San Francisco State University

About: San Francisco State University is a education organization based out in San Francisco, California, United States. It is known for research contribution in the topics: Population & Planet. The organization has 5669 authors who have published 11433 publications receiving 408075 citations. The organization is also known as: San Francisco State & San Francisco State Normal School.

The multiplicity of the subgiant branch of ω centauri : Evidence for prolonged star formation

Abstract: We combine spectroscopic and photometric data for subgiant stars of ω Cen to extract results that neither data set could have provided on its own. GIRAFFE@VLT spectra of 80 stars at R = 6400 give metallicities for all of them and abundances of C, N, Ca, Ti, and Ba for a subset of them. The photometric data, which have unusually high accuracy, come from a ~10 × 10 arcmin2 mosaic of HST ACS images centered on the cluster center and on multicolor images of a ~34 × 33 arcmin2 field, taken with the WFI@ESO2.2m camera. Stars with [Fe/H] < -1.25 have a large magnitude spread on the flat part of the SGB. We interpret this as empirical evidence for an age spread, and from theoretical isochrones we derive a relative age for each star. Within the SGB region we identify four distinct stellar groups: (1) an old, metal-poor group ([Fe/H] ~ -1.7); (2) an old, metal-rich group ([Fe/H] ~ -1.1); (3) a young (up to 4-5 Gyr younger than the old component) metal-poor group ([Fe/H] ~ -1.7); (4) a young, intermediate-metallicity ([Fe/H] ~ -1.4) group, on average 1-2 Gyr younger than the old metal-poor population, and with an age spread that we cannot properly quantify with the present sample. In addition, many SGB stars are spread between the intermediate-metallicity and metal-rich branches. We tentatively propose connections between the SGB stars and both the multiple main-sequence and the red giant branches. Finally, we discuss the implications of the multiple stellar populations on the formation and evolution of ω Cen. The spread in age within each population establishes that the original system must have had a composite nature.

Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

Abstract: Lung squamous cell carcinomas (LSCC) pathogenesis remains incompletely understood and biomarkers predicting treatment response remain lacking. Here we describe novel murine LSCC models driven by loss of Trp53 and Keap1, both of which are frequently mutated in human LSCCs. Homozygous inactivation of Keap1 or Trp53 promoted airway basal stem cell (ABSC) self-renewal, suggesting that mutations in these genes lead to expansion of mutant stem cell clones. Deletion of Trp53 and Keap1 in ABSCs, but not more differentiated tracheal cells, produced tumors recapitulating histological and molecular features of human LSCCs, indicating that they represent the likely cell of origin in this model. Deletion of Keap1 promoted tumor aggressiveness, metastasis, and resistance to oxidative stress and radiotherapy (RT). KEAP1/NRF2 mutation status predicted risk of local recurrence after RT in non-small lung cancer (NSCLC) patients and could be non-invasively identified in circulating tumor DNA. Thus, KEAP1/NRF2 mutations could serve as predictive biomarkers for personalization of therapeutic strategies for NSCLCs.

Asian Americans and Racism: When Bad Things Happen to "Model Minorities"

Abstract: Due to the limited psychological research on Asian Americans' experiences with racism, in the current study the authors examined the relationships between racial socialization, racial identity, and perceptions of racism, with a college-aged sample (N = 254) consisting primarily of Chinese Americans and Filipino Americans. With the use of multiple regression analyses, the results indicated that racial socialization, particularly discussions about race and racism, was positively related to one's perceptions of racism. Moreover, the study also showed that the relationship between racial socialization and perceptions of racism was partially mediated by racial identity schemas. To understand how Asian Americans regard racism, it is useful to have an understanding of racial identity theory and the manner in which Asian Americans are socialized to perceive racism.

Not as the crow flies: a historical explanation for circuitous migration in Swainson's thrush (Catharus ustulatus).

Abstract: Many migratory songbirds follow circuitous migratory routes instead of taking the shortest path between overwintering and breeding areas. Here, we study the migration patterns in Swainson's thrush (Catharus ustulatus), a neartic-neotropical migrant songbird, using molecular genetic approaches. This species is presently separated into genetically distinct coastal and continental populations that diverged during the Late Pleistocene (as indicated by molecular dating), yet appear to have retained ancestral patterns of migration. Low nucleotide diversity, a star-like haplotype phylogeny and unimodal mismatch distributions all support the hypothesis that both the coastal and the continental populations have undergone recent demographic expansions. Nearctic-neotropical banding and genetic data show nearly complete segregation of migratory routes and of overwintering locations: coastal populations migrate along the Pacific Coast to overwintering sites in Central America and Mexico, whereas continental populations migrate along an eastern route to overwintering sites in Panama and South America. Nearctic-neotropical banding data also show that continental birds north, northwest and east of this migratory divide fly thousands of miles east before turning south. We conclude that circuitous migration in the Swainson's thrush is an artefact of a Late Pleistocene range expansion.

Antisense Expression of a Cell Wall–Associated Protein Kinase, WAK4, Inhibits Cell Elongation and Alters Morphology

Abstract: The Arabidopsis cell wall–associated receptor-like kinase (WAK) gene family contains five highly related members whose products are suited for exchanging signals between the intracellular and extracellular compartments. WAK members are expressed in specific organs and regulated differentially by various biotic and abiotic factors. To gain further insight into how WAKs function during development, we used a glucocorticoid-inducible system to express ectopically the WAK4 antisense gene. The induced expression of the WAK4 antisense gene resulted in a significant decrease of WAK proteins. Ninety-six hours after the induction of WAK4 antisense expression, WAK proteins became undetectable. Cell elongation was impaired, and lateral root development was blocked. The level of WAK protein could be controlled by the concentration of the applied inducer, dexamethasone, and was correlated with the severity of the cell elongation inhibition phenotype. These results suggest that the WAKs serve a vital role in cell elongation and are required for plant development.