: Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis in part because it binds bone morphogenetic protein (BMP)-2. In the present study, we investigated whether Nov regulated the expression of the BMP antagonist gremlin. Overexpression of Nov increased gremlin mRNA levels in ST-2 cells, and its downregulation by RNA interference decreased gremlin mRNA. Nov did not affect Grem1 transcription, but prolonged the half-life of gremlin mRNA in ST-2 cells, demonstrating that Nov acts by post-transcriptional mechanisms. This was confirmed by demonstrating that downregulation of Nov destabilizes gremlin transcripts. To assess whether the 3′-untranslated region (UTR) of gremlin mRNA mediated the effect of Nov, the decay of a chimeric cfos gremlin 3′-UTR construct was compared to that of cfos in ST-2 cells. The presence of the gremlin 3′-UTR prolonged the half-life of cfos and was responsible for the effect of Nov. To examine the binding of the gremlin 3′-UTR to ribonucleoproteins, radiolabeled gremlin RNA fragments were incubated with cytosolic extracts from Nov overexpressing and control cells. RNA electrophoretic mobility analysis revealed that Nov enhanced the binding of cytosolic proteins to the fragments spanning the 3′-UTR of gremlin between bases 1,358–1,557 and 1,158–1,357 from the transcriptional start. Mutations of AU-rich elements in these two RNA fragments prevented the formation of RNA–protein complexes induced by Nov. Nov did not alter the binding of cytosolic extracts to sequences present in the 5′-UTR or coding region of gremlin. In conclusion, Nov stabilizes gremlin transcripts, and this effect is possibly mediated by AU-rich elements present in the 3′-UTR of gremlin. J. Cell. Biochem. 112: 715–722, 2011. © 2010 Wiley-Liss, Inc.

5 citations

Journal ArticleDOI
01 Nov 2011-Chest
TL;DR: A 20-year-old man was seen in the ED for an abnormal chest CT scan after he developed pleuritic chest pain in the left upper hemithorax, and the remainder of the review of systems was unremarkable except for Raynaud phenomenon.

5 citations

Journal ArticleDOI
TL;DR: Warren Bennis suggests that this approach to lead gently rather than manage with a firm hand may provide a valuable key to successfully managing in a world of constant change.

5 citations

Journal ArticleDOI
TL;DR: In this paper, the authors encourage physical educators to practice yoga in order to gain balance, strength and flexibility and to release stress and escape the daily pressures that teachers experience, and they also suggest that physical educators should implement yoga in their programs to educate students in both the physical (strength, flexibility) and affective (stress relief).
Abstract: StrategieS 17 Mental health is defined as: “A state of successful performance of mental function, resulting in productive activities, fulfilling relationships with other people, and the ability to adapt to change and cope with adversity” (U.S. Department of Health and Human Services, 1999). Research has shown that engaging in different forms of physical activity is positively correlated with mental health and psychological well-being, but negatively correlated with anxiety, depression and stress (Scully, Kramer, Meade, Graham & Dudgeon, 1999). Literature on stress in the work place is plentiful, as is research that specifically investigates teachers’ stress (Montgomery & Rupp, 2005). Stress may be defined as a state of psychological pressure influenced by three main sources: (a) personality mediators (e.g., constructs of time pressure), (b) environmental factors (e.g., constructs of vocational satisfaction), and (c) emotional responses (e.g., anxiety, depression) (Derogatis, 1987). Physical educators are in the business of selling preventative medicine and wellness, but they are not immune to feeling pressure or stress themselves. Due to the role that physical educators play in the school community, (e.g., coaching throughout the school year, organizing and implementing intramurals, developing walking/running clubs, or coaching youth sports in our communities), it can be difficult for many to find time for their own physical activity, which ultimately compromises their health and well-being. Thus, educators should look for coping strategies that aid in dealing with life’s daily stressors, one of which is yoga. The purpose of this article is two-fold. First, the authors encourage physical educators to practice yoga in order to gain balance, strength and flexibility and to release stress and escape the daily pressures that teachers experience. Second, the authors encourage physical educators to implement yoga in their programs to educate students in both the physical (strength, flexibility) and affective (stress relief) domains. The authors believe that the implementation of yoga in a school community could be very helpful; however, yoga should only complement current quality physical education programs and not replace them. In other words, yoga is not the answer to improving fitness and healthy living in our youth; it is however, a tool that can enhance the well-being of teachers and students alike.

5 citations

Journal ArticleDOI
TL;DR: In this paper, the authors evaluate trends in agricultural mortality before and after the implementation of safety initiatives in the US agriculture industry and present a retrospective review of Kansas mortality data from agriculture-rela...
Abstract: The purpose of this study was to evaluate trends in agricultural mortality before and after implementation of safety initiatives. Retrospective review of Kansas mortality data from agriculture-rela...

5 citations


Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897