San Diego State University

About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.

Abstract: Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of antioxidants is ineffective, suggesting that our current understanding of the underlying regulatory processes is incomplete. Recent Advances: Similar to reactive oxygen species and reactive nitrogen species, reactive sulfur species are now emerging as important signaling molecules, targeting regulatory cysteine redox switches in proteins, affecting gene regulation, ion transport, intermediary metabolism, and mitochondrial function. To rationalize the complexity of chemical interactions of reactive species with themselves and their targets and help define their role in systemic metabolic control, we here introduce a novel integrative concept defined as the reactive species interactome (RSI). The RSI is a primeval multilevel redox regulatory system whose architecture, together with the physicochemical characteristics of its constitu...

Fault steps and the dynamic rupture process: 2-D numerical simulations of a spontaneously propagating shear fracture

Abstract: Fault steps may have controlled the sizes of the 1966 Parkfield, 1968 Borrego Mountain, 1979 Imperial Valley, 1979 Coyote Lake and the 1987 Superstition Hills earthquakes. This project investigates the effect of fault steps of various geometries on the dynamic rupture process. We have used a finite difference code to simulate spontaneous rupture propagation in two dimensions. We employ a slip-weakening fracture criterion as the condition for rupture propagation and examine how rupture on one plane initiates rupture on parallel fault planes. The geometry of the two parallel fault planes allows for stepover widths of 0.5 to 10.0 km and overlaps of −5 to 5 km. Our results demonstrate that the spontaneous rupture on the first fault segment continues to propagate onto the second fault segment for a range of geometries for both compressional and dilational fault steps. A major difference between the compressional and dilational cases is, that a dilational step requires a longer time delay between the rupture front reaching the end of the first fault segment and initiating rupture on the second segment. Therefore our dynamic study implies that a compressional step will be jumped quickly, whereas a dilational step will cause a time delay leading to a lower apparent rupture velocity. We also find that the rupture is capable of jumping a wider dilational step than compressional step.

The prevalence of post-traumatic stress disorder in the Vietnam generation : a multimethod, multisource assessment of psychiatric disorder

Abstract: Findings from the Congressionally mandated National Vietnam Veterans Readjustment Study indicate that nearly one-half million Vietnam veterans—15.2% of the men and 8.5% of the women who served in Vietnam—suffer from post-traumatic stress disorder (PTSD) fifteen or more years after their military service. Current PTSD prevalence rates for Vietnam veterans are significantly and substantially higher than the rates for their comparable Vietnam generation peers, which range from 0.3% to 2.5%. Additionally, the current prevalence rate among male Vietnam veterans was found to differ significantly among race/ethnicity subgroups: 27.9% among Hispanic men, 20.6% among black men, 13.7% among white/other men. Multivariate analyses indicated that although background factors are significantly related to the current prevalence of PTSD, the current prevalence is much higher among Vietnam veterans than among era veteran and civilian counterpart comparison groups even after background differences are taken into account. These analyses also demonstrated the important role of exposure to combat and other types of war zone stress in the current prevalence of the disorder.

Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

Abstract: This article is a summary of the activities of the ICTV's Bacterial and Archaeal Viruses Subcommittee for the years 2018 and 2019. Highlights include the creation of a new order, 10 families, 22 subfamilies, 424 genera and 964 species. Some of our concerns about the ICTV's ability to adjust to and incorporate new DNA- and protein-based taxonomic tools are discussed.