Showing papers by "San Diego State University published in 2007"
TL;DR: The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health.
Abstract: Summary—In 1995 the American College of Sports Medicine and the Centers for Disease Control and Prevention published national guidelines on Physical Activity and Public Health The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health Development of this document was by an expert panel of scientists, including physicians, epidemiologists, exercise scientists, and public health specialists This panel reviewed advances in pertinent physiologic, epidemiologic, and clinical scientific data, including primary research articles and reviews published since the original recommendation was issued in 1995 Issues considered by the panel included new scientific evidence relating physical activity to health, physical activity recommendations by various organizations in the interim, and communications issues Key points related to updating the physical activity recommendation were outlined and writing groups were formed A draft manuscript was prepared and circulated for review to the expert panel as well as to outside experts Comments were integrated into the final recommendation Primary Recommendation—To promote and maintain health, all healthy adults aged 18 to 65 yr need moderate-intensity aerobic (endurance) physical activity for a minimum of 30 min on five days each week or vigorous-intensity aerobic physical activity for a minimum of 20 min on three days each week [I (A)] Combinations of moderate- and vigorous-intensity activity can be performed to meet this recommendation [IIa (B)] For example, a person can meet the recommendation by walking briskly for 30 min twice during the week and then jogging for 20 min on two other days Moderate-intensity aerobic activity, which is generally equivalent to a brisk walk and noticeably accelerates the heart rate, can be accumulated toward the 30-min minimum by performing bouts each lasting 10 or more minutes [I (B)] Vigorous-intensity activity is exemplified by jogging, and causes rapid breathing and a substantial increase in heart rate In addition, every adult should perform activities that maintain or increase muscular strength and endurance a minimum of two days each week [IIa (A)] Because of the dose-response relation between physical activity and health, persons who wish to further improve their personal fitness, reduce their risk for chronic diseases and disabilities or prevent unhealthy weight gain may benefit by exceeding the minimum recommended amounts of physical activity [I (A)] (Circulation 2007;116:1081-1093)
6,863 citations
TL;DR: The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health.
Abstract: Summary: In 1995 the American College of Sports Medicine and the Centers for Disease Control and Prevention published national guidelines on Physical Activity and Public Health. The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations. The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health. Development of this document was by an expert panel of scientists, including physicians, epidemiologists, exercise scientists, and public health specialists. This panel reviewed advances in pertinent physiologic, epidemiologic, and clinical scientific data, including primary research articles and reviews published since the original recommendation was issued in 1995. Issues considered by the panel included new scientific evidence relating physical activity to health, physical activity recommendations by various organizations in the interim, and communications issues. Key points related to updating the physical activity recommendation were outlined and writing groups were formed. A draft manuscript was prepared and circulated for review to the expert panel as well as to outside experts. Comments were integrated into the final recommendation.
Primary Recommendation: To promote and maintain health, all healthy adults aged 18 to 65 yr need moderate-intensity aerobic (endurance) physical activity for a minimum of 30 min on five days each week or vigorous-intensity aerobic physical activity for a minimum of 20 min on three days each week. [I (A)] Combinations of moderate- and vigorous-intensity activity can be performed to meet this recommendation. [IIa (B)] For example, a person can meet the recommendation by walking briskly for 30 min twice during the week and then jogging for 20 min on two other days. Moderate-intensity aerobic activity, which is generally equivalent to a brisk walk and noticeably accelerates the heart rate, can be accumulated toward the 30-min minimum by performing bouts each lasting 10 or more minutes. [I (B)] Vigorous-intensity activity is exemplified by jogging, and causes rapid breathing and a substantial increase in heart rate. In addition, every adult should perform activities that maintain or increase muscular strength and endurance a minimum of two days each week. [IIa (A)] Because of the dose-response relation between physical activity and health, persons who wish to further improve their personal fitness, reduce their risk for chronic diseases and disabilities or prevent unhealthy weight gain may benefit by exceeding the minimum recommended amounts of physical activity. [I (A)]
4,320 citations
TL;DR: It is shown that applying qualitative and quantitative measures to the same data set can lead to dramatically different conclusions about the main factors that structure microbial diversity and can provide insight into the nature of community differences.
Abstract: The assessment of microbial diversity and distribution is a major concern in environmental microbiology. There are two general approaches for measuring community diversity: quantitative measures, which use the abundance of each taxon, and qualitative measures, which use only the presence/absence of data. Quantitative measures are ideally suited to revealing community differences that are due to changes in relative taxon abundance (e.g., when a particular set of taxa flourish because a limiting nutrient source becomes abundant). Qualitative measures are most informative when communities differ primarily by what can live in them (e.g., at high temperatures), in part because abundance information can obscure significant patterns of variation in which taxa are present. We illustrate these principles using two 16S rRNA-based surveys of microbial populations and two phylogenetic measures of community β diversity: unweighted UniFrac, a qualitative measure, and weighted UniFrac, a new quantitative measure, which we have added to the UniFrac website (http://bmf.colorado.edu/unifrac). These studies considered the relative influences of mineral chemistry, temperature, and geography on microbial community composition in acidic thermal springs in Yellowstone National Park and the influences of obesity and kinship on microbial community composition in the mouse gut. We show that applying qualitative and quantitative measures to the same data set can lead to dramatically different conclusions about the main factors that structure microbial diversity and can provide insight into the nature of community differences. We also demonstrate that both weighted and unweighted UniFrac measurements are robust to the methods used to build the underlying phylogeny.
1,927 citations
TL;DR: The recommendation for older adults is similar to the updated ACSM/AHA recommendation for adults, but has several important differences including: the recommended intensity of aerobic activity takes into account the older adult's aerobic fitness; activities that maintain or increase flexibility are recommended; and balance exercises are recommended for Older adults at risk of falls.
Abstract: Objective:To issue a recommendation on the types and amounts of physical activity needed to improve and maintain health in older adults.Participants:A panel of scientists with expertise in public health, behavioral science, epidemiology, exercise science, medicine, and gerontology.Evidence:T
1,720 citations
TL;DR: The data suggest that compared with a no-treatment control, brief training in mindfulness meditation or somatic relaxation reduces distress and improves positive mood states, and mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors.
Abstract: Background: Although mindfulness meditation interventions have recently shown benefits for reducing stress in various populations, little is known about their relative efficacy compared with relaxation interventions.Purpose: This randomized controlled trial examines the effects of a 1-month mindfulness meditation versus somatic relaxation training as compared to a control group in 83 students (M age=25; 16 men and 67 women) reporting distress.Method: Psychological distress, positive states of mind, distractive and ruminative thoughts and behaviors, and spiritual experience were measured, while controlling for social desirability.Results: Hierarchical linear modeling reveals that both meditation and relaxation groups experienced significant decreases in distress as well as increases in positive mood states over time, compared with the control group (p<.05 in all cases). There were no significant differences between meditation and relaxation on distress and positive mood states over time. Effect sizes for distress were large for both meditation and relaxation (Cohen’s d=1.36 and .91, respectively), whereas the meditation group showed a larger effect size for positive states of mind than relaxation (Cohen’s d=.71 and .25, respectively). The meditation group also demonstrated significant pre-post decreases in both distractive and ruminative thoughts/behaviors compared with the control group (p<.04 in all cases; Cohen’s d=.57 for rumination and .25 for distraction for the meditation group), with mediation models suggesting that mindfulness meditation’s effects on reducing distress were partially mediated by reducing rumination. No significant effects were found for spiritual experience.Conclusions: The data suggest that compared with a no-treatment control, brief training in mindfulness meditation or somatic relaxation reduces distress and improves positive mood states. However, mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors, and this ability may provide a unique mechanism by which mindfulness meditation reduces distress.
1,209 citations
TL;DR: Social exclusion caused a substantial reduction in prosocial behavior and the implication is that rejection temporarily interferes with emotional responses, thereby impairing the capacity for empathic understanding of others and as a result, any inclination to help or cooperate with them is undermined.
Abstract: In 7 experiments, the authors manipulated social exclusion by telling people that they would end up alone later in life or that other participants had rejected them. Social exclusion caused a substantial reduction in prosocial behavior. Socially excluded people donated less money to a student fund, were unwilling to volunteer for further lab experiments, were less helpful after a mishap, and cooperated less in a mixed-motive game with another student. The results did not vary by cost to the self or by recipient of the help, and results remained significant when the experimenter was unaware of condition. The effect was mediated by feelings of empathy for another person but was not mediated by mood, state self-esteem, belongingness, trust, control, or self-awareness. The implication is that rejection temporarily interferes with emotional responses, thereby impairing the capacity for empathic understanding of others, and as a result, any inclination to help or cooperate with them is undermined.
1,042 citations
TL;DR: Nosek et al. as mentioned in this paper investigated the role of implicit bias in the development of implicit mental health disorders and found that implicit bias was associated with depression and suicidal ideation.
Abstract: Correspondence should be addressed to Brian A. Nosek, Department of Psychology, University of Virginia, 102 Gilmer Hall, Box 400400, Charlottesville, VA 22904, USA. E-mail: nosek@virginia.edu This research was supported by the National Institute of Mental Health (MH-41328, MH-01533, MH-57672, and MH-68447) and the National Science Foundation (SBR-9422241, SBR-9709924, and REC-0634041). The authors are grateful for technical support from N. Sriram, Ethan Sutin, and Lili Wu. Related information is available at http://briannosek.com/ and http://projectimplicit.net/ EUROPEAN REVIEW OF SOCIAL PSYCHOLOGY 2007, 1 – 53, iFirst article
920 citations
TL;DR: The NEMS-S tool was found to have a high degree of inter-rater and test-retest reliability, and to reveal significant differences across store types and neighborhoods of high and low socioeconomic status.
719 citations
TL;DR: In this paper, a review of eHealth intervention studies for adults and children that targeted behavior change for physical activity, healthy eating, or both behaviors is presented, where participants interacted with some type of electronic technology either as the main intervention or an adjunct component.
627 citations
TL;DR: A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and visuoconstructional abilities.
Abstract: This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and visuoconstructional abilities. The neuropsychological deficits associated with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics (e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence.
605 citations
TL;DR: The physical environment attributes that make up the walkability index are potentially important candidate factors for future environmental and policy initiatives designed to increase physical activity.
TL;DR: A metabolic and taxonomic snapshot of microbes associated with the reef-building coral Porites astreoides is provided and presents a basis for understanding how coral-microbial interactions structure the holobiont and coral reefs.
Abstract: The coral holobiont is a dynamic assemblage of the coral animal, zooxanthellae, endolithic algae and fungi, Bacteria,Archaea and viruses Zooxanthellae and some Bacteria form relatively stable and species-specific associations with corals Other associations are less specific; coral-associated Archaea differ from those in the water column, but the same archaeal species may be found on different coral species It has been hypothesized that the coral animal can adapt to differing ecological niches by 'switching' its microbial associates In the case of corals and zooxanthellae, this has been termed adaptive bleaching and it has important implications for carbon cycling within the coral holobiont and ultimately the survival of coral reefs However, the roles of other components of the coral holobiont are essentially unknown To better understand these other coral associates, a fractionation procedure was used to separate the microbes, mitochondria and viruses from the coral animal cells and zooxanthellae The resulting metagenomic DNA was sequenced using pyrosequencing Fungi, Bacteria and phage were the most commonly identified organisms in the metagenome Three of the four fungal phyla were represented, including a wide diversity of fungal genes involved in carbon and nitrogen metabolism, suggesting that the endolithic community is more important than previously appreciated In particular, the data suggested that endolithic fungi could be converting nitrate and nitrite to ammonia, which would enable fixed nitrogen to cycle within the coral holobiont The most prominent bacterial groups were Proteobacteria (68%), Firmicutes (10%), Cyanobacteria (7%) and Actinobacteria (6%) Functionally, the bacterial community was primarily heterotrophic and included a number of pathways for the degradation of aromatic compounds, the most abundant being the homogentisate pathway The most abundant phage family was the ssDNA Microphage and most of the eukaryotic viruses were most closely related to those known to infect aquatic organisms This study provides a metabolic and taxonomic snapshot of microbes associated with the reef-building coral Porites astreoides and presents a basis for understanding how coral-microbial interactions structure the holobiont and coral reefs
TL;DR: In this first study to comprehensively survey viral communities using a metagenomic approach, it is found that soil viruses are taxonomically diverse and distinct from the communities of viruses found in other environments that have been surveyed using a similar approach.
Abstract: Recent studies have highlighted the surprising richness of soil bacterial communities; however, bacteria are not the only microorganisms found in soil. To our knowledge, no study has compared the diversities of the four major microbial taxa, i.e., bacteria, archaea, fungi, and viruses, from an individual soil sample. We used metagenomic and small-subunit RNA-based sequence analysis techniques to compare the estimated richness and evenness of these groups in prairie, desert, and rainforest soils. By grouping sequences at the 97% sequence similarity level (an operational taxonomic unit [OTU]), we found that the archaeal and fungal communities were consistently less even than the bacterial communities. Although total richness levels are difficult to estimate with a high degree of certainty, the estimated number of unique archaeal or fungal OTUs appears to rival or exceed the number of unique bacterial OTUs in each of the collected soils. In this first study to comprehensively survey viral communities using a metagenomic approach, we found that soil viruses are taxonomically diverse and distinct from the communities of viruses found in other environments that have been surveyed using a similar approach. Within each of the four microbial groups, we observed minimal taxonomic overlap between sites, suggesting that soil archaea, bacteria, fungi, and viruses are globally as well as locally diverse.
TL;DR: Cyclic voltammetry studies are reported for two representative quinones, benzoquinone and 2-anthraquinonesulfonate, in buffered and unbuffered aqueous solution at different pH's to unify quinone electrochemistry by bridging the apparent gap between the redox chemistry of quinONES in water and that in aprotic organic solvents.
Abstract: Cyclic voltammetry studies are reported for two representative quinones, benzoquinone and 2-anthraquinonesulfonate, in buffered and unbuffered aqueous solution at different pH's. While the redox reaction of quinones in buffered water is well described as an overall 2 e-, 2 H+ reduction to make the hydroquinone, a much better description of the overall reaction in unbuffered water is as a 2 e- reduction to make the strongly hydrogen-bonded quinone dianion, which will exist in water as an equilibrium mixture of protonation states. This description helps to unify quinone electrochemistry by bridging the apparent gap between the redox chemistry of quinones in water and that in aprotic organic solvents, where quinones undergo two sequential 1 e- reductions to form the quinone dianion.
TL;DR: The aim of this study was to estimate the age-, gender-, and ethnic-specific burden of PAD in the United States for the year 2000, and it is conservatively estimated that at least 6.8 million individuals aged 40 years or older had PAD by 2000.
TL;DR: This article summarizes the results of the workshop on Visualization, Analytics & Spatial Decision Support, which took place at the GIScience conference in September 2006, and suggests a new research direction ‘Geovisual Analytics for Spatial decision Support’, which emphasizes the importance of visualization and interactive visual interfaces and the link with the emerging research discipline of Visual Analytics.
Abstract: This article summarizes the results of the workshop on Visualization, Analytics & Spatial Decision Support, which took place at the GIScience conference in September 2006. The discussions at the workshop and analysis of the state of the art have revealed a need in concerted cross-disciplinary efforts to achieve substantial progress in supporting space-related decision making. The size and complexity of real-life problems together with their ill-defined nature call for a true synergy between the power of computational techniques and the human capabilities to analyze, envision, reason, and deliberate. Existing methods and tools are yet far from enabling this synergy. Appropriate methods can only appear as a result of a focused research based on the achievements in the fields of geovisualization and information visualization, human-computer interaction, geographic information science, operations research, data mining and machine learning, decision science, cognitive science, and other disciplines. The name 'Geovisual Analytics for Spatial Decision Support' suggested for this new research direction emphasizes the importance of visualization and interactive visual interfaces and the link with the emerging research discipline of Visual Analytics. This article, as well as the whole special issue, is meant to attract the attention of scientists with relevant expertise and interests to the major challenges requiring multidisciplinary efforts and to promote the establishment of a dedicated research community where an appropriate range of competences is combined with an appropriate breadth of thinking.
TL;DR: This work provides the first demonstration that exposure to word forms in a statistical word segmentation task facilitates subsequent word learning, and prior segmentation opportunities, but not mere frequency of exposure, facilitated infants learning of object labels.
Abstract: The present experiments investigated how the process of statistically segmenting words from fluent speech is linked to the process of mapping meanings to words. Seventeen-month-old infants first participated in a statistical word segmentation task, which was immediately followed by an object-label-learning task. Infants presented with labels that were words in the fluent speech used in the segmentation task were able to learn the object labels. However, infants presented with labels consisting of novel syllable sequences (nonwords; Experiment 1) or familiar sequences with low internal probabilities (part-words; Experiment 2) did not learn the labels. Thus, prior segmentation opportunities, but not mere frequency of exposure, facilitated infants∗ learning of object labels. This work provides the first demonstration that exposure to word forms in a statistical word segmentation task facilitates subsequent word learning.
TL;DR: In this article, the effect of milling time (up to 48 hours) on the morphological development of the powders and dispersion of CNTs was investigated, and the results show that the technique is effective in dispersing the nanotubes within the soft Al matrix.
Abstract: In the present work, we use mechanical alloying (MA) for the first time to generate a homogenous distribution of 2 wt% CNT within Al powders. The effect of milling time (up to 48 h) on the morphological development of the powders and dispersion of CNTs was investigated. The results show that the technique is effective in dispersing the nanotubes within the soft Al matrix which simultaneously protects the nanotubes from damage under the impact of the milling balls. The results can have important implications for the processing of CNT-reinforced metal-matrix composites in general.
TL;DR: In this article, the status of EOR theory is discussed and the assumptions associated with popular frameworks, including who is party to the relationship, the norm of reciprocity as a functioning rule, and the value of the resources exchanged.
TL;DR: In this article, the authors explore the properties of hadronic matter under extreme conditions of temperature and density, and the determination of the equation of state, the relation between pressure, temperature, and density of such matter.
TL;DR: A meta-analysis of the difference in nonword repetition performance between children with and without specific language impairment found that children with SLI displayed difficulty repeating even short nonwords, with greater difficulty for long nonwords.
Abstract: Purpose This study presents a meta-analysis of the difference in nonword repetition performance between children with and without specific language impairment (SLI). The authors investigated variability in the effect sizes (i.e., the magnitude of the difference between children with and without SLI) across studies and its relation to several factors: type of nonword repetition task, age of SLI sample, and nonword length. Method The authors searched computerized databases and reference sections and requested unpublished data to find reports of nonword repetition tasks comparing children with and without SLI. Results Children with SLI exhibited very large impairments in nonword repetition, performing an average (across 23 studies) of 1.27 standard deviations below children without SLI. A moderator analysis revealed that different versions of the nonword repetition task yielded significantly different effect sizes, indicating that the measures are not interchangeable. The second moderator analysis found no a...
TL;DR: The role of mitochondria in the control of cell death in cardiac myocytes is discussed, including the release of factors such as cytochrome c, Smac, Omi/Htr2A, and AIF from mitochondria serves to activate a highly complex and regulated cell death program.
Abstract: Mitochondria are important generators of energy, providing ATP through oxidative phosphorylation. However, mitochondria also monitor complex information from the environment and intracellular milieu, including the presence or absence of growth factors, oxygen, reactive oxygen species, and DNA damage. Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The release of factors such as cytochrome c, Smac, Omi/Htr2A, and AIF from mitochondria serves to activate a highly complex and regulated cell death program. Furthermore, mitochondrial calcium overload might trigger opening of the mitochondrial permeability transition pore, causing uncoupling of oxidative phosphorylation, swelling of the mitochondria due to influx of water, and rupture of the mitochondrial outer membrane. In this review, we discuss the role of mitochondria in the control of cell death in cardiac myocytes.
TL;DR: Whether the scientific evidence supports these proposed mechanisms and what future research directions may clarify or test these hypotheses regarding the relationship between long sleep and mortality is considered.
TL;DR: This paper found that a strong market orientation helps facilitate a balance between incremental and radical innovation by shifting firms' innovation priority more toward radical innovation activities and also suggests that the abandonment of traditional conceptualizations and measures of market orientation are premature.
TL;DR: In this paper, a study of the Type IIn supernova (SN) 2005gl, in the relatively nearby (d ≈ 66 Mpc) galaxy NGC 266, is presented, where a pre-explosion Hubble Space Telescope (HST) imaging of the location of the SN, along with a precise localization of this event using the laser guide star assisted adaptive adaptive optics (LGS-AO) system at Keck Observatory, are combined to identify a luminous (M_V = -10.3 mag) point source as the possible progenitor
Abstract: We present a study of the Type IIn supernova (SN) 2005gl, in the relatively nearby (d ≈ 66 Mpc) galaxy NGC 266. Photometry and spectroscopy of the SN indicate that it is a typical member of its class. Pre-explosion Hubble Space Telescope (HST) imaging of the location of the SN, along with a precise localization of this event using the laser guide star assisted adaptive optics (LGS-AO) system at Keck Observatory, are combined to identify a luminous (M_V = -10.3 mag) point source as the possible progenitor of SN 2005gl. If the source is indeed a single star, it was likely a member of the class of luminous blue variable stars (LBVs). This finding leads us to consider the possible general association of SNe IIn with LBV progenitors; it is indeed supported by observations of other SNe, and the known properties of LBV stars. For example, we argue that should the prototypical Galactic LBV η Carina explode in a phase similar to its current state, it will likely produce a SN IIn. We discuss our findings in the context of current ideas about the evolution of massive stars and review the census of SNe with identified progenitors. The concept of the progenitor-SN map is introduced as a convenient means to discuss the present status and future prospects of direct searches for SN progenitors. We conclude that this field has matured considerably in recent years, and the transition from anecdotal information about rare single events to robust associations of progenitor classes with specific SN types has already begun.
TL;DR: A meta-analysis of 175 studies of stalking is reported in this paper in which descriptive estimates of prevalence, sex differences, relationship origins, motives, threat and violence are provided, and the moderating effects of type of sample are examined.
TL;DR: The results indicate that BMCs engraft, survive, and grow within the spared myocardium after infarction by forming junctional complexes with resident myocytes, and BMCs transdifferentiate and acquire the cardiomyogenic and vascular phenotypes restoring the infarcted heart.
Abstract: The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after infarction has been challenged, and the notion of BMC transdifferentiation has been questioned. The center of the controversy is the lack of unequivocal evidence in favor of myocardial regeneration by the injection of BMCs in the infarcted heart. Because of the interest in cell-based therapy for heart failure, several approaches including gene reporter assay, genetic tagging, cell genotyping, PCR-based detection of donor genes, and direct immunofluorescence with quantum dots were used to prove or disprove BMC transdifferentiation. Our results indicate that BMCs engraft, survive, and grow within the spared myocardium after infarction by forming junctional complexes with resident myocytes. BMCs and myocytes express at their interface connexin 43 and N-cadherin, and this interaction may be critical for BMCs to adopt the cardiomyogenic fate. With time, a large number of myocytes and coronary vessels are generated. Myocytes show a diploid DNA content and carry, at most, two sex chromosomes. Old and new myocytes show synchronicity in calcium transients, providing strong evidence in favor of the functional coupling of these two cell populations. Thus, BMCs transdifferentiate and acquire the cardiomyogenic and vascular phenotypes restoring the infarcted heart. Together, our studies reveal that locally delivered BMCs generate de novo myocardium composed of integrated cardiomyocytes and coronary vessels. This process occurs independently of cell fusion and ameliorates structurally and functionally the outcome of the heart after infarction.
TL;DR: The NEMS-R has evidence of reliability, can discriminate restaurant types, and can be used in research and practice to characterize restaurant environments.
TL;DR: Non-Hispanic blacks and Hispanics were more inactive during their leisure time than were non-Hispanic whites, and social class but not occupational physical activity seems to moderate the relationship between race/ethnicity and leisure-time physical inactivity.
Abstract: Purpose: The aims of this study were to determine 1) prevalence of leisure-time physical inactivity in a nationally representative sample of non-Hispanic white, non-Hispanic black, and Hispanic men and women; 2) prevalence of leisure-time inactivity by racial/ethnic group across social class indicators; and 3) the relationship between leisure-time inactivity and occupational physical activity, independent of other social class indicators. Methods: The National Physical Activity and Weight Loss Survey was a telephone survey of noninstitutionalized U.S. adults (4695 men, 6516 women) conducted by random digit dialing between September and December 2002. Self-reported physical activity was assessed using questions from the 2001 Behavioral Risk Factor Surveillance System. Respondents who reported no moderate- or vigorous-intensity physical activity during leisure time in a usual week were classified as inactive. Indicators of social class were education, family income, employment status, and marital status. Results: Age-adjusted prevalence of leisure-time inactivity was 9.9% +/- 0.6 SE (standard error) and 12.0 +/- 0.6 for white men and women, respectively; 19.0 +/- 2.5 and 25.2 +/- 2.1 for non-Hispanic black men and women, and 20.9 +/- 2.1 and 27.3 +/- 2.5 for Hispanic men and women. Within each racial/ethnic group, prevalence of leisure-time inactivity was highest among participants of lower social class. Differences in inactivity by racial/ethnic group were less evident after adjustment for social class. Odds of inactivity were similar across quartiles of occupational physical activity after adjustment for age, sex, and social class. Conclusions: Non-Hispanic blacks and Hispanics were more inactive during their leisure time than were non-Hispanic whites. Social class but not occupational physical activity seems to moderate the relationship between race/ethnicity and leisure-time physical inactivity.
TL;DR: The results suggest that fetal alcohol exposure should be considered a possible factor in the pathogenesis of childhood psychiatric disorders.
Abstract: OBJECTIVE. This study compared the prevalence of psychopathological conditions in children with heavy prenatal alcohol exposure (N = 39) and nonexposed, typically developing peers (N = 30), matched with respect to age, gender, and socioeconomic status. METHODS. Caregivers were interviewed with either the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version, or the Computerized Diagnostic Interview Schedule for Children, Version IV. Statistical resampling methods were used to create 95% confidence intervals for the difference between the proportions of children with psychopathological conditions in the exposed and control groups. RESULTS. Group differences were seen in the attention-deficit/hyperactivity disorder, depressive disorders, oppositional defiant disorder, conduct disorder, and specific phobia outcome categories. The group difference in the attention-deficit/hyperactivity disorder category was by far the largest effect observed. CONCLUSIONS. These results suggest that fetal alcohol exposure should be considered a possible factor in the pathogenesis of childhood psychiatric disorders. These data provide clinically relevant information about the mental health problems that children with fetal alcohol exposure are likely to face.