Institution
San Francisco State University
Education•San Francisco, California, United States•
About: San Francisco State University is a education organization based out in San Francisco, California, United States. It is known for research contribution in the topics: Population & Planet. The organization has 5669 authors who have published 11433 publications receiving 408075 citations. The organization is also known as: San Francisco State & San Francisco State Normal School.
Topics: Population, Planet, Poison control, Exoplanet, Planetary system
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Results suggest that the African finch Pyrenestes polymorphism may have arisen through single mutations, where morphs occupy distinct adaptive peaks through differences in feeding performance on seeds differing in hardness.
Abstract: MECHANISMS producing and maintaining discrete polymorphisms have long fascinated evolutionary biologists1,2. Despite the ubiquity of non-sex-limited polymorphisms in vertebrates, the evolutionary factors maintaining them are well understood in only a few instances3. The African finch Pyrenestes is unique among birds in exhibiting a non-sex-determined polymorphism in bill size4,5. Morphs breed randomly with respect to bill size and differ in diet and feeding performance on soft and hard seeds4,6. I present here: (1) new data showing that the polymorphism appears to result from a single genetic factor; (2) support from long-term field studies for earlier suggestions that disruptive selection is acting on bill size; and (3) data revealing the presence of a possible third, much larger morph. Results suggest that the polymorphism may have arisen through single mutations, where morphs occupy distinct adaptive peaks through differences in feeding performance on seeds differing in hardness.
194 citations
••
TL;DR: In this paper, a framework for the role of governance in regulating knowledge transfer in inter-firm exchange relationships is presented, with the goal of maximizing the benefits of learning while minimizing the risks.
Abstract: Organizational learning in inter‐firm exchange relationships poses a double‐edged sword. On one hand, inter‐firm learning is a desirable extension of organizational learning, developing a firm’s knowledge base, and providing fresh insights into strategies, markets, and relationships. On the other hand, inter‐firm learning can lead to unintended and undesirable skills transfer, resulting in the potential dilution of competitive advantage. This risk can be exacerbated by disparities in inter‐firm learning, resulting in uneven distribution of benefits and risks in the collaborative relationship. This paper articulates these two different views on inter‐firm learning, and second, develops a framework for the role of governance in regulating knowledge transfer. In particular, appropriate governance mechanisms must be crafted which match the learning intentions of the partners, the type of knowledge sought, and the designed duration for the collaboration, so as to maximize the benefits of learning while minimizing the risks. Implications for strategy and future research are offered.
194 citations
•
01 Jan 2006TL;DR: In this article, the authors present a survey of the state of the art in classroom research and discuss the role of teachers and learners in teaching and learning in the development of classroom discourse.
Abstract: Contents: Preface. Classroom Research. Researching Teachers and Learners. Researching Classroom Discourse. Writing Research Reports.
194 citations
••
TL;DR: The strategy to find fertility factors conserved from C. elegans to mammals achieved its goal: of mouse gene knockouts corresponding to nematode proteins, 37% (7/19) cause male sterility and provides significant opportunity to identify causes of male infertility and targets for male contraceptives.
Abstract: Male infertility is a long-standing enigma of significant medical concern. The integrity of sperm chromatin is a clinical indicator of male fertility and in vitro fertilization potential: chromosome aneuploidy and DNA decondensation or damage are correlated with reproductive failure. Identifying conserved proteins important for sperm chromatin structure and packaging can reveal universal causes of infertility. Here we combine proteomics, cytology and functional analysis in Caenorhabditis elegans to identify spermatogenic chromatin-associated proteins that are important for fertility. Our strategy employed multiple steps: purification of chromatin from comparable meiotic cell types, namely those undergoing spermatogenesis or oogenesis; proteomic analysis by multidimensional protein identification technology (MudPIT) of factors that co-purify with chromatin; prioritization of sperm proteins based on abundance; and subtraction of common proteins to eliminate general chromatin and meiotic factors. Our approach reduced 1,099 proteins co-purified with spermatogenic chromatin, currently the most extensive catalogue, to 132 proteins for functional analysis. Reduction of gene function through RNA interference coupled with protein localization studies revealed conserved spermatogenesis-specific proteins vital for DNA compaction, chromosome segregation, and fertility. Unexpected roles in spermatogenesis were also detected for factors involved in other processes. Our strategy to find fertility factors conserved from C. elegans to mammals achieved its goal: of mouse gene knockouts corresponding to nematode proteins, 37% (7/19) cause male sterility. Our list therefore provides significant opportunity to identify causes of male infertility and targets for male contraceptives.
194 citations
••
TL;DR: The functional results, presented here, are correlated to the x-ray structures of the mutants, and structural changes explain the functional alterations observed.
194 citations
Authors
Showing all 5744 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yuri S. Kivshar | 126 | 1845 | 79415 |
Debra A. Fischer | 121 | 567 | 54902 |
Sandro Galea | 115 | 1129 | 58396 |
Vijay S. Pande | 104 | 445 | 41204 |
Howard Isaacson | 103 | 575 | 42963 |
Paul Ekman | 99 | 235 | 84678 |
Russ B. Altman | 91 | 611 | 39591 |
John Kim | 90 | 406 | 41986 |
Santi Cassisi | 89 | 471 | 30757 |
Peng Zhang | 88 | 1578 | 33705 |
Michael D. Fayer | 84 | 537 | 26445 |
Raymond G. Carlberg | 84 | 316 | 28674 |
Geoffrey W. Marcy | 83 | 550 | 82309 |
Ten Feizi | 82 | 381 | 23988 |
John W. Eaton | 82 | 298 | 26403 |