Institution
Saint Louis University
Education•St Louis, Missouri, United States•
About: Saint Louis University is a education organization based out in St Louis, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 18927 authors who have published 34895 publications receiving 1267475 citations. The organization is also known as: SLU & St. Louis University.
Topics: Population, Poison control, Health care, Transplantation, Virus
Papers published on a yearly basis
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574 citations
TL;DR: It is shown that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase, which implicate this locus in the development of HCC and raise concerns over the clinical use of AAV vectors.
Abstract: Adeno-associated viruses (AAV) are promising gene therapy vectors that have little or no acute toxicity. We show that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase. AAV proviruses were isolated from four tumors and were all located within a 6-kilobase region of chromosome 12. This locus encodes several imprinted transcripts, small nucleolar RNAs (snoRNAs), and microRNAs. Transcripts from adjacent genes encoding snoRNAs and microRNAs were overexpressed in tumors. Our findings implicate this locus in the development of HCC and raise concerns over the clinical use of AAV vectors.
571 citations
Saint Louis University1, University of Barcelona2, Research Triangle Park3, Boston Medical Center4, Northwestern University5, University of Arkansas for Medical Sciences6, Charité7, University of Edinburgh8, National Institutes of Health9, University of California, Berkeley10, UCLA Medical Center11, Innsbruck Medical University12, McGill University13, University of California, San Francisco14, Sapienza University of Rome15, Wrocław Medical University16, Maastricht University Medical Centre17, NewYork–Presbyterian Hospital18
TL;DR: The Society for Sarcopenia, Cachexia, and Wasting Disease convened an expert panel to develop nutritional recommendations for prevention and management of sarcopenia.
570 citations
01 Oct 2005
TL;DR: In this paper, a study of 145 managers of a large biotechnology/agricultural company examined how leaders' emotion recognition ability and personality characteristics influenced performance of transformational transformation.
Abstract: This study of 145 managers of a large biotechnology/agricultural company examined how leaders' emotion recognition ability and personality characteristics influenced performance of transformational...
570 citations
TL;DR: This paper addresses clinical controversies and uncertainties regarding thoracic aortic aneurysm and its treatment, and identifies promising biomarkers, especially metalloproteinases, that can predict the onset of adverse events.
569 citations
Authors
Showing all 19076 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas G. Altman | 253 | 1001 | 680344 |
| John E. Morley | 154 | 1377 | 97021 |
| Roberto Romero | 151 | 1516 | 108321 |
| Daniel S. Berman | 141 | 1363 | 86136 |
| Gregory J. Gores | 141 | 686 | 66269 |
| Thomas J. Smith | 140 | 1775 | 113919 |
| Richard T. Lee | 131 | 810 | 62164 |
| George K. Aghajanian | 121 | 277 | 48203 |
| Reza Malekzadeh | 118 | 900 | 139272 |
| Robert N. Weinreb | 117 | 1124 | 59101 |
| Leslee J. Shaw | 116 | 808 | 61598 |
| Thomas J. Ryan | 116 | 675 | 67462 |
| Josep M. Llovet | 116 | 399 | 83871 |
| Robert V. Farese | 115 | 473 | 48754 |
| Michael Horowitz | 112 | 982 | 46952 |