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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


Papers
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Journal ArticleDOI
TL;DR: This is the first study to show that lymph node biopsy is a safe procedure and can be undertaken with local experts in rural settings and provides a foundation for detailed immune response investigations during future clinical trials.
Abstract: HIV-1 rapidly establishes a persistent infection that can be contained under life-long antiretroviral therapy (ART) but not cured. One major viral reservoir is the peripheral lymph node (LN) follicles. Studying the impact of novel HIV-1 treatment and vaccination approaches on cells residing in germinal centers is essential for rapid progress towards HIV-1 prevention and cure. We enrolled 9 asymptomatic adult volunteers with a newly diagnosed HIV-1 infection and CD4 T cell counts ≥ 350/ml. The patients underwent venous blood collection and inguinal lymph node excision surgery in parallel. Mononuclear cells were extracted from blood and tissues simultaneously. Participants were followed up regularly for 2 weeks until complete healing of the surgical wounds. All participants completed the lymph node excision surgery without clinical complications. Among the 9 volunteers, one elite controller was identified. The number of mononuclear cells recovered from lymph nodes ranged from 68 to 206 million and correlated positively with lymph node size. This is the first study to show that lymph node biopsy is a safe procedure and can be undertaken with local experts in rural settings. It provides a foundation for detailed immune response investigations during future clinical trials.
Posted ContentDOI
18 Jul 2021-medRxiv
TL;DR: In this article, the authors performed a retrospective cross-sectional study where data were collected from medical records of adult patients (age >40 years), hospitalized with clinical diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a tertiary level University hospital in eastern Nepal from April 15 to October 15, 2014 were included.
Abstract: Background: Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) share a complex relationship with gender, risk, and co-morbidities. There is paucity of data on the gender-based differences in the prevalence of risks and co-morbidities in AECOPD in Nepal. Methods: We performed a retrospective cross-sectional study where data were collected from medical records of adult patients (age >40 years), hospitalized with clinical diagnosis of AECOPD in a tertiary level University hospital in eastern Nepal from April 15, 2014 to October 15, 2014 were included. Data analysis was performed by using SPSS software (Version 26.0, 2020; SPSS Inc., Chicago, IL). Results: Of the 256 patients with the primary diagnosis of AECOPD, mean age was 69 years and 65.63% (n=168) of hospitalizations were female population. Compared to males, 64.32 % (n=137) of active smokers were females p= 0.299, 76.19% (n=32) of diabetics were females p= 0.155, 72.86% (n=51) of hypertensive were females, p= 0.143, 50% (n= 6) of underlying Atrial fibrillation were in females p= 0.350, 57.50% (n= 23) of anemics were females p= 0.278, 100% (n= 3) of asthmatics were females p= 0.553, 44.44% (n= 8) of Pulmonary tuberculosis were in females p= 0.070, and 78.76% (n= 89) of indoor air pollution exposure was in females p <0.001. Conclusion: Females have higher association to indoor air pollution exposure compared to male and this association was found to be statistically significant. The higher incidence of AECOPD hospitalization in females can be explained by these findings. We need larger studies to validate these findings.
Journal ArticleDOI
TL;DR: The unique contributions the Center of Clinical Excellence and Professional Development, an acute care–based organization, has made to the state home care organization to improve patient outcomes across the continuum of care are described.
Abstract: This article describes the unique contributions the Center of Clinical Excellence and Profes- sional Development, an acute care-based organi- zation, has made to the state home care organiza- tion to improve patient outcomes across the con- tinuum of care. Although highly skilled in specialty areas, the clinical nurse specialists in the center have applied and transferred their acute care knowledge and expertise to the home care environment. The authors were doing this to ready the home care agencies for providing care to the most challenging of home care patients in a new payment system. Since 1999, six educational programs have been provided for staff. Many home care visits have been made with the home care nurse. This relationship has been a positive one for the center staff, for home care staff, and especially for patients. educator, consultant, researcher, and one who provides leadership. During a time when CNS positions were being elim- inated across the country and locally and academic pro- grams were transitioning from CNS to nurse practitio- ner, we were fortunate to have a core group of educators (four) who were CNS educated, looking to do things differently, and anxious to meet the challenge. We had one CNS in the women and children's division who maximized the role of the CNS. Her role would be our model. We began with five. These nurses were highly specialized, and there was a need in the medical center to have medical/surgical CNSs. Fortunately, we would have access to faculty from the school of nursing who would graduate its last class in June 1997. The decision was made to maximize the role of the CNS. Historically, the CNS had been a "project" person. This is not a category of worker who survives in a financially challenging environment. From an adminis- trative perspective, we could demonstrate the value of the CNS to an academic medical center based on the acuity of the patient population and staff needs that are never ending due to the rapidly changing technology. Four positions were added in the medical/surgical area. The requirement was for an APRN (advanced practice registered nurse) license and certification in a mini- mum of one clinical specialty. Two groups were in place, and it was time to work on developing one group. A retreat in the spring of 1996 was the beginning of the center. The philosophy developed that day has guided us in our practice. The philosophy of the center is to promote a model of excellence in collaborative clinical practice to opti-
Posted ContentDOI
13 Oct 2020-medRxiv
TL;DR: Investigation of the prevalence of dengue and chikungunya viruses in Kilombero district, South-Eastern Tanzania reveals the co-circulation of all four DENV serotypes and CHIKV, and reports the first occurrence of DENV-4 in Tanzania.
Abstract: Background Dengue and Chikungunya viruses can cause large-scale epidemics with attack rates exceeding 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent one in 2018 and 2019 mostly reported in coastal areas. Despite its importance, there is limited knowledge on epidemiology of dengue (DENV) and chikungunya (CHIKV) in Tanzania. This study was conducted to investigate the prevalence of DENV and CHIKV in Kilombero district, South-Eastern Tanzania. Methods A cross-sectional study was conducted at Kibaoni Health Center, in Kilombero district, in the rainy and dry seasons of 2018. Febrile patients of any age and gender were enrolled. Blood samples were taken and screened for DENV and CHIKV viral RNA by real-time RT-PCR assays. Results A total of 294 patients were recruited. Most were females (65%), and aged between 14⍰25 years (33%). DENV and CHIKV were detected in 29 (9.9%) and 3 (1.0%) patients, respectively. DENV was detected across all age groups and during both dry and rainy seasons. Although all four DENV serotypes were detected, serotypes 1 and 3 dominated and were present in 14 patients (42.4%) each. Additionally, the study showed DENV-1 and DENV-3 co-infections. Conclusion This study reveals the co-circulation of all four DENV serotypes and CHIKV in Kilombero district. Importantly, we report the first occurrence of DENV-4 in Tanzania. Unlike previous DENV outbreaks caused by DENV-2, the 2018 outbreak was dominated by DENV-1 and DENV-3. Occurrence of all serotypes suggests the possibility of having severe clinical outcomes in future DENV epidemics in Tanzania.

Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897