Institution
San Diego State University
Education•San Diego, California, United States•
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.
Topics: Population, Poison control, Health care, Mental health, Public health
Papers published on a yearly basis
Papers
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TL;DR: These marine cyanophages appear to be variations of two well-known phages—T7 and T4—but contain genes that, if functional, reflect adaptations for infection of photosynthetic hosts in low-nutrient oceanic environments.
Abstract: The oceanic cyanobacteria Prochlorococcus are globally important, ecologically diverse primary producers. It is thought that their viruses (phages) mediate population sizes and affect the evolutionary trajectories of their hosts. Here we present an analysis of genomes from three Prochlorococcus phages: a podovirus and two myoviruses. The morphology, overall genome features, and gene content of these phages suggest that they are quite similar to T7-like (P-SSP7) and T4-like (P-SSM2 and P-SSM4) phages. Using the existing phage taxonomic framework as a guideline, we examined genome sequences to establish “core” genes for each phage group. We found the podovirus contained 15 of 26 core T7-like genes and the two myoviruses contained 43 and 42 of 75 core T4-like genes. In addition to these core genes, each genome contains a significant number of “cyanobacterial” genes, i.e., genes with significant best BLAST hits to genes found in cyanobacteria. Some of these, we speculate, represent “signature” cyanophage genes. For example, all three phage genomes contain photosynthetic genes (psbA, hliP) that are thought to help maintain host photosynthetic activity during infection, as well as an aldolase family gene (talC) that could facilitate alternative routes of carbon metabolism during infection. The podovirus genome also contains an integrase gene (int) and other features that suggest it is capable of integrating into its host. If indeed it is, this would be unprecedented among cultured T7-like phages or marine cyanophages and would have significant evolutionary and ecological implications for phage and host. Further, both myoviruses contain phosphate-inducible genes (phoH and pstS) that are likely to be important for phage and host responses to phosphate stress, a commonly limiting nutrient in marine systems. Thus, these marine cyanophages appear to be variations of two well-known phages—T7 and T4—but contain genes that, if functional, reflect adaptations for infection of photosynthetic hosts in low-nutrient oceanic environments.
520 citations
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TL;DR: The potential of metagenomics for characterization of the normal viral population in a healthy community and identification of viruses that could pose a threat to humans through zoonosis is discussed and a new model of the Koch's postulates named the ‘Metagenomic Koch's Postulates’ is proposed.
518 citations
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TL;DR: In this paper, the authors present the longest and most detailed records of habitat development at a mitigation site: data on soil organic matter, soil nitrogen, plant growth, and plant canopies for up to 10 years from a 12-year old site.
Abstract: Hypothetical models in the scientific literature suggest that ecosystem restoration and creation sites follow a smooth path of development (called a trajectory), rapidly matching natural reference sites (the target). Multi-million-dollar mitigation agreements have been based on the expectation that damages to habitat will be compensated within 5‐10 years, and monitoring periods have been set accordingly. Our San Diego Bay study site, the Sweetwater Marsh National Wildlife Refuge, has one of the longest and most detailed records of habitat development at a mitigation site: data on soil organic matter, soil nitrogen, plant growth, and plant canopies for up to 10 years from a 12-year-old site. High interannual variation and lack of directional changes indicate little chance that targets will be reached in the near future. Other papers perpetuate the trajectory model, despite data that corroborate our findings. After reviewing “trajectory models” and presenting our comprehensive data for the first time, we suggest alternative management and mitigation policies.
518 citations
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University of British Columbia1, Imperial College London2, University of Basel3, University of Bristol4, University of Southern California5, Utrecht University6, Flemish Institute for Technological Research7, University of California, Berkeley8, University of Canterbury9, West Virginia University10, National University of Ireland, Galway11, University of Minnesota12, Mines ParisTech13, University of North Carolina at Chapel Hill14, University of Chile15, San Diego State University16, Netherlands Organisation for Applied Scientific Research17, National Institute for Health and Welfare18
TL;DR: Evaluating impacts of active travel policies is highly complex; however, many associations can be quantified, and identifying health-maximizing policies and conditions requires integrated HIAs.
517 citations
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TL;DR: For example, this paper derived month-by-month norms for comprehension and production of 396 words from 8 to 16 months and 680 words from 16 to 30 months from a norming study of 1,789 children between the ages of 8 and 30 months using the MacArthur Communicative Development Inventories (Fenson et al., 1993).
Abstract: Developmental norms for young children’s vocabularies have a number of applications in research design, assessment, and intervention, but have previously been very difficult to obtain. In the present study, month-by-month norms for comprehension and production of 396 words from 8 to 16 months, and production of 680 words from 16 to 30 months, were derived from a norming study of 1,789 children between the ages of 8 and 30 months using the MacArthur Communicative Development Inventories (Fenson et al., 1993). The norms are available in the form of a database program, LEX, for MS-DOS-based computers.
516 citations
Authors
Showing all 12533 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
James F. Sallis | 169 | 825 | 144836 |
Steven Williams | 144 | 1375 | 86712 |
Larry R. Squire | 143 | 472 | 85306 |
Murray B. Stein | 128 | 745 | 89513 |
Robert Edwards | 121 | 775 | 74552 |
Roberto Kolter | 120 | 315 | 52942 |
Jack E. Dixon | 115 | 408 | 47201 |
Sonia Ancoli-Israel | 115 | 520 | 46045 |
John D. Lambris | 114 | 651 | 48203 |
Igor Grant | 113 | 791 | 55147 |
Kenneth H. Nealson | 108 | 483 | 51100 |
Mark Westoby | 108 | 316 | 59095 |
Eric Courchesne | 107 | 240 | 41200 |
Marc A. Schuckit | 106 | 643 | 43484 |