Institution
Saint Louis University
Education•St Louis, Missouri, United States•
About: Saint Louis University is a education organization based out in St Louis, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 18927 authors who have published 34895 publications receiving 1267475 citations. The organization is also known as: SLU & St. Louis University.
Topics: Population, Poison control, Health care, Transplantation, Virus
Papers published on a yearly basis
Papers
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TL;DR: Two major virus-specific RNA species were resolved in the cytoplasm of cultured human (KB) cells early after infection with adenovirus (Ad) type 2 and constitute a single class of RNA molecules whose transcription is not dependent upon virus specific early proteins.
224 citations
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University of Colorado Boulder1, Saint Louis University2, National Center for Atmospheric Research3, Paul Scherrer Institute4, University of Bern5, Rakuno Gakuen University6, University of Gothenburg7, Texas A&M University8, Brookhaven National Laboratory9, Pacific Northwest National Laboratory10, Desert Research Institute11, Massachusetts Institute of Technology12, Mexican Institute of Petroleum13
TL;DR: In this paper, the MI-LAGRO field campaign in Mexico City used a high resolution AMS spectra to identify a biomass burning organic aerosol component, which includes several large plumes that appear to be from forest fires within the region.
Abstract: Submicron aerosol was analyzed during the MI- LAGRO field campaign in March 2006 at the T0 urban su- persite in Mexico City with a High-Resolution Aerosol Mass Spectrometer (AMS) and complementary instrumentation. Positive Matrix Factorization (PMF) of high resolution AMS spectra identified a biomass burning organic aerosol (BBOA) component, which includes several large plumes that appear to be from forest fires within the region. Here, we show
224 citations
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TL;DR: The diagnosis of NASH requires a high index of suspicion, especially in obese patients over the age of 45 years who have diabetes, because these are the patients at greatest risk for developing cirrhosis.
224 citations
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TL;DR: A model of employment status (self-employed vs. wage-or-salary employed) choice based on psychological, sociological and cognitive variables resolves the traditional shortcomings of occupational tr... as mentioned in this paper.
Abstract: A model of employment status (self-employed vs. wage-or-salary employed) choice based on psychological, sociological and cognitive variables resolves the traditional shortcomings of occupational tr...
224 citations
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TL;DR: Inflammation potentially increases brain levels of Abeta by three mechanisms: increased influx, decreased efflux, and increased neuronal production.
Abstract: Alzheimer's disease (AD) brains are characterized by accumulation of amyloid beta protein (Abeta) and neuroinflammation. Increased blood-to-brain influx and decreased brain-to-blood efflux across the blood-brain barrier (BBB) have been proposed as mechanisms for Abeta accumulation. Epidemiological studies suggest that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows the progression of AD. We hypothesized that inflammation alters BBB handling of Abeta. Mice treated with lipopolysaccharide (LPS) had increased brain influx and decreased brain efflux of Abeta, recapitulating the findings in AD. Neither influx nor efflux was mediated by LPS acting directly on BBB cells. Increased influx was mediated by a blood-borne factor, indomethacin-independent, blocked by the triglyceride triolein, and not related to expression of the blood-to-brain transporter of Abeta, RAGE. Serum levels of IL-6, IL-10, IL-13, and MCP-1 mirrored changes in Abeta influx. Decreased efflux was blocked by indomethacin and accompanied by decreased protein expression of the brain-to-blood transporter of Abeta, LRP-1. LPS paradoxically increased expression of neuronal LRP-1, a major source of Abeta. Thus, inflammation potentially increases brain levels of Abeta by three mechanisms: increased influx, decreased efflux, and increased neuronal production.
223 citations
Authors
Showing all 19076 results
Name | H-index | Papers | Citations |
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Douglas G. Altman | 253 | 1001 | 680344 |
John E. Morley | 154 | 1377 | 97021 |
Roberto Romero | 151 | 1516 | 108321 |
Daniel S. Berman | 141 | 1363 | 86136 |
Gregory J. Gores | 141 | 686 | 66269 |
Thomas J. Smith | 140 | 1775 | 113919 |
Richard T. Lee | 131 | 810 | 62164 |
George K. Aghajanian | 121 | 277 | 48203 |
Reza Malekzadeh | 118 | 900 | 139272 |
Robert N. Weinreb | 117 | 1124 | 59101 |
Leslee J. Shaw | 116 | 808 | 61598 |
Thomas J. Ryan | 116 | 675 | 67462 |
Josep M. Llovet | 116 | 399 | 83871 |
Robert V. Farese | 115 | 473 | 48754 |
Michael Horowitz | 112 | 982 | 46952 |