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Showing papers by "San Francisco State University published in 2014"


Journal ArticleDOI
09 Jan 2014-Nature
TL;DR: The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.
Abstract: The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and immunoglobulin-based adaptive immunity. Gnathostomes subsequently diverged into two groups, the cartilaginous fishes and the bony vertebrates. Here we report the whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii). We find that the C. milii genome is the slowest evolving of all known vertebrates, including the ‘living fossil’ coelacanth, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes. Our functional studies suggest that the lack of genes encoding secreted calcium-binding phosphoproteins in cartilaginous fishes explains the absence of bone in their endoskeleton. Furthermore, the adaptive immune system of cartilaginous fishes is unusual: it lacks the canonical CD4 co-receptor and most transcription factors, cytokines and cytokine receptors related to the CD4 lineage, despite the presence of polymorphic major histocompatibility complex class II molecules. It thus presents a new model for understanding the origin of adaptive immunity. Whole-genome analysis of the elephant shark, a cartilaginous fish, shows that it is the slowest evolving of all known vertebrates, lacks critical bone formation genes and has an unusual adaptive immune system. The elephant shark (Callorhinchus milii) is a cartilaginous fish native to the temperate waters off southern Australia and New Zealand, living at depths of 200 to 500 metres and migrating into shallow waters during spring for breeding. The genome sequence is published in this issue of Nature. Comparison with other vertebrate genomes shows that it is the slowest evolving genome of all known vertebrates — coelacanth included. Genome analysis points to an unusual adaptive immune system lacking the CD4 receptor and some associated cytokines, indicating that cartilaginous fishes possess a primordial gnathostome adaptive immune system. Also absent are genes encoding secreted calcium-binding phosphoproteins, in line with the absence of bone in cartilaginous fish.

616 citations


Journal ArticleDOI
TL;DR: In this article, a new UV-initiative HST project (GO-13297) was proposed to complement the existing F606W and F814W database of the ACS Globular Cluster (GC) Treasury by imaging most of its clusters through UV/blue WFC3/UVIS filters.
Abstract: In this paper we describe a new UV-initiative HST project (GO-13297) that will complement the existing F606W and F814W database of the ACS Globular Cluster (GC) Treasury by imaging most of its clusters through UV/blue WFC3/UVIS filters F275W, F336W and F438W This "magic trio" of filters has shown an uncanny ability to disentangle and characterize multiple-population (MP) patterns in GCs in a way that is exquisitely sensitive to C, N, and O abundance variations Combination of these passbands with those in the optical also gives the best leverage for measuring helium enrichment The dozen clusters that had previously been observed in these bands exhibit a bewildering variety of MP patterns, and the new survey will map the full variance of the phenomenon The ubiquity of multiple stellar generations in GCs has made the formation of these cornerstone objects more intriguing than ever; GC formation and the origin of their MPs have now become one and the same problem In the present paper we will describe the data base and our data reduction strategy, as well as the uses we intend to make of the final photometry, astrometry, and proper motions We will also present preliminary color-magnitude diagrams from the data so far collected These diagrams also draw on data from GO-12605 and GO-12311, which served as a pilot project for the present GO-13297

493 citations


Journal ArticleDOI
TL;DR: Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential inOedema, cancer, obesity, brain injury, glaucoma and several other conditions.
Abstract: The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators.

448 citations


Journal ArticleDOI
TL;DR: In this paper, a review examines climate change effects on groundwater and dependent ecosystems, focusing on the impacts of changes to groundwater on GDE biodiversity and future threats posed by climate change.

419 citations


Journal ArticleDOI
TL;DR: A review of the most current avenues of research into Kinect-based elderly care and stroke rehabilitation systems to provide an overview of the state of the art, limitations, and issues of concern as well as suggestions for future work in this direction is presented.
Abstract: In this paper we present a review of the most current avenues of research into Kinect-based elderly care and stroke rehabilitation systems to provide an overview of the state of the art, limitations, and issues of concern as well as suggestions for future work in this direction. The central purpose of this review was to collect all relevant study information into one place in order to support and guide current research as well as inform researchers planning to embark on similar studies or applications. The paper is structured into three main sections, each one presenting a review of the literature for a specific topic. Elderly Care section is comprised of two subsections: Fall detection and Fall risk reduction. Stroke Rehabilitation section contains studies grouped under Evaluation of Kinect’s spatial accuracy, and Kinect-based rehabilitation methods. The third section, Serious and exercise games, contains studies that are indirectly related to the first two sections and present a complete system for elderly care or stroke rehabilitation in a Kinect-based game format. Each of the three main sections conclude with a discussion of limitations of Kinect in its respective applications. The paper concludes with overall remarks regarding use of Kinect in elderly care and stroke rehabilitation applications and suggestions for future work. A concise summary with significant findings and subject demographics (when applicable) of each study included in the review is also provided in table format.

380 citations


Journal ArticleDOI
TL;DR: Two key approaches are focused on: measuring standing genetic variation within populations and experimental evolution, which highlight benefits and challenges of each approach and recommend future research directions for understanding the modulating role of evolution in a changing ocean.
Abstract: Ocean acidification poses a global threat to biodiversity, yet species might have the capacity to adapt through evolutionary change. Here we summarize tools available to determine species' capacity for evolutionary adaptation to future ocean change and review the progress made to date with respect to ocean acidification. We focus on two key approaches: measuring standing genetic variation within populations and experimental evolution. We highlight benefits and challenges of each approach and recommend future research directions for understanding the modulating role of evolution in a changing ocean.

343 citations


Journal ArticleDOI
TL;DR: A new type of edge state is found: one residing on the bearded edge that has never been predicted or observed in graphene, and can be classified as a Tamm-like state lacking any surface defect.
Abstract: The propagation of light in photonic crystals with a honeycomb structure mirrors the behaviour of charges in graphene, therefore allowing for the investigation of electronic properties that cannot otherwise be accessed in graphene itself. This approach is now used to predict unexpected edge states that localize in the bearded edges of hexagonal lattices.

305 citations


Journal ArticleDOI
18 Apr 2014-Science
TL;DR: The detection of Kepler-186f, a 1.11 ± 0.14 Earth-radius planet that is the outermost of five planets, all roughly Earth-sized, that transit a 0.47 ±0.05 solar-radius star, implying that if Kepler- 186f has an Earth-like atmosphere and water at its surface, then some of this water is likely to be in liquid form.
Abstract: The quest for Earth-like planets is a major focus of current exoplanet research. Although planets that are Earth-sized and smaller have been detected, these planets reside in orbits that are too close to their host star to allow liquid water on their surfaces. We present the detection of Kepler-186f, a 1.11 ± 0.14 Earth-radius planet that is the outermost of five planets, all roughly Earth-sized, that transit a 0.47 ± 0.05 solar-radius star. The intensity and spectrum of the star’s radiation place Kepler-186f in the stellar habitable zone, implying that if Kepler-186f has an Earth-like atmosphere and water at its surface, then some of this water is likely to be in liquid form.

287 citations


Journal ArticleDOI
TL;DR: This paper explores self-efficacy, sense of belonging, and science identity, as well as emerging assessment tools to monitor these dimensions of students' learning.
Abstract: While emphasis is often placed on assessing students' conceptual knowledge, less has been placed on investigating affective aspects of student biology learning. In this paper, we explore self-efficacy, sense of belonging, and science identity, as well as emerging assessment tools to monitor these dimensions of students' learning.

242 citations


Journal ArticleDOI
TL;DR: In this article, the authors compile spectroscopic abundance data from 84 literature sources for 50 elements across 3058 stars in the solar neighborhood, within 150 pc of the Sun, to produce the Hypatia catalog.
Abstract: We compile spectroscopic abundance data from 84 literature sources for 50 elements across 3058 stars in the solar neighborhood, within 150 pc of the Sun, to produce the Hypatia Catalog. We evaluate the variability of the spread in abundance measurements reported for the same star by different surveys. We also explore the likely association of the star within the Galactic disk, the corresponding observation and abundance determination methods for all catalogs in Hypatia, the influence of specific catalogs on the overall abundance trends, and the effect of normalizing all abundances to the same solar scale. The resulting stellar abundance determinations in the Hypatia Catalog are analyzed only for thin-disk stars with observations that are consistent between literature sources. As a result of our large data set, we find that the stars in the solar neighborhood may reveal an asymmetric abundance distribution, such that a [Fe/H]-rich group near the midplane is deficient in Mg, Si, S, Ca, Sc II, Cr II, and Ni as compared to stars farther from the plane. The Hypatia Catalog has a wide number of applications, including exoplanet hosts, thick- and thin-disk stars, and stars with different kinematic properties.

214 citations


Journal ArticleDOI
TL;DR: A review of the existing literature suggests that bilingual advantages (or disadvantages) may reflect task-specific differences that are unlikely to generalize to important general differences in EF and assumed measures of executive functioning may also be threatened by a lack of discriminant validity.
Abstract: A sample of 58 bilingual and 62 monolingual university students completed four tasks commonly used to test for bilingual advantages in executive functioning (EF): antisaccade, flanker, Simon, and color-shape switching. Across the four tasks, 13 different indices were derived that are assumed to reflect individual differences in inhibitory control, monitoring, or switching. The effects of bilingualism on the 13 measures were explored by directly comparing the means of the two language groups and through regression analyses using a continuous measure of bilingualism and multiple demographic characteristics as predictors. Across the 13 different measures and two types of data analysis there were very few significant results and those that did occur supported a monolingual advantage. An equally important goal was to assess the convergent validity through cross-task correlations of indices assume to measure the same component of executive functioning. Most of the correlations using difference-score measures were nonsignificant and many near zero. Although modestly higher levels of convergent validity are sometimes reported, a review of the existing literature suggests that bilingual advantages (or disadvantages) may reflect task-specific differences that are unlikely to generalize to important general differences in EF. Finally, as cautioned by Salthouse, assumed measures of executive functioning may also be threatened by a lack of divergent validity that separates individual or group differences in EF from those in general fluid intelligence or simple processing speed.

Journal ArticleDOI
Lawrence N. Hudson1, Tim Newbold2, Tim Newbold3, Sara Contu1  +270 moreInstitutions (167)
TL;DR: A new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world is described and assessed.
Abstract: Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species Existing global databases of species’ threat status or population time series are dominated by charismatic species The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines We describe and assess a new database of more than 16 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – wwwpredictsorguk) We make site-level summary data available alongside this article The full database will be publicly available in 2015

Journal ArticleDOI
TL;DR: In this paper, the authors presented the first study of high-precision internal proper motions (PMs) in a large sample of globular clusters, based on Hubble Space Telescope (HST) data obtained over the past decade with the ACS/WFC, ACS/HRC, and WFC3/UVIS instruments.
Abstract: We present the first study of high-precision internal proper motions (PMs) in a large sample of globular clusters, based on Hubble Space Telescope (HST) data obtained over the past decade with the ACS/WFC, ACS/HRC, and WFC3/UVIS instruments. We determine PMs for over 1.3 million stars in the central regions of 22 clusters, with a median number of ∼60,000 stars per cluster. These PMs have the potential to significantly advance our understanding of the internal kinematics of globular clusters by extending past line-of-sight (LOS) velocity measurements to two- or three-dimensional velocities, lower stellar masses, and larger sample sizes. We describe the reduction pipeline that we developed to derive homogeneous PMs from the very heterogeneous archival data. We demonstrate the quality of the measurements through extensive Monte Carlo simulations. We also discuss the PM errors introduced by various systematic effects and the techniques that we have developed to correct or remove them to the extent possible. We provide in electronic form the catalog for NGC 7078 (M 15), which consists of 77,837 stars in the central 2.'4. We validate the catalog by comparison with existing PM measurements and LOS velocities and use it to study the dependence of the velocity dispersion on radius,more » stellar magnitude (or mass) along the main sequence, and direction in the plane of the sky (radial or tangential). Subsequent papers in this series will explore a range of applications in globular-cluster science and will also present the PM catalogs for the other sample clusters.« less

Journal ArticleDOI
TL;DR: In this article, the authors found that people who are more connected with nature report more subjective well-being, and that the positive relation between connectedness with nature and psychological wellbeing would only be significant for those who tend to engage in nature's beauty (i.e., experience positive emotional responses when witnessing nature's beautiful).

Journal ArticleDOI
TL;DR: In this paper, the authors examined a sample of 168 bilinguals and 216 monolinguals and explored for differences based on: (1) the age of acquiring a second language (L2), (2) the relative proficiency of an L2 and (3) the number of languages used.
Abstract: Paap and Greenberg concluded that there is no coherent evidence for bilingual advantages in executive processing. More optimistic researchers believe that the advantages may be restricted to certain types of bilinguals. Recent large-scale and lifespan investigations that tested highly fluent bilinguals from communities where the same two languages are spoken by most residents reported no bilingual advantages in any age group or in any of the tasks used to measure executive functioning. The present study takes a complementary approach by examining a sample that is quite homogeneous in terms of current life experiences, but heterogeneous in terms of its exposure to second languages. The composite database of 168 bilinguals and 216 monolinguals is used to explore for differences based on: (1) the age of acquiring a second language (L2), (2) the relative proficiency of an L2 and (3) the number of languages used. Across 12 different measures of executive function, derived from 4 different nonverbal tasks, ther...

Journal ArticleDOI
TL;DR: In this article, two populations of an inbred ant that diverge in phenotype were sequenced to determine how variability is generated and reveal a tripartite interplay between transposable elements, life history and adaptation in an invasive species.
Abstract: Adaptation requires genetic variation, but founder populations are generally genetically depleted. Here we sequence two populations of an inbred ant that diverge in phenotype to determine how variability is generated. Cardiocondyla obscurior has the smallest of the sequenced ant genomes and its structure suggests a fundamental role of transposable elements (TEs) in adaptive evolution. Accumulations of TEs (TE islands) comprising 7.18% of the genome evolve faster than other regions with regard to single-nucleotide variants, gene/exon duplications and deletions and gene homology. A non-random distribution of gene families, larvae/adult specific gene expression and signs of differential methylation in TE islands indicate intragenomic differences in regulation, evolutionary rates and coalescent effective population size. Our study reveals a tripartite interplay between TEs, life history and adaptation in an invasive species.

Journal ArticleDOI
TL;DR: In this article, the authors examine the process through which ventures scale their social impact in base-of-the-pyramid communities, and find that the relationship between minimum critical specifications and social impact is mediated by contrasting approaches to resource mobilization, operating routines, and entrepreneurial adjustment.
Abstract: This paper examines the process through which ventures scale their social impact in base-of-the-pyramid communities. A careful review of extant literature reveals two distinct modes of scaling social impact – breadth and depth scale. Drawing on a longitudinal study of Naandi and Drishtee – two exemplary social ventures in rural India – it is suggested that the depth and breadth scale develop through different processes. Each venture dynamically balances a minimum critical specification of social innovation, affordability, and market penetration while scaling social impact. We chart this path to scale in the two social ventures, and find that the relationship between minimum critical specifications and social impact is mediated by contrasting approaches to resource mobilization, operating routines, and entrepreneurial adjustment. The findings suggest that the process of scaling social impact can be characterized by a punctuated equilibrium model of system change.

Journal ArticleDOI
TL;DR: There is limited data providing conclusive evidence for a comprehensible categorization of cell phone addiction, as well as a unified explanatory model specific to problematic mobile phone use.
Abstract: Background and aims Likening mobile phone use dependency to the classification of excessive behaviors may be necessarily equivalent in seriousness to previously established addictions such as problematic computing or excessive gambling. The aim of the study explores into the behavior of excessive use of mobile phones as a pathological behavior. Methods Two studies investigated criteria for problematic mobile phone usage by examining student (Study 1, N = 301) and nonstudent (Study 2, N = 362) responses to a set of adapted mobile phone addiction inventories. Study 1 investigated cell phone addiction inventories as constructs designed to measure problematic cell phone use. Additionally, Study 2 sought to predict age, depression, extraversion, emotional stability, impulse control, and self-esteem as independent variables that augment respondents' perceptions of problematic use. Results The results from Study 1 and Study 2 indicate that 10 to 25% of the participants tested exhibited problematic cell ...

Journal ArticleDOI
TL;DR: The physical role of nonperturbative saddle points of path integrals in theories without instantons are explained, using the example of the asymptotically free two-dimensional principal chiral model (PCM), and a quantum interpretation of previously discovered "uniton" unstable classical solutions is suggested.
Abstract: We explain the physical role of nonperturbative saddle points of path integrals in theories without instantons, using the example of the asymptotically free two-dimensional principal chiral model (PCM). Standard topological arguments based on homotopy considerations suggest no role for nonperturbative saddles in such theories. However, the resurgence theory, which unifies perturbative and nonperturbative physics, predicts the existence of several types of nonperturbative saddles associated with features of the large-order structure of the perturbation theory. These points are illustrated in the PCM, where we find new nonperturbative ``fracton'' saddle point field configurations, and suggest a quantum interpretation of previously discovered ``uniton'' unstable classical solutions. The fractons lead to a semiclassical realization of IR renormalons in the circle-compactified theory and yield the microscopic mechanism of the mass gap of the PCM.

Journal ArticleDOI
TL;DR: In this article, a conceptual framework for the integrated design of a food packaging and distribution network is proposed, which supports application to different food manufacturing and distribution supply chains, and considers fresh fruit and vegetable flow throughout a food catering chain from vendors to final customers.

Journal ArticleDOI
13 Feb 2014-PLOS ONE
TL;DR: Elevation predictions using the Marsh Equilibrium Model highlight the importance of including vegetation responses to sea-level rise and include adjacent uplands for long-term marsh survival and incorporating such areas in conservation planning efforts.
Abstract: Tidal marshes maintain elevation relative to sea level through accumulation of mineral and organic matter, yet this dynamic accumulation feedback mechanism has not been modeled widely in the context of accelerated sea-level rise. Uncertainties exist about tidal marsh resiliency to accelerated sea-level rise, reduced sediment supply, reduced plant productivity under increased inundation, and limited upland habitat for marsh migration. We examined marsh resiliency under these uncertainties using the Marsh Equilibrium Model, a mechanistic, elevation-based soil cohort model, using a rich data set of plant productivity and physical properties from sites across the estuarine salinity gradient. Four tidal marshes were chosen along this gradient: two islands and two with adjacent uplands. Varying century sea-level rise (52, 100, 165, 180 cm) and suspended sediment concentrations (100%, 50%, and 25% of current concentrations), we simulated marsh accretion across vegetated elevations for 100 years, applying the results to high spatial resolution digital elevation models to quantify potential changes in marsh distributions. At low rates of sea-level rise and mid-high sediment concentrations, all marshes maintained vegetated elevations indicative of mid/high marsh habitat. With century sea-level rise at 100 and 165 cm, marshes shifted to low marsh elevations; mid/high marsh elevations were found only in former uplands. At the highest century sea-level rise and lowest sediment concentrations, the island marshes became dominated by mudflat elevations. Under the same sediment concentrations, low salinity brackish marshes containing highly productive vegetation had slower elevation loss compared to more saline sites with lower productivity. A similar trend was documented when comparing against a marsh accretion model that did not model vegetation feedbacks. Elevation predictions using the Marsh Equilibrium Model highlight the importance of including vegetation responses to sea-level rise. These results also emphasize the importance of adjacent uplands for long-term marsh survival and incorporating such areas in conservation planning efforts.

Journal ArticleDOI
TL;DR: In this paper, the authors used near-infrared interferometric data coupled with trigonometric parallax values and spectral energy distribution fitting to directly determine stellar radii, effective temperatures and luminosities for the exoplanet host stars 61 Vir, ρ CrB, GJ 176 and GJ 614.
Abstract: We use near-infrared interferometric data coupled with trigonometric parallax values and spectral energy distribution fitting to directly determine stellar radii, effective temperatures and luminosities for the exoplanet host stars 61 Vir, ρ CrB, GJ 176, GJ 614, GJ 649, GJ 876, HD 1461, HD 7924, HD 33564, HD 107383 and HD 210702. Three of these targets are M dwarfs. Statistical uncertainties in the stellar radii and effective temperatures range from 0.5 to 5 per cent and from 0.2 to 2 per cent, respectively. For eight of these targets, this work presents the first directly determined values of radius and temperature; for the other three, we provide updates to their properties. The stellar fundamental parameters are used to estimate stellar mass and calculate the location and extent of each system’s circumstellar habitable zone. Two of these systems have planets that spend at least parts of their respective orbits in the system habitable zone: two of GJ 876’s four planets and the planet that orbits HD 33564. We find that our value for GJ 876’s stellar radius is more than 20 per cent larger than previous estimates and frequently used values in the astronomical literature.

Journal ArticleDOI
TL;DR: In this article, it was shown that the full nonperturbative expression for energy eigenvalues, containing all orders of perturbative, nonperturative, and quasi-zero-mode terms, may be generated directly from the perturbation expansion about the perturberative vacuum, combined with a single global boundary condition.
Abstract: In a large variety of quantum mechanical systems, we show that the full nonperturbative expression for energy eigenvalues, containing all orders of perturbative, nonperturbative, and quasi-zero-mode terms, may be generated directly from the perturbative expansion about the perturbative vacuum, combined with a single global boundary condition. This provides a dramatic realization of the principle of “resurgence,” that the fluctuations about different semiclassical saddle points are related to one another in a precise quantitative manner. The analysis of quantum mechanics also generalizes to certain calculable regimes of quantum field theory.

Journal ArticleDOI
TL;DR: The authors examined the role of reputation on decision-making under ambiguity and found that a firm's reputation increased its aspirations for future performance and promoted its engagement in risky strategies to achieve them, while preserving the already established reputation requires a firm to deliver consistent performance over time, which promotes greater use of risk reduction strategies.
Abstract: This study examines the role of reputation on decision making under ambiguity. Drawing on social cognition and behavioral theories, we propose that a firm's reputation exerts dual pressures on its decision making under ambiguity. On the one hand, a firm's reputation increases its aspirations for future performance and promotes its engagement in risky strategies to achieve them. On the other hand, preserving the already established reputation requires a firm to deliver consistent performance over time, which promotes greater use of risk reduction strategies. Our analyses of the U.S. venture capital firms' investments in the clean energy sector from 1990 to 2008 demonstrate that while reputable firms are more likely to invest in the emerging sector, they also employ risk reduction strategies more extensively. The sector's legitimation further influences these firms' investment decisions both directly and through its interaction with firm reputation.

Journal ArticleDOI
TL;DR: The authors advocate for the integration of transgender spectrum experiences alongside cisgender experiences (i.e., having the same current gender identity label as one's birth-assigned gender category) to integrate the spectrum experiences.
Abstract: We advocate for the integration of transgender spectrum experiences alongside cisgender experiences (i.e., having the same current gender identity label as one's birth-assigned gender category) to ...

Journal ArticleDOI
TL;DR: In this paper, the authors compare measurements derived from XMM and Chandra observations with one another and compare both to gravitational lensing mass profiles derived with CLASH Hubble Space Telescope and Subaru Telescope lensing data.
Abstract: We present profiles of temperature, gas mass, and hydrostatic mass estimated from new and archival X-ray observations of CLASH clusters. We compare measurements derived from XMM and Chandra observations with one another and compare both to gravitational lensing mass profiles derived with CLASH Hubble Space Telescope and Subaru Telescope lensing data. Radial profiles of Chandra and XMM measurements of electron density and enclosed gas mass are nearly identical, indicating that differences in hydrostatic masses inferred from X-ray observations arise from differences in gas-temperature measurements. Encouragingly, gas temperatures measured in clusters by XMM and Chandra are consistent with one another at ~100–200 kpc radii, but XMM temperatures systematically decline relative to Chandra temperatures at larger radii. The angular dependence of the discrepancy suggests that additional investigation on systematics such as the XMM point-spread function correction, vignetting, and off-axis responses is yet required. We present the CLASH-X mass-profile comparisons in the form of cosmology-independent and redshift-independent circular-velocity profiles. We argue that comparisons of circular-velocity profiles are the most robust way to assess mass bias. Ratios of Chandra hydrostatic equilibrium (HSE) mass profiles to CLASH lensing profiles show no obvious radial dependence in the 0.3–0.8 Mpc range. However, the mean mass biases inferred from the weak-lensing (WL) and SaWLens data are different. As an example, the weighted-mean value at 0.5 Mpc is 〈b〉 = 0.12 for the WL comparison and 〈b〉 = −0.11 for the SaWLens comparison. The ratios of XMM HSE mass profiles to CLASH lensing profiles show a pronounced radial dependence in the 0.3–1.0 Mpc range, with a weighted mean mass bias value rising to 〈b〉 gsim 0.3 at ~1 Mpc for the WL comparison and 〈b〉 ≈ 0.25 for the SaWLens comparison. The enclosed gas mass profiles from both Chandra and XMM rise to a value ≈1/8 times the total-mass profiles inferred from lensing at ≈0.5 Mpc and remain constant outside of that radius, suggesting that M_gas × 8 profiles may be an excellent proxy for total-mass profiles at ≳ 0.5 Mpc in massive galaxy clusters.

Journal ArticleDOI
TL;DR: Strategies for making grading more supportive of learning are suggested, including balancing accuracy-based and effort-based grading, using self/peer evaluation, curtailing curved grading, and exercising skepticism about the meaning of grades.
Abstract: The authors explore a history of grading and review the literature regarding the purposes and impacts of grading. They then suggest strategies for making grading more supportive of learning, includ...

Journal ArticleDOI
TL;DR: In this article, Chandra and XMM-Newton observations of the globular clusters omega Cen and NGC 6397 were used to measure the spectrum of quiescent neutron stars (NSs), and thus to constrain the allowed ranges of mass and radius for each.
Abstract: We use Chandra and XMM-Newton observations of the globular clusters omega Cen and NGC 6397 to measure the spectrum of their quiescent neutron stars (NSs), and thus to constrain the allowed ranges of mass and radius for each. We also use Hubble Space Telescope photometry of NGC 6397 to identify a potential optical companion to the quiescent NS, and find evidence that the companion lacks hydrogen. We carefully consider a number of systematic problems, and show that the choices of atmospheric composition, interstellar medium abundances, and cluster distances can have important effects on the inferred NS mass and radius. We find that for typical NS masses, the radii of both NSs are consistent with the 10-13 km range favoured by recent nuclear physics experiments. This removes the evidence suggested by Guillot and collaborators for an unusually small NS radius, which relied upon the small inferred radius of the NGC 6397 NS.

Journal ArticleDOI
Christopher D. Shaffer1, Consuelo J. Alvarez2, April E. Bednarski1, April E. Bednarski3, David Dunbar4, Anya Goodman5, Catherine Reinke6, Anne G. Rosenwald7, Michael J. Wolyniak8, Cheryl Bailey9, Daron C. Barnard10, Christopher Bazinet11, Dale L. Beach2, James E. J. Bedard12, James E. J. Bedard13, Satish C. Bhalla14, John M. Braverman, Martin G. Burg, Vidya Chandrasekaran15, Hui-Min Chung16, Kari Clase17, Randall J. DeJong18, Justin R. DiAngelo19, Chunguang Du20, Todd T. Eckdahl21, Heather L. Eisler22, Julia A. Emerson23, Amy Frary, Donald R. Frohlich24, Yuying Gosser25, Shubha Govind25, Adam Haberman26, Adam Haberman27, Amy T. Hark28, Charles R. Hauser29, Arlene J. Hoogewerf18, Laura L. Mays Hoopes30, Carina E. Howell31, Diana S Johnson32, Christopher J. Jones33, Lisa Kadlec34, Marian M. Kaehler35, S. Catherine Silver Key36, Adam Kleinschmit13, Nighat P. Kokan37, Olga R. Kopp38, Gary A Kuleck39, Gary A Kuleck40, Judith Leatherman41, Jane Lopilato42, Christy MacKinnon43, Juan Carlos Martínez-Cruzado44, Gerard P. McNeil25, Stephanie F. Mel45, Hemlata Mistry46, Alexis Nagengast46, Paul J. Overvoorde47, Don W. Paetkau15, Susan Parrish, Celeste Peterson48, Mary L. Preuss49, Laura K. Reed50, Dennis Revie51, Srebrenka Robic52, Jennifer Roecklein-Canfield42, Michael R. Rubin53, Kenneth Saville54, Stephanie Schroeder49, Karim A. Sharif55, Karim A. Sharif25, Mary E. Shaw56, Gary R. Skuse57, Christopher D. Smith58, Mary A. Smith59, Sheryl T. Smith60, Eric P. Spana61, Mary Spratt62, Aparna Sreenivasan63, Joyce Stamm64, Paul Szauter65, Jeffrey S. Thompson66, Matthew Wawersik67, James J. Youngblom68, Leming Zhou69, Elaine R. Mardis1, Jeremy Buhler, Wilson Leung1, David Lopatto70, Sarah C. R. Elgin1 
Washington University in St. Louis1, Longwood University2, Lindenwood University3, Cabrini College4, California Polytechnic State University5, Linfield College6, Georgetown University7, Hampden–Sydney College8, University of Nebraska–Lincoln9, Worcester State University10, St. John's University11, University of the Fraser Valley12, Adams State University13, Johnson C. Smith University14, Saint Mary's College of California15, University College West16, Purdue University17, Calvin College18, Hofstra University19, Montclair State University20, Missouri Western State University21, University of the Cumberlands22, Amherst College23, University of St. Thomas (Minnesota)24, City University of New York25, University of San Diego26, Oberlin College27, Muhlenberg College28, St. Edward's University29, Pomona College30, Lock Haven University of Pennsylvania31, George Washington University32, Moravian College33, Wilkes University34, Luther College35, North Carolina Central University36, Cardinal Stritch University37, Utah Valley University38, University of Detroit Mercy39, Loyola Marymount University40, University of Northern Colorado41, Simmons College42, University of the Incarnate Word43, University of Puerto Rico at Mayagüez44, University of California, San Diego45, Widener University46, Macalester College47, Suffolk University48, Webster University49, University of Alabama50, California Lutheran University51, Agnes Scott College52, University of Puerto Rico53, Albion College54, Massasoit Community College55, New Mexico Highlands University56, Rochester Institute of Technology57, San Francisco State University58, North Carolina Agricultural and Technical State University59, Arcadia University60, Duke University61, William Woods University62, California State University, Monterey Bay63, University of Evansville64, University of New Mexico65, Denison University66, College of William & Mary67, California State University, Stanislaus68, University of Pittsburgh69, Grinnell College70
TL;DR: While course-based research in genomics can generate both knowledge gains and a greater appreciation for how science is done, a significant investment of course time is required to enable students to show gains commensurate to a summer research experience.
Abstract: There is widespread agreement that science, technology, engineering, and mathematics programs should provide undergraduates with research experience. Practical issues and limited resources, however, make this a challenge. We have developed a bioinformatics project that provides a course-based research experience for students at a diverse group of schools and offers the opportunity to tailor this experience to local curriculum and institution-specific student needs. We assessed both attitude and knowledge gains, looking for insights into how students respond given this wide range of curricular and institutional variables. While different approaches all appear to result in learning gains, we find that a significant investment of course time is required to enable students to show gains commensurate to a summer research experience. An alumni survey revealed that time spent on a research project is also a significant factor in the value former students assign to the experience one or more years later. We conclude: 1) implementation of a bioinformatics project within the biology curriculum provides a mechanism for successfully engaging large numbers of students in undergraduate research; 2) benefits to students are achievable at a wide variety of academic institutions; and 3) successful implementation of course-based research experiences requires significant investment of instructional time for students to gain full benefit.

Journal ArticleDOI
TL;DR: This article examined how family control affects whether firms tend to go international and found that family involvement in management has an inverted-U-shaped relationship with the likelihood of internationalization and that the percentage of family ownership has a U-shaped relation with internationalization.
Abstract: Applying the socioemotional wealth perspective of family businesses, this study examines how family control affects whether firms tend to go international. Departing from prior research that has treated family involvement in management and family ownership as interchangeable and inseparable, we suggest that they are two different aspects of family control, which independently and differently affect firms’ internationalization strategies. A sample of private Chinese firms supports our predictions that family involvement in management has an inverted-U-shaped relationship with the likelihood of internationalization and that the percentage of family ownership has a U-shaped relationship with the likelihood of internationalization.