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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


Papers
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Journal ArticleDOI
TL;DR: In this article, Cox regression analysis was used to evaluate the association of altered repolarization with the risk of incident coronary heart disease (CHD) events in older men and women free from clinically overt CHD.
Abstract: T-axis shift has been reported to be an indicator of increased mortality risk We evaluated the association of spatial T-axis deviation with incident coronary heart disease (CHD) events in older men and women free from clinically overt CHD Spatial T-axis deviation was measured from the standard 12-lead electrocardiogram of a subgroup of 4,173 subjects considered free of CHD at baseline in the Cardiovascular Health Study, a prospective cohort study of risk factors for CHD and stroke in older men and women Cox regression analysis was used to evaluate the association of altered repolarization with the risk of incident CHD events The prevalence of marked T-axis deviation (≥45°) was 12% During the median follow-up of 74 years, there were 161 CHD deaths, 743 deaths from all causes, and 679 incident CHD events Adjusting for demographic and clinical risk factors, including other electrocardiographic abnormalities, there was a nearly twofold excess risk of CHD death, and approximately a 50% excess risk of incident CHD and all-cause mortality for those with marked T-axis deviation From other electrocardiographic abnormalities, only QT prolongation was associated with excess risk for incident CHD comparable to that for abnormal T-axis deviation These results suggest that T-axis deviation is an easily quantified marker for subclinical disease and an independent indicator for the risk of incident CHD events in older men and women free of CHD

94 citations

Journal ArticleDOI
TL;DR: Oncoplastic Lumpectomy is a safe alternative to standard lumpectomy for selected breast cancer patients and cosmetic satisfaction is similar between the groups.
Abstract: Background There is a lack of information regarding the safety, complication rate, and cosmetic outcome of oncoplastic breast conserving surgery. The purpose of this study is to evaluate and compare oncoplastic and nononcoplastic procedures. Methods A retrospective review was conducted of patients treated with oncoplastic or nononcoplastic lumpectomies. Immediate and long-term complication rates and cosmetic satisfaction were compared. Results Of the 142 surgeries, 58 were oncoplastic lumpectomies (40.8%). Oncoplastic patients were younger than nononcoplastic patients (60.9 vs 65.2 years, P = .043). Immediate complications were similar with the exception of nonhealing wounds (oncoplastic = 8.6% vs nononcoplastic=1.2%, P = .042). Cosmetic complaints were similar, but fat necrosis was more common in the oncoplastic group (25.9% vs 9.5%, P = .009). Time to radiation and number of future biopsies were similar between the groups. Conclusion Oncoplastic lumpectomy is a safe alternative to standard lumpectomy for selected breast cancer patients.

93 citations

Journal ArticleDOI
TL;DR: It is possible that abnormalities in skeletal IGF I synthesis or activity play a role in the pathogenesis of bone disorders, and it is tempting to postulate the use of IGF I for the treatment of disorders characterized by decreased bone mass.
Abstract: Insulin-like growth factor (IGF) I, a polypeptide synthesized by skeletal cells, is presumed to act as an autocrine regulator of bone formation IGF I stimulates bone replication of preosteoblastic cells and enhances the differentiated function of the osteoblast The synthesis of skeletal IGF I is regulated by systemic hormones, most notably parathyroid hormone and glucocorticoids, as well as by locally produced factors, such as prostaglandins and other skeletal growth factors Whereas hormones and growth factors regulate IGF I synthesis, the exact level of regulation has not been established and may involve both transcriptional and posttranscriptional mechanisms The IGF I gene contains six exons, and both exon 1 and 2 contain transcription initiation sites Extrahepatic tissues, including bone, express exon 1 transcripts, and regulation of the exon 1 promoter activity in osteoblasts is currently under study It is apparent that the regulation of IGF I gene transcription as well as the regulation of mRNA stability is complex and tissue specific It is possible that abnormalities in skeletal IGF I synthesis or activity play a role in the pathogenesis of bone disorders In view of its important anabolic actions in bone, it is tempting to postulate the use of IGF I for the treatment of disorders characterized by decreased bone mass An alternative could be the stimulation of the local production of IGF I in bone

92 citations

Journal ArticleDOI
TL;DR: The ReACT study investigated whether the addition of rindopepimut to standard bevacizumab improved outcome for patients with relapsed, EGFRvIII-positive glioblastoma, and supported the potential for targeted immunotherapy among patients with GBM.
Abstract: Purpose: Rindopepimut is a vaccine targeting the tumor-specific EGF driver mutation, EGFRvIII. The ReACT study investigated whether the addition of rindopepimut to standard bevacizumab improved outcome for patients with relapsed, EGFRvIII-positive glioblastoma. Patients and Methods: In this double-blind, randomized, phase II study (NCT01498328) conducted at 26 hospitals in the United States, bevacizumab-naive patients with recurrent EGFRvIII-positive glioblastoma were randomized to receive rindopepimut or a control injection of keyhole limpet hemocyanin, each concurrent with bevacizumab. The primary endpoint was 6-month progression-free survival (PFS6) by central review with a one-sided significance of 0.2. Results: Between May 2012 and 2014, 73 patients were randomized (36 rindopepimut, 37 control). Rindopepimut toxicity included transient, low-grade local reactions. As primary endpoint, PFS6 was 28% (10/36) for rindopepimut compared with 16% (6/37) for control (P = 0.12, one-sided). Secondary and exploratory endpoints also favored the rindopepimut group including a statistically significant survival advantage [HR, 0.53; 95% confidence interval (CI), 0.32–0.88; two-sided log-rank P = 0.01], a higher ORR [30% (9/30) vs. 18% (6/34; P = 0.38)], median duration of response [7.8 months (95% CI, 3.5–22.2) vs. 5.6 (95% CI, 3.7–7.4)], and ability to discontinue steroids for ≥6 months [33% (6/18) vs. 0% (0/19)]. Eighty percent of rindopepimut-treated patients achieved robust anti-EGFRvIII titers (≥1:12,800), which were associated with prolonged survival (HR = 0.17; 95% CI, 0.07–0.45; P Conclusions: Our randomized trial supports the potential for targeted immunotherapy among patients with GBM, but the therapeutic benefit requires validation due to the small sample size and potential heterogeneity of bevacizumab response among recurrent patients with GBM.

92 citations

Journal ArticleDOI
07 Jun 2005-Langmuir
TL;DR: Four different self-assembled monolayer (SAM) electrode systems were examined electrochemically to better understand surface charge effects on the redox thermodynamics of immobilized horse heart cytochrome c (cyt c).
Abstract: Four different self-assembled monolayer (SAM) electrode systems were examined electrochemically in order to better understand surface charge effects on the redox thermodynamics of immobilized horse heart cytochrome c (cyt c). Neutralization of protein surface charge upon adsorption on anionic COOH-terminated SAMs was found to cause substantial changes in the formal potential, as determined by cyclic voltammetry. For cyt c immobilized on negatively charged surfaces, the formal potential shifted to more negative values as the ionic strength was decreased, which is opposite to the trend displayed by solution cyt c. In contrast, immobilization to uncharged interfaces resulted in an ionic strength dependence for cyt c that is similar to its solution behavior. The results provide insight into the importance of surface charge on the formal potential of cyt c.

92 citations


Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897