Institution
San Francisco General Hospital
Healthcare•San Francisco, California, United States•
About: San Francisco General Hospital is a healthcare organization based out in San Francisco, California, United States. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 2929 authors who have published 3517 publications receiving 185383 citations. The organization is also known as: Zuckerberg San Francisco General Hospital and Trauma Center & SFGH.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), Health care, Poison control, Medicine
Papers published on a yearly basis
Papers
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Veterans Health Administration1, University of Miami2, San Francisco General Hospital3, University of California, San Francisco4, University of Missouri5, University of California, Los Angeles6, Tufts University7, University of Washington8, University of Minnesota9, Stanford University10, Palo Alto Medical Foundation11, VA Palo Alto Healthcare System12, Medical College of Wisconsin13
TL;DR: It is the recommendation of this committee that patients with soft-tissue infection be distinguished by signs and symptoms of systemic toxicity (e.g., fever or hypothermia, tachycardia [heart rate,] and so on).
Abstract: EXECUTIVE SUMMARYSoft-tissue infections are common, generally of mild tomodest severity, and are easily treated with a variety ofagents. An etiologic diagnosis of simple cellulitis is fre-quently difficult and generally unnecessary for patientswith mild signs and symptoms of illness. Clinical as-sessment of the severity of infection is crucial, and sev-eral classification schemes and algorithms have beenproposed to guide the clinician [1]. However, mostclinical assessments have been developed from eitherretrospective studies or from an author’s own “clinicalexperience,” illustrating the need for prospectivestudieswith defined measurements of severity coupled to man-agement issues and outcomes.Until then, it is the recommendation of this com-mittee that patients with soft-tissue infection accom-panied by signs and symptoms of systemic toxicity (e.g.,fever or hypothermia, tachycardia [heart rate,
2,008 citations
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TL;DR: This guideline addresses the wide array of SSTIs that occur in this population and emphasizes the importance of clinical skills in promptly diagnosing SSTI, identifying the pathogen, and administering effective treatments in a timely fashion.
Abstract: A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections. The focus of this guideline is the diagnosis and appropriate treatment of diverse SSTIs ranging from minor superficial infections to life-threatening infections such as necrotizing fasciitis. In addition, because of an increasing number of immunocompromised hosts worldwide, the guideline addresses the wide array of SSTIs that occur in this population. These guidelines emphasize the importance of clinical skills in promptly diagnosing SSTIs, identifying the pathogen, and administering effective treatments in a timely fashion.
1,856 citations
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TL;DR: Among patients with a recent myocardial infarction, colchicine at a dose of 0.5 mg daily led to a significantly lower risk of ischemic cardiovascular events than placebo.
Abstract: Background Experimental and clinical evidence supports the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medi...
1,426 citations
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TL;DR: HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts and is present in choriocarcinoma cell lines studied.
Abstract: The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.
1,373 citations
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TL;DR: Findings support the role of SMO as a signalling component of the SHH–receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs.
Abstract: Basal-cell carcinomas (BCCs) are the commonest human cancer. Insight into their genesis came from identification of mutations in the PATCHED gene (PTCH) in patients with the basal-cell nevus syndrome, a hereditary disease characterized by multiple BCCs and by developmental abnormalities. The binding of Sonic hedgehog (SHH) to its receptor, PTCH, is thought to prevent normal inhibition by PTCH of Smoothened (SMO), a seven-span transmembrane protein. According to this model, the inhibition of SMO signalling is relieved following mutational inactivation of PTCH in basal-cell nevus syndrome. We report here the identification of activating somatic missense mutations in the SMO gene itself in sporadic BCCs from three patients. Mutant SMO, unlike wild type, can cooperate with adenovirus E1A to transform rat embryonic fibroblast cells in culture. Furthermore, skin abnormalities similar to BCCs developed in transgenic murine skin overexpressing mutant SMO. These findings support the role of SMO as a signalling component of the SHH-receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs.
1,328 citations
Authors
Showing all 2952 results
Name | H-index | Papers | Citations |
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Caroline S. Fox | 155 | 599 | 138951 |
Michael A. Matthay | 151 | 998 | 98687 |
Rajesh Kumar | 149 | 4439 | 140830 |
Richard J. Johnson | 137 | 880 | 72201 |
Steven G. Deeks | 131 | 647 | 61634 |
Jennifer S. Haas | 128 | 840 | 71315 |
Robert W. Mahley | 128 | 363 | 60774 |
Peter M. Elias | 127 | 581 | 49825 |
Scott L. Friedman | 126 | 488 | 62931 |
Neal L. Benowitz | 126 | 792 | 60658 |
Eric Vittinghoff | 122 | 784 | 66032 |
Kamyar Kalantar-Zadeh | 118 | 1025 | 56187 |
Thomas J. Ryan | 116 | 675 | 67462 |
Hedvig Hricak | 116 | 689 | 44055 |
Robert V. Farese | 115 | 473 | 48754 |