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Institution

San Diego State University

EducationSan Diego, California, United States
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.


Papers
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Journal ArticleDOI
TL;DR: Despite differences in content and in response formats, all 3 surveys showed evidence of reliability, and most items are now ready for use in research and in public health surveillance.
Abstract: Objectives. We tested the reliability of 3 instruments that assessed social and physical environments. Methods. We conducted a test–retest study among US adults (n = 289). We used telephone survey methods to measure suitableness of the perceived (vs objective) environment for recreational physical activity and nonmotorized transportation. Results. Most questions in our surveys that attempted to measure specific characteristics of the built environment showed moderate to high reliability. Questions about the social environment showed lower reliability than those that assessed the physical environment. Certain blocks of questions appeared to be selectively more reliable for urban or rural respondents. Conclusions. Despite differences in content and in response formats, all 3 surveys showed evidence of reliability, and most items are now ready for use in research and in public health surveillance.

311 citations

Journal ArticleDOI
TL;DR: In this article, the authors identify key practices for promoting physical activity in older adults, with a focus on those with chronic disease or low fitness and those with low levels of physical activity.
Abstract: Physical activity offers one of the greatest opportunities for people to extend years of active independent life and reduce functional limitations. The article identifies key practices for promoting physical activity in older adults, with a focus on those with chronic disease or low fitness and those with low levels of physical activity. Key practices identified: (a) A multidimensional activity program that includes endurance, strength, balance, and flexibility training is optimal for health and functional benefits; (b) principles of behavior change including social support, self-efficacy, active choices, health contracts, assurances of safety, and positive reinforcement enhance adherence; (c) manage risk by beginning at low intensity but gradually increasing to moderate physical activity, which has a better risk:benefit ratio and should be the goal for older adults; (d) an emergency procedure plan is prudent for community-based programs; and (e) monitoring aerobic intensity is important for progression and motivation. Selected content review of physical activity programming from major organizations and institutions is provided.

310 citations

Journal ArticleDOI
TL;DR: Results supported synergistic interactions between built environment and psychosocial factors in explaining physical activity among older adults and suggest multilevel interventions may be most effective in increasing physical activity.

310 citations

Journal ArticleDOI
TL;DR: The role of leadership and actions that leaders can take at and across levels in developing a strategic climate for EBP implementation within the outer and inner contexts of health care are addressed.
Abstract: There has been a growing impetus to bridge the gap between basic science discovery, development of evidence-based practices (EBPs), and the availability and delivery of EBPs in order to improve the public health impact of such practices. To capitalize on factors that support implementation and sustainment of EBPs, it is important to consider that health care is delivered within the outer context of public health systems and the inner context of health care organizations and work groups. Leaders play a key role in determining the nature of system and organizational contexts. This article addresses the role of leadership and actions that leaders can take at and across levels in developing a strategic climate for EBP implementation within the outer (i.e., system) and inner (i.e., organization, work group) contexts of health care. Within the framework of Edgar Schein's “climate embedding mechanisms,” we describe strategies that leaders at the system, organization, and work group levels can consider and apply ...

310 citations

Journal ArticleDOI
08 Jun 2011-PLOS ONE
TL;DR: It is found that depletion of p62 attenuated mitophagy and exacerbated cell death in HL-1 cardiomyocytes subjected to sI results reveal for the first time the crucial role of Parkin andMitophagy in cardioprotection.
Abstract: Autophagy-dependent mitochondrial turnover in response to cellular stress is necessary for maintaining cellular homeostasis. However, the mechanisms that govern the selective targeting of damaged mitochondria are poorly understood. Parkin, an E3 ubiquitin ligase, has been shown to be essential for the selective clearance of damaged mitochondria. Parkin is expressed in the heart, yet its function has not been investigated in the context of cardioprotection. We previously reported that autophagy is required for cardioprotection by ischemic preconditioning (IPC). In the present study, we used simulated ischemia (sI) in vitro and IPC of hearts to investigate the role of Parkin in mediating cardioprotection ex vivo and in vivo. In HL-1 cells, sI induced Parkin translocation to mitochondria and mitochondrial elimination. IPC induced Parkin translocation to mitochondria in Langendorff-perfused rat hearts and in vivo in mice subjected to regional IPC. Mitochondrial depolarization with an uncoupling agent similarly induced Parkin translocation to mitochondria in cells and Langendorff-perfused rat hearts. Mitochondrial loss was blunted in Atg5-deficient cells, revealing the requirement for autophagy in mitochondrial elimination. Consistent with previous reports indicating a role for p62/SQSTM1 in mitophagy, we found that depletion of p62 attenuated mitophagy and exacerbated cell death in HL-1 cardiomyocytes subjected to sI. While wild type mice showed p62 translocation to mitochondria and an increase in ubiquitination, Parkin knockout mice exhibited attenuated IPC-induced p62 translocation to the mitochondria. Importantly, ablation of Parkin in mice abolished the cardioprotective effects of IPC. These results reveal for the first time the crucial role of Parkin and mitophagy in cardioprotection.

310 citations


Authors

Showing all 12533 results

NameH-indexPapersCitations
David R. Williams1782034138789
James F. Sallis169825144836
Steven Williams144137586712
Larry R. Squire14347285306
Murray B. Stein12874589513
Robert Edwards12177574552
Roberto Kolter12031552942
Jack E. Dixon11540847201
Sonia Ancoli-Israel11552046045
John D. Lambris11465148203
Igor Grant11379155147
Kenneth H. Nealson10848351100
Mark Westoby10831659095
Eric Courchesne10724041200
Marc A. Schuckit10664343484
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202345
2022168
20211,595
20201,535
20191,454
20181,262