San Diego State University

About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.

The mass of the black hole in cygnus x-1

Abstract: Cygnus X-1 is a binary star system that is comprised of a black hole and a massive giant companion star in a tight orbit. Building on our accurate distance measurement reported in the preceding paper, we first determine the radius of the companion star, thereby constraining the scale of the binary system. To obtain a full dynamical model of the binary, we use an extensive collection of optical photometric and spectroscopic data taken from the literature. By usingalloftheavailableobservationalconstraints,weshowthattheorbitisslightlyeccentric(boththeradialvelocity and photometric data independently confirm this result) and that the companion star rotates roughly 1.4 times its pseudosynchronous value. We find a black hole mass of M = 14.8 ± 1.0 M� , a companion mass of Mopt = 19.2 ± 1.9 M� , and the angle of inclination of the orbital plane to our line of sight of i = 27.1 ± 0. 8d eg.

Healthcare barriers of refugees post-resettlement

Abstract: The majority of refugees spend the greater part of their lives in refugee camps before repatriation or resettlement to a host country. Limited resources and stress during residence in refugee camps can lead to a variety of acute and chronic diseases which often persist upon resettlement. However, for most resettled refugees little is known about their health needs beyond a health assessment completed upon entry. We conducted a qualitative pilot-study in San Diego County, the third largest area in California, USA for resettling refugees, to explore health care access issues of refugees after governmental assistance has ended. A total of 40 guided in-depth interviews were conducted with a targeted sample of informants (health care practitioners, employees of refugee serving organizations, and recent refugee arrivals) familiar with the health needs of refugees. Interviews revealed that the majority of refugees do not regularly access health services. Beyond individual issues, emerging themes indicated that language and communication affect all stages of health care access—from making an appointment to filling out a prescription. Acculturation presented increased stress, isolation, and new responsibilities. Additionally, cultural beliefs about health care directly affected refugees’ expectation of care. These barriers contribute to delayed care and may directly influence refugee short- and long-term health. Our findings suggest the need for additional research into contextual factors surrounding health care access barriers, and the best avenues to reduce such barriers and facilitate access to existing services.

β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo

Abstract: Current therapeutic approaches to cancer are designed to target molecules that contribute to malignant behavior but leave normal tissues intact. beta(1) integrin is a candidate target well known for mediating cell-extracellular matrix (ECM) interactions that influence diverse cellular functions; its aberrant expression has been implicated in breast cancer progression and resistance to cytotoxic therapy. The addition of beta(1) integrin inhibitory agents to breast cancer cells at a single-cell stage in a laminin-rich ECM (three-dimensional lrECM) culture was shown to down-modulate beta(1) integrin signaling, resulting in malignant reversion. To investigate beta(1) integrin as a therapeutic target, we modified the three-dimensional lrECM protocol to approximate the clinical situation: before treatment, we allowed nonmalignant cells to form organized acinar structures and malignant cells to form tumor-like colonies. We then tested the ability of beta(1) integrin inhibitory antibody, AIIB2, to inhibit tumor cell growth in several breast cancer cell lines (T4-2, MDA-MB-231, BT474, SKBR3, and MCF-7) and one nonmalignant cell line (S-1). We show that beta(1) integrin inhibition resulted in a significant loss of cancer cells, associated with a decrease in proliferation and increase in apoptosis, and a global change in the composition of residual colonies. In contrast, nonmalignant cells that formed tissue-like structures remained resistant. Moreover, these cancer cell-specific antiproliferative and proapoptotic effects were confirmed in vivo with no discernible toxicity to animals. Our findings indicate that beta(1) integrin is a promising therapeutic target, and that the three-dimensional lrECM culture assay can be used to effectively distinguish malignant and normal tissue response to therapy.

Understanding child bilingual acquisition using parent and teacher reports

Abstract: There is limited research regarding what levels of proficiency in each language should characterize the language behavior of bilingual children and the impact of language exposure or language use variables on bilingual performance. This study was designed to examine the extent to which years of exposure to a language(s), amount of language input at home and at school, and amount of exposure to reading and other literacy activities in a language(s) relate to observed bilingual performance in young children, as obtained from parent and teacher reports. A secondary goal was to determine the extent to which parents or teachers could assist in determining language status by examining relationships between their ratings of the child's use and proficiency in the two languages and the child's grammatical performance. Fifty-seven children and their families were sampled from second grade classes of a large school district serving primarily low-income families in southern California. Multiple regression analyses for each language indicated that amount of Spanish input at home was a significant predictor of grammatical performance in that language. These input effects did not hold for English. Although there were some crosslinguistic differences, parent and teacher ratings of use and proficiency correlated with the child's grammatical performance in the target language. The findings suggest that parent and teacher estimates may be useful to determine bilingual status.

What is a TOT? Cognate and translation effects on tip-of-the-tongue states in Spanish-English and tagalog-English bilinguals.

Abstract: The authors induced tip-of-the-tongue states (TOTs) for English words in monolinguals and bilinguals using picture stimuli with cognate (e.g., vampire, which is vampiro in Spanish) and noncognate (e.g., funnel, which is embudo in Spanish) names. Bilinguals had more TOTs than did monolinguals unless the target pictures had translatable cognate names, and bilinguals had fewer TOTs for noncognates they were later able to translate. TOT rates for the same targets in monolinguals indicated that these effects could not be attributed to target difficulty. Two popular TOT accounts must be modified to explain cognate and translatability facilitation effects, and cross-language interference cannot explain bilinguals' increased TOTs rates. Instead the authors propose that, relative to monolinguals, bilinguals are less able to activate representations specific to each language.