Saint Francis University

About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.

The coArtHA trial—identifying the most effective treatment strategies to control arterial hypertension in sub-Saharan Africa: study protocol for a randomized controlled trial

Abstract: Arterial hypertension is the most prevalent risk factor for cardiovascular disease in sub-Saharan Africa. Only a few and mostly small randomized trials have studied antihypertensive treatments in people of African descent living in sub-Saharan Africa. In this open-label, three-arm, parallel randomized controlled trial conducted at two rural hospitals in Lesotho and Tanzania, we compare the efficacy and cost-effectiveness of three antihypertensive treatment strategies among participants aged ≥ 18 years. The study includes patients with untreated uncomplicated arterial hypertension diagnosed by a standardized office blood pressure ≥ 140/90 mmHg. The trial encompasses a superiority comparison between a triple low-dose antihypertensive drug combination versus the current standard of care (monotherapy followed by dual treatment), as well as a non-inferiority comparison for a dual drug combination versus standard of care with optional dose titration after 4 and 8 weeks for participants not reaching the target blood pressure. The sample size is 1268 participants with parallel allocation and a randomization ratio of 2:1:2 for the dual, triple and control arms, respectively. The primary endpoint is the proportion of participants reaching a target blood pressure at 12 weeks of ≤ 130/80 mmHg and ≤ 140/90 mmHg among those aged < 65 years and ≥ 65 years, respectively. Clinical manifestations of end-organ damage and cost-effectiveness at 6 months are secondary endpoints. This trial will help to identify the most effective and cost-effective treatment strategies for uncomplicated arterial hypertension among people of African descent living in rural sub-Saharan Africa and inform future clinical guidelines on antihypertensive management in the region. Clinicaltrials.gov NCT04129840 . Registered on 17 October 2019 ( https://www.clinicaltrials.gov/ ).

The Effect of Different Combinations of Three Stacked Half-Hitches and Suture Materials on an Arthroscopic Knot in a Dry or Wet Environment.

Abstract: Purpose Evidence is lacking on the effect of different combinations of three stacked half-hitches and suture materials on the loop/ knot security of an arthroscopic knot under cyclic loading conditions. The specific aim of this study was to identify variables, such as stacked half-hitch configurations, suture materials, and testing environments, that affect knot strength and loop security under cyclic loading conditions. Methods Two suture materials (Orthocord and ForceFiber) were used to tie five differently stacked reversing half-hitches on alternating posts (RHAP) in an arthroscopic knot condition. All knots were evaluated in both dry and wet cyclic loading tests. Results Knots tied with three identical half-hitches stacked on the same post (Conf #1) resulted in 100% knot slippage regardless of suture material in dry environment. In the wet environment this knot configuration performed slightly better (ForceFiber: 20% survived; Orthocord: 40% survived). With knots tied with one of the half-hitches in the RHAPs reversed, a significant improvement occurred in knot holding compared to Conf #1 (p<0.05). Knots tied with the last half-hitches in the RHAPs reversed using ForceFiber were 100% secure in both test environments; whereas those tied with Orthocord had 70% and 80% security rates in the respective environments. Knots tied with two half-hitches of the RHAPs reversed demonstrated the best overall performance. Conclusion Significant effects for both stacked half-hitch configurations and suture materials on the knot loop and knot security were observed. Caution should be used when tying the 3 RHAPs in a knot using standard arthroscopic techniques. This study may provide a solution that might improve the maximum failure loads observed between orthopaedic surgeons, and achieve better clinical outcomes. Clinical Relevance The findings of this study indicate the importance of three reversing half-hitches on alternating posts in performing arthroscopic knot tying, and provide evidence regarding discrepancies of maximum clinical failure loads observed between orthopaedic surgeons leading to better surgical outcomes.

Identity theft: when bad things happen to your patients' and employees' good name.

Abstract: What should healthcare facility security directors and administrators do when patients or employees are the victims of identity theft? Taking the right steps to safeguard personal data won't insulate your facility from ever having to deal with this growing crime but, says the author, it will reduce the opportunity and desire for a criminal to steal the data.