Institution
San Diego State University
Education•San Diego, California, United States•
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.
Topics: Population, Poison control, Health care, Mental health, Public health
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Ames Research Center1, University of California, Berkeley2, San Jose State University3, Las Cumbres Observatory Global Telescope Network4, Search for extraterrestrial intelligence5, York University6, Aarhus University7, University of Texas at Austin8, Lowell Observatory9, Harvard University10, California Institute of Technology11, Space Telescope Science Institute12, Lawrence Hall of Science13, Goddard Space Flight Center14, United States Department of the Navy15, Carnegie Institution for Science16, University of Washington17, University of Hawaii at Hilo18, University of California, Santa Cruz19, Massachusetts Institute of Technology20, Fermilab21, San Diego State University22, Southern Connecticut State University23, Planetary Science Institute24, Yale University25, Marshall Space Flight Center26, The Catholic University of America27, University of Idaho28, Villanova University29
TL;DR: The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars, which is the region where planetary temperatures are suitable for water to exist on a planet's surface.
Abstract: The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars. The habitable zone is the region where planetary temperatures are suitable for water to exist on a planet’s surface. During the first 6 weeks of observations, Kepler monitored 156,000 stars, and five new exoplanets with sizes between 0.37 and 1.6 Jupiter radii and orbital periods from 3.2 to 4.9 days were discovered. The density of the Neptune-sized Kepler-4b is similar to that of Neptune and GJ 436b, even though the irradiation level is 800,000 times higher. Kepler-7b is one of the lowest-density planets (~0.17 gram per cubic centimeter) yet detected. Kepler-5b, -6b, and -8b confirm the existence of planets with densities lower than those predicted for gas giant planets.
3,663 citations
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TL;DR: The interconnectedness of the SEED database and RAST, the RAST annotation pipeline and updates to both resources are described.
Abstract: In 2004, the SEED (http://pubseed.theseed.org/) was created to provide consistent and accurate genome annotations across thousands of genomes and as a platform for discovering and developing de novo annotations. The SEED is a constantly updated integration of genomic data with a genome database, web front end, API and server scripts. It is used by many scientists for predicting gene functions and discovering new pathways. In addition to being a powerful database for bioinformatics research, the SEED also houses subsystems (collections of functionally related protein families) and their derived FIGfams (protein families), which represent the core of the RAST annotation engine (http://rast.nmpdr.org/). When a new genome is submitted to RAST, genes are called and their annotations are made by comparison to the FIGfam collection. If the genome is made public, it is then housed within the SEED and its proteins populate the FIGfam collection. This annotation cycle has proven to be a robust and scalable solution to the problem of annotating the exponentially increasing number of genomes. To date, >12 000 users worldwide have annotated >60 000 distinct genomes using RAST. Here we describe the interconnectedness of the SEED database and RAST, the RAST annotation pipeline and updates to both resources.
3,415 citations
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TL;DR: The open-source metagenomics RAST service provides a new paradigm for the annotation and analysis of metagenomes that is stable, extensible, and freely available to all researchers.
Abstract: Random community genomes (metagenomes) are now commonly used to study microbes in different environments. Over the past few years, the major challenge associated with metagenomics shifted from generating to analyzing sequences. High-throughput, low-cost next-generation sequencing has provided access to metagenomics to a wide range of researchers. A high-throughput pipeline has been constructed to provide high-performance computing to all researchers interested in using metagenomics. The pipeline produces automated functional assignments of sequences in the metagenome by comparing both protein and nucleotide databases. Phylogenetic and functional summaries of the metagenomes are generated, and tools for comparative metagenomics are incorporated into the standard views. User access is controlled to ensure data privacy, but the collaborative environment underpinning the service provides a framework for sharing datasets between multiple users. In the metagenomics RAST, all users retain full control of their data, and everything is available for download in a variety of formats. The open-source metagenomics RAST service provides a new paradigm for the annotation and analysis of metagenomes. With built-in support for multiple data sources and a back end that houses abstract data types, the metagenomics RAST is stable, extensible, and freely available to all researchers. This service has removed one of the primary bottlenecks in metagenome sequence analysis – the availability of high-performance computing for annotating the data. http://metagenomics.nmpdr.org
3,322 citations
01 Jan 2008
3,298 citations
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TL;DR: New fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations are constructed and dubbed ‘cameleons’.
Abstract: Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard to measure. To overcome this problem we have constructed new fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations. We have dubbed these fluorescent indicators 'cameleons'. They consist of tandem fusions of a blue- or cyan-emitting mutant of the green fluorescent protein (GFP), calmodulin, the calmodulin-binding peptide M13, and an enhanced green- or yellow-emitting GFP. Binding of Ca2+ makes calmodulin wrap around the M13 domain, increasing the fluorescence resonance energy transfer (FRET) between the flanking GFPs. Calmodulin mutations can tune the Ca2+ affinities to measure free Ca2+ concentrations in the range 10(-8) to 10(-2) M. We have visualized free Ca2+ dynamics in the cytosol, nucleus and endoplasmic reticulum of single HeLa cells transfected with complementary DNAs encoding chimaeras bearing appropriate localization signals. Ca2+ concentration in the endoplasmic reticulum of individual cells ranged from 60 to 400 microM at rest, and 1 to 50 microM after Ca2+ mobilization. FRET is also an indicator of the reversible intermolecular association of cyan-GFP-labelled calmodulin with yellow-GFP-labelled M13. Thus FRET between GFP mutants can monitor localized Ca2+ signals and protein heterodimerization in individual live cells.
3,248 citations
Authors
Showing all 12533 results
Name | H-index | Papers | Citations |
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David R. Williams | 178 | 2034 | 138789 |
James F. Sallis | 169 | 825 | 144836 |
Steven Williams | 144 | 1375 | 86712 |
Larry R. Squire | 143 | 472 | 85306 |
Murray B. Stein | 128 | 745 | 89513 |
Robert Edwards | 121 | 775 | 74552 |
Roberto Kolter | 120 | 315 | 52942 |
Jack E. Dixon | 115 | 408 | 47201 |
Sonia Ancoli-Israel | 115 | 520 | 46045 |
John D. Lambris | 114 | 651 | 48203 |
Igor Grant | 113 | 791 | 55147 |
Kenneth H. Nealson | 108 | 483 | 51100 |
Mark Westoby | 108 | 316 | 59095 |
Eric Courchesne | 107 | 240 | 41200 |
Marc A. Schuckit | 106 | 643 | 43484 |