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Institution

Saint Francis University

EducationLoretto, Pennsylvania, United States
About: Saint Francis University is a education organization based out in Loretto, Pennsylvania, United States. It is known for research contribution in the topics: Population & Osteoblast. The organization has 1694 authors who have published 2038 publications receiving 87149 citations.


Papers
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Journal ArticleDOI
TL;DR: In conclusion, CTGF overexpression in vivo causes osteopenia, secondary to decreased bone formation, possibly by antagonizing BMP, Wnt, and IGF-I signaling and activity.
Abstract: Connective tissue growth factor (CTGF), a member of the CCN family of proteins, is expressed in skeletal cells, and the ctgf null mutation leads to neonatal lethality due to defects in skeletal development. To define the function of CTGF in the postnatal skeleton, we created transgenic mice overexpressing CTGF under the control of the human osteocalcin promoter. CTGF transgenic female and male mice exhibited a significant decrease in bone mineral density, compared with wild-type littermate controls. Bone histomorphometry revealed that CTGF overexpression caused decreased trabecular bone volume due to impaired osteoblastic activity because mineral apposition and bone formation rates were decreased. Osteoblast and osteoclast number and bone resorption were not altered. Calvarial osteoblasts and stromal cells from CTGF transgenics displayed decreased alkaline phosphatase and osteocalcin mRNA levels and reduced bone morphogenetic protein (BMP) signaling mothers against decapentaplegic, Wnt/β-catenin, and IGF-I/Akt signaling. In conclusion, CTGF overexpression in vivo causes osteopenia, secondary to decreased bone formation, possibly by antagonizing BMP, Wnt, and IGF-I signaling and activity.

45 citations

Journal ArticleDOI
TL;DR: For example, this paper found that the cold seems to be viewed as very much in the realm of a biomedical illness, with the exception of ascribing the hot/cold system of causality to the common cold, among all five populations.
Abstract: This paper focuses on conceptualizations of the common cold among Latin Americans, as compared with middle-class Americans. Four geographically dispersed groups of Latin Americans were chosen for study: Guatemalans in Guatemala; Mexicans in Guadalajara, Mexico; persons of Mexican descent in Edinburg, Texas (on the Texas-Mexican border); and Puerto Ricans in Hartford, Connecticut. In addition, a comparison group of middle-income Americans living in Tampa, Florida, was also studied to see the extent to which folk concepts were seen in what is considered to be a "mainstream" population. The data suggest a great deal of both intra- and intercultural agreement as to causes, symptoms, and treatments of the common cold. The cold seems to be viewed as very much in the realm of a biomedical illness, with the exception of ascribing the hot/cold system of causality to the common cold, among all five populations. Finally, the cold is clearly differentiated from "the flu," which seems to exist as an illness only among...

45 citations

Journal ArticleDOI
01 Aug 2000-Chest
TL;DR: Fluticasone propionate powder improved lung function when administered either qd or bid over a 1-year period to patients with moderate asthma, with twice- daily dosing demonstrating significantly greater improvement in some efficacy parameters than once-daily dosing over the first 12 weeks of treatment.

45 citations

Journal ArticleDOI
TL;DR: The usefulness of the pulse oximeter in making the diagnosis and the management of methemoglobinemia are discussed and the experience with the patient shows that intoxication can occur in children if the drug is applied to a large area of skin that has lost its integrity.
Abstract: We report a 2-year-old child who presented with severe methemoglobinemia after topical application of Lanacane (with 3% benzocaine). The experience with our patient shows that intoxication can occur in children if the drug is applied to a large area of skin that has lost its integrity. We discuss the usefulness of the pulse oximeter in making the diagnosis and review the management of methemoglobinemia.

45 citations

Journal ArticleDOI
TL;DR: Key findings demonstrate that Nodal is required in aggressive human breast cancer cells to activate ERK signaling and downstream tumorigenic phenotypes both in vitro and in vivo and suggest that the MAPK pathway is an important target for treating triple-negative breast cancers.

45 citations


Authors

Showing all 1697 results

NameH-indexPapersCitations
Steven M. Greenberg10548844587
Linus Pauling10053663412
Ernesto Canalis9833130085
John S. Gottdiener9431649248
Dalane W. Kitzman9347436501
Joseph F. Polak9140638083
Charles A. Boucher9054931769
Lawrence G. Raisz8231526147
Julius M. Gardin7625338063
Jeffrey S. Hyams7235722166
James J. Vredenburgh6528018037
Michael Centrella6212011936
Nathaniel Reichek6224822847
Gerard P. Aurigemma5921217127
Thomas L. McCarthy5710710167
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
20228
2021146
2020133
2019126
201897