Saint Louis University

About: Saint Louis University is a education organization based out in St Louis, Missouri, United States. It is known for research contribution in the topics: Population & Health care. The organization has 18927 authors who have published 34895 publications receiving 1267475 citations. The organization is also known as: SLU & St. Louis University.

Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

Abstract: Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by excess absorption of dietary iron and progressive iron deposition in several tissues, particularly liver. Liver disease resulting from iron toxicity is the major cause of death in HH. Hepatic iron loading in HH is progressive despite down-regulation of the classical transferrin receptor (TfR). Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein (TfR2) that binds holotransferrin and mediates uptake of transferrin-bound iron. We independently identified a full-length murine EST encoding the mouse orthologue of the human TfR2. Although homologous to murine TfR in the coding region, the TfR2 transcript does not contain the iron-responsive elements found in the 3' untranslated sequence of TfR mRNA. To determine the potential role for TfR2 in iron uptake by liver, we investigated TfR and TfR2 expression in normal mice and murine models of dietary iron overload (2% carbonyl iron), dietary iron deficiency (gastric parietal cell ablation), and HH (HFE -/-). Northern blot analyses demonstrated distinct tissue-specific patterns of expression for TfR and TfR2, with TfR2 expressed highly only in liver where TfR expression is low. In situ hybridization demonstrated abundant TfR2 expression in hepatocytes. In contrast to TfR, TfR2 expression in liver was not increased in iron deficiency. Furthermore, hepatic expression of TfR2 was not down-regulated with dietary iron loading or in the HFE -/- model of HH. From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.

The Pursuit of Unhappiness: The Elusive Psychology of Well-Being

Abstract: PART I: FUNDAMENTALS OF PRUDENTIAL PSYCHOLOGY 1. Taking Socrates's Question Seriously 2. Happiness, Well-Being, and the Good Life: A Primer 3. What Do We Want from a Theory of Happiness? Or how to make a mongrel concept hunt PART II: THE NATURE OF HAPPINESS 4. Hedonistic Theories of Happiness 5. Life Satisfaction Theories of Happiness 6. Emotional State Theories of Happiness 7. Happiness as Psychic Affirmation PART III: THE NATURE OF WELL-BEING 8. Well-Being and Virtue 9. Happiness, the Self, and Human Flourishing PART IV: PURSUING HAPPINESS 10. Do We Know How Happy We Are? 11. The Pursuit of Unhappiness 12. Happiness in Context: Notes on the Good Society