Institution
San Diego State University
Education•San Diego, California, United States•
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.
Topics: Population, Poison control, Health care, Mental health, Public health
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results indicate that BMCs engraft, survive, and grow within the spared myocardium after infarction by forming junctional complexes with resident myocytes, and BMCs transdifferentiate and acquire the cardiomyogenic and vascular phenotypes restoring the infarcted heart.
Abstract: The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after infarction has been challenged, and the notion of BMC transdifferentiation has been questioned. The center of the controversy is the lack of unequivocal evidence in favor of myocardial regeneration by the injection of BMCs in the infarcted heart. Because of the interest in cell-based therapy for heart failure, several approaches including gene reporter assay, genetic tagging, cell genotyping, PCR-based detection of donor genes, and direct immunofluorescence with quantum dots were used to prove or disprove BMC transdifferentiation. Our results indicate that BMCs engraft, survive, and grow within the spared myocardium after infarction by forming junctional complexes with resident myocytes. BMCs and myocytes express at their interface connexin 43 and N-cadherin, and this interaction may be critical for BMCs to adopt the cardiomyogenic fate. With time, a large number of myocytes and coronary vessels are generated. Myocytes show a diploid DNA content and carry, at most, two sex chromosomes. Old and new myocytes show synchronicity in calcium transients, providing strong evidence in favor of the functional coupling of these two cell populations. Thus, BMCs transdifferentiate and acquire the cardiomyogenic and vascular phenotypes restoring the infarcted heart. Together, our studies reveal that locally delivered BMCs generate de novo myocardium composed of integrated cardiomyocytes and coronary vessels. This process occurs independently of cell fusion and ameliorates structurally and functionally the outcome of the heart after infarction.
313 citations
••
TL;DR: A global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends and a estimates of health-related SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous.
312 citations
••
TL;DR: The results suggest that a comprehensive assessment of a child's maltreatment experience, including type and severity, when the maltreatment began and the pattern of malt treatment across the life span, is important to understanding the effects of maltreatment on children's growth and development.
312 citations
••
TL;DR: Only grafts containing TH-expressing fibroblasts were found to reduce rotational asymmetry and have general implications for the application of gene therapy to human neurological disease and specific implications for Parkinson disease.
Abstract: Rat fibroblasts were infected with a retroviral vector containing the cDNA for rat tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2]. A TH-positive clone was identified by biochemical assay and immunohistochemical staining. When supplemented in vitro with pterin cofactors required for TH activity, these cells produced L-dopa and released it into the cell culture medium. Uninfected control cells and fibroblasts infected with the TH vector were grafted separately to the caudate of rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. Only grafts containing TH-expressing fibroblasts were found to reduce rotational asymmetry. These results have general implications for the application of gene therapy to human neurological disease and specific implications for Parkinson disease.
311 citations
••
TL;DR: The NEMS-R has evidence of reliability, can discriminate restaurant types, and can be used in research and practice to characterize restaurant environments.
311 citations
Authors
Showing all 12533 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
James F. Sallis | 169 | 825 | 144836 |
Steven Williams | 144 | 1375 | 86712 |
Larry R. Squire | 143 | 472 | 85306 |
Murray B. Stein | 128 | 745 | 89513 |
Robert Edwards | 121 | 775 | 74552 |
Roberto Kolter | 120 | 315 | 52942 |
Jack E. Dixon | 115 | 408 | 47201 |
Sonia Ancoli-Israel | 115 | 520 | 46045 |
John D. Lambris | 114 | 651 | 48203 |
Igor Grant | 113 | 791 | 55147 |
Kenneth H. Nealson | 108 | 483 | 51100 |
Mark Westoby | 108 | 316 | 59095 |
Eric Courchesne | 107 | 240 | 41200 |
Marc A. Schuckit | 106 | 643 | 43484 |