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Institution

San Diego State University

EducationSan Diego, California, United States
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.


Papers
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Journal ArticleDOI
TL;DR: A remodelling of the inner mitochondrial membrane into many separate vesicular matrix compartments that accompanies release of proteins is identified; however, this remodelling is not required for efficient release of cytochrome c.
Abstract: In addition to their role in cellular bioenergetics, mitochondria also initiate common forms of programmed cell death (apoptosis) through the release of proteins such as cytochrome c from the intermembrane and intracristal spaces. The release of these proteins is studied in populations of cells by western blotting mitochondrial and cytoplasmic fractions of cellular extracts, and in single cells by fluorescence microscopy using fluorescent indicators and fusion proteins. However, studying the changes in ultrastructure associated with release of proteins requires the higher resolution provided by transmission electron microscopy. Here, we have used fluorescence microscopy to characterize the state of apoptosis in HeLa cells treated with etoposide followed by electron microscopy and three-dimensional electron microscope tomography of the identical cells to study the sequence of structural changes. We have identified a remodelling of the inner mitochondrial membrane into many separate vesicular matrix compartments that accompanies release of proteins; however, this remodelling is not required for efficient release of cytochrome c. Swelling occurs only late in apoptosis after release of cytochrome c and loss of the mitochondrial membrane potential.

243 citations

Journal ArticleDOI
TL;DR: In this article, the discovery and characterization of the circumbinary planet Kepler-38b was discussed, and a photometric dynamical model fit to the radial velocity curve and Kepler light curve yields a planetary radius of 4.35 ± 0.053 days.
Abstract: We discuss the discovery and characterization of the circumbinary planet Kepler-38b. The stellar binary is single-lined, with a period of 18.8 days, and consists of a moderately evolved main-sequence star (M_A = 0.949 ± 0.059 M_☉ and R_A = 1.757 ± 0.034 R_☉) paired with a low-mass star (M_B = 0.249 ± 0.010 M_☉ and R_B = 0.2724 ± 0.0053 R_☉) in a mildly eccentric (e = 0.103) orbit. A total of eight transits due to a circumbinary planet crossing the primary star were identified in the Kepler light curve (using Kepler Quarters 1-11), from which a planetary period of 105.595 ± 0.053 days can be established. A photometric dynamical model fit to the radial velocity curve and Kepler light curve yields a planetary radius of 4.35 ± 0.11 R_⊕, or equivalently 1.12 ± 0.03 R_(Nep). Since the planet is not sufficiently massive to observably alter the orbit of the binary from Keplerian motion, we can only place an upper limit on the mass of the planet of 122 M_⊕ (7.11 M_(Nep) or equivalently 0.384 M_(Jup)) at 95% confidence. This upper limit should decrease as more Kepler data become available.

243 citations

Journal ArticleDOI
TL;DR: The most common influences that facilitate and hinder CAPs should guide their development and sustainment, which in turn should be reported more systematically to advance the field.
Abstract: Policy Points: Communities, funding agencies, and institutions are increasingly involving community stakeholders as partners in research, to provide firsthand knowledge and insight. Based on our systematic review of major literature databases, we recommend using a single term, community‐academic partnership (CAP), and a conceptual definition to unite multiple research disciplines and strengthen the field. Interpersonal and operational factors that facilitate or hinder the collaborative process have been consistently identified, including “trust among partners” and “respect among partners” (facilitating interpersonal factors) and “excessive time commitment” (hindering operational factor). Once CAP processes and characteristics are better understood, the effectiveness of collaborative partner involvement can be tested.

243 citations

Journal ArticleDOI
TL;DR: Cette etude a pour but de construire une mesure des pensees positives afin de completer le «Automatic Thoughts Questionnaire» ou seules, les pensee negatives sont evaluees.
Abstract: Cette etude a pour but de construire une mesure des pensees positives afin de completer le «Automatic Thoughts Questionnaire» ou seules, les pensees negatives sont evaluees. Cette nouvelle echelle revele utile et de bonne qualite psychometrique

243 citations

Book ChapterDOI
01 Jan 2002
TL;DR: For example, the authors found that clinicians find themselves in the predicament of prescribing what constitutes appropriate assessment for Asian American clients, and they find it difficult to explain the process by which they use cultural information to enhance interventions.
Abstract: Invariably, clinicians find themselves in the predicament of prescribing what constitutes appropriate assessment for Asian American clients. On the one hand, many culturally sensitive and culturally competent clinicians think and go about doing assessment in certain ways to account for and incorporate the cultural background and experiences of Asian American clients into the diagnostic, case conceptualization, and treatment planning processes. Sometimes certain procedural and stylistic changes are indicated while at other times completely different assessment strategies and approaches are necessary to achieve effective outcomes. We also know with a fair degree of confidence that such changes in the traditional Western therapy regimen have an ameliorative effect, which result in clinically significant improvements in treatment efficacy. On the other hand, when asked to describe the manner by which these clinicians come to select a particular strategy or to implement a certain procedure, we frequently experience difficulty in articulating this process. This difficulty cannot be solely attributed to language problems. American-born, primarily English-speaking Asian American therapists also may find it difficult to explain the process by which they account for and use cultural information to enhance interventions. Rather, the problem results more from the use of a Western-based “therapeutic language” that prevents us from expressing the cultural dynamics involved in a particular case.

243 citations


Authors

Showing all 12533 results

NameH-indexPapersCitations
David R. Williams1782034138789
James F. Sallis169825144836
Steven Williams144137586712
Larry R. Squire14347285306
Murray B. Stein12874589513
Robert Edwards12177574552
Roberto Kolter12031552942
Jack E. Dixon11540847201
Sonia Ancoli-Israel11552046045
John D. Lambris11465148203
Igor Grant11379155147
Kenneth H. Nealson10848351100
Mark Westoby10831659095
Eric Courchesne10724041200
Marc A. Schuckit10664343484
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202345
2022168
20211,595
20201,535
20191,454
20181,262