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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


Papers
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Book ChapterDOI
01 Jan 2022
TL;DR: In this article, the basic concepts of pressure maintenance and active mechanisms during pressure maintenance in naturally fractured reservoirs are summarized and the essential concepts in simulation of pressure management in fractured reservoirs is provided.
Abstract: Gas injection into the gas cap which is known as pressure maintenance or crestal gas injection is done to increase the reservoir pressure. Different types of gas may be injected in this method including producing gas, N2, CO2 etc. The injected gas is chosen base on the field development studies. Each of these gases has some advantage and disadvantages. Gas injection in naturally fractured reservoirs is a challenge which needs more investigation on this subject. This chapter summarizes the basic concepts of pressure maintenance and active mechanisms during pressure maintenance in naturally fractured reservoirs. Also, this chapter provides the essential concepts in simulation of pressure maintenance in fractured reservoirs.

1 citations

Journal ArticleDOI
TL;DR: Intravenous loop diuretics are the most commonly used medication for hospitalized congestive heart failure patients; however, many questions remain regarding their best use.

1 citations

Journal ArticleDOI
TL;DR: VB-111 was safe and well-tolerated alone and in combination with BEV in rGBM patients and was superior to the historical control BELOB BEV arm, 16 versus 8 months (p = 0.003).
Abstract: BACKGROUND: VB-111 is an anti-angiogenic agent consisting of a non-replicating adenovirus vector (Ad-5) with a modified murine pre-proendothelin promoter leading to apoptosis of tumor-vasculature by expressing a fas-chimera transgene in angiogenic-endothelial cells. Safety and efficacy of VB-111 alone and in combination with bevacizumab (BEV) were evaluated in recurrent-Glioblastoma (rGBM) patients in this Phase 1-2 dose-escalation study. METHODS: VB-111 was administered at 3x1012 or 1x1013 bimonthly until progression, followed by BEV standard-of-care (SOC). The protocol was amended to add-on BEV 10mg/Kg biweekly combined with VB-111 bimonthly, until further progression. Assessments included safety, pharmacokinetics, overall survival (OS) (Kaplan Meyer) and tumor response (RANO). RESULTS: 46 patients at 4 sites (US and Israel) received up to 13 doses of VB-111. Upon further progression, 24 received VB-111 with BEV, 22 were treated with BEV SOC. VB-111 was safe and well-tolerated alone and in combination with BEV. There were 30 grade ≥3 AEs, of which 6 were considered possibly related to VB-111: thrombocytopenia, pyrexia, brain edema, depressed consciousness, general weakness, pulmonary embolism. Median OS was 16 months for patients receiving combination therapy versus 8 months for those receiving SOC (p= 0.05). OS of combination therapy was superior to the historical control BELOB BEV arm, 16 versus 8 months (p = 0.003). Of 46 patients who received VB-111, 25 patients spiked a fever post-VB-111 dosing at least once, while 21 didn't. Feverish patients demonstrated a median OS of 16 months, compared to non-feverish patients, with a median OS of 8.5 months (p = 0.03). CONCLUSIONS: VB-111 was safe and well-tolerated alone and in combination with BEV in rGBM patients. OS of patients who received VB-111 followed by combination therapy almost doubled compared to historical BEV data, and compared to patients who received VB-111 monotherapy. Toxicities were as expected in this population. A phase 3 randomized controlled trial is currently underway.

1 citations

Journal ArticleDOI

1 citations


Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897