Showing papers by "Sao Paulo State University published in 2019"
Edith Cowan University1, University of Queensland2, Utah State University3, Deakin University4, Autonomous University of Barcelona5, Charles Darwin University6, Commonwealth Scientific and Industrial Research Organisation7, University of Western Australia8, Sao Paulo State University9, Griffith University10, Southern Cross University11, University of New South Wales12, University of Wollongong13, Department of Water14, The Chinese University of Hong Kong15, Spanish National Research Council16, University of Tasmania17, University of Technology, Sydney18, National University of Malaysia19, Hasanuddin University20, University of Costa Rica21, Woods Hole Research Center22, King Abdullah University of Science and Technology23
TL;DR: This assessment, the most comprehensive for any nation to-date, demonstrates the potential of conservation and restoration of VCE to underpin national policy development for reducing greenhouse gas emissions.
Abstract: Policies aiming to preserve vegetated coastal ecosystems (VCE; tidal marshes, mangroves and seagrasses) to mitigate greenhouse gas emissions require national assessments of blue carbon resources. Here, we present organic carbon (C) storage in VCE across Australian climate regions and estimate potential annual CO2 emission benefits of VCE conservation and restoration. Australia contributes 5–11% of the C stored in VCE globally (70–185 Tg C in aboveground biomass, and 1,055–1,540 Tg C in the upper 1 m of soils). Potential CO2 emissions from current VCE losses are estimated at 2.1–3.1 Tg CO2-e yr-1, increasing annual CO2 emissions from land use change in Australia by 12–21%. This assessment, the most comprehensive for any nation to-date, demonstrates the potential of conservation and restoration of VCE to underpin national policy development for reducing greenhouse gas emissions. Policies aiming to preserve vegetated coastal ecosystems (VCE) to mitigate greenhouse gas emissions require national assessments of blue carbon resources. Here the authors assessed organic carbon storage in VCE across Australian and the potential annual CO2 emission benefits of VCE conservation and find that Australia contributes substantially the carbon stored in VCE globally.
1,462 citations
TL;DR: Combined measurements of the production and decay rates of the Higgs boson, as well as its couplings to vector bosons and fermions, are presented and constraints are placed on various two Higgs doublet models.
Abstract: Combined measurements of the production and decay rates of the Higgs boson, as well as its couplings to vector bosons and fermions, are presented. The analysis uses the LHC proton–proton collision data set recorded with the CMS detector in 2016 at $\sqrt{s}=13\,\text {Te}\text {V} $ , corresponding to an integrated luminosity of 35.9 ${\,\text {fb}^{-1}} $ . The combination is based on analyses targeting the five main Higgs boson production mechanisms (gluon fusion, vector boson fusion, and associated production with a $\mathrm {W}$ or $\mathrm {Z}$ boson, or a top quark-antiquark pair) and the following decay modes: $\mathrm {H} \rightarrow \gamma \gamma $ , $\mathrm {Z}\mathrm {Z}$ , $\mathrm {W}\mathrm {W}$ , $\mathrm {\tau }\mathrm {\tau }$ , $\mathrm {b} \mathrm {b} $ , and $\mathrm {\mu }\mathrm {\mu }$ . Searches for invisible Higgs boson decays are also considered. The best-fit ratio of the signal yield to the standard model expectation is measured to be $\mu =1.17\pm 0.10$ , assuming a Higgs boson mass of $125.09\,\text {Ge}\text {V} $ . Additional results are given for various assumptions on the scaling behavior of the production and decay modes, including generic parametrizations based on ratios of cross sections and branching fractions or couplings. The results are compatible with the standard model predictions in all parametrizations considered. In addition, constraints are placed on various two Higgs doublet models.
451 citations
TL;DR: In this article, a search for invisible decays of a Higgs boson via vector boson fusion is performed using proton-proton collision data collected with the CMS detector at the LHC in 2016 at a center-of-mass energy root s = 13 TeV, corresponding to an integrated luminosity of 35.9fb(-1).
347 citations
TL;DR: Recent and in-depth research of relevant works that deal with several intelligent techniques and their applied intrusion detection architectures in computer networks with emphasis on the Internet of Things and machine learning are aimed at.
299 citations
TL;DR: Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond, suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.
Abstract: Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved double bond into the backbone of ceramides and other predominant sphingolipids. Ablation of DES1 from whole animals or tissue-specific deletion in the liver and/or adipose tissue resolved hepatic steatosis and insulin resistance in mice caused by leptin deficiency or obesogenic diets. Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond. These studies suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.
254 citations
TL;DR: This large literature including studies on the effect of the mosquito microbiota on competence is reviewed, showing that it would be a great advance in this type of research to implement standardized procedures in order to obtain comparable and reproducible results.
232 citations
TL;DR: Passive acoustic monitoring (PAM) is quickly gaining ground in ecological research, following global trends toward automated data collection and big data as mentioned in this paper, using unattended sound recording, PAM provides tools for longterm and cost-effective biodiversity monitoring.
Abstract: Passive acoustic monitoring (PAM) is quickly gaining ground in ecological research, following global trends toward automated data collection and big data. Using unattended sound recording, PAM provides tools for long-term and cost-effective biodiversity monitoring. Still, the extent of the potential of this emerging method in terrestrial ecology is unknown. To quantify its application and guide future studies, we conducted a systematic review of terrestrial PAM, covering 460 articles published in 122 journals (1992–2018). During this period, PAM-related studies showed above a fifteenfold rise in publication and covered three developing phases: establishment, expansion, and consolidation. Overall, the research was mostly focused on bats (50%), occurred in northern temperate regions (65%), addressed activity patterns (25%), recorded at night (37%), used nonprogrammable recorders (61%), and performed manual acoustic analysis (58%), although their applications continue to diversify. The future agenda should include addressing the development of standardized procedures, automated analysis, and global initiatives to expand PAM to multiple taxa and regions.
224 citations
McMaster University1, Chosun University2, Dalhousie University3, Cochrane Collaboration4, Sao Paulo State University5, Wellington Management Company6, Texas A&M University7, University of East Anglia8, Jagiellonian University Medical College9, Population Health Research Institute10, University of Freiburg11, Harvard University12, City of Hope National Medical Center13
TL;DR: The Nutritional Recommendations (NutriRECS) international consortium was developed to produce rigorous evidence-based nutritional recommendations adhering to trustworthiness standards to produce trustworthy recommendations based on the values and preferences of guideline users.
Abstract: These guidelines from a Nutritional Recommendations (NutriRECS) international consortium address evidence-based recommendations concerning consumption of red meat and processed meat in adults.
215 citations
TL;DR: In this paper, the authors discuss perspectives for the use of compounds of botanical origin, as well as strategies employing the encapsulation techniques that can contribute to the development of systems for use in sustainable agricultural practices.
213 citations
Texas A&M University1, Université de Montréal2, Wake Forest University3, University of the Witwatersrand4, University of Cape Town5, ETH Zurich6, Aix-Marseille University7, Commonwealth Scientific and Industrial Research Organisation8, Universidade Federal de Santa Catarina9, University of Florida10, Universidade Federal de Minas Gerais11, Sao Paulo State University12, University of Minnesota13, Oregon State University14, North Carolina State University15, Technische Universität München16, Royal Botanic Garden Edinburgh17, University of Edinburgh18, Gembloux Agro-Bio Tech19, Kansas State University20, University of Sheffield21, Universidade Federal do Rio Grande do Sul22, University of Pretoria23, University of Liverpool24, Spanish National Research Council25, University of Exeter26, University of Western Australia27, Ghent University28, National Centre for Biological Sciences29, University of Leeds30, University of Brasília31, University of Bonn32, University of Freiburg33, Yale University34, Stellenbosch University35, University of Washington36, Lüneburg University37, Tall Timbers Research Station and Land Conservancy38
TL;DR: Bastin et al. as discussed by the authors estimated that tree planting for climate change mitigation could sequester 205 gigatonnes of carbon is approximately five times too large, which inflated soil organic carbon gains, failed to safeguard against warming from trees at high latitudes and elevations, and considered afforestation of savannas, grasslands, and shrublands to be restoration.
Abstract: Bastin et al.’s estimate (Reports, 5 July 2019, p. 76) that tree planting for climate change mitigation could sequester 205 gigatonnes of carbon is approximately five times too large. Their analysis inflated soil organic carbon gains, failed to safeguard against warming from trees at high latitudes and elevations, and considered afforestation of savannas, grasslands, and shrublands to be restoration.
207 citations
TL;DR: The impacts of green chemistry on pharmaceutical analyzes, environmental, population, analyst and company are described in this review and they are multidimensional.
Abstract: The growing process of industrialization was a milestone for world economic evolution. Since the 1940s, social movements have revolutionized green chemistry and provided shifts in industrial positions and sustainable processes with advances in environmental impact and awareness of companies and population. Paul Anastas and John Warner, in the 1990s, postulated the 12 principles of Green Chemistry, which are based on the minimization or non-use of toxic solvents in chemical processes and analyzes, as well as, the non-generation of residues from these processes. One of the most active areas of Research and Development in Green Chemistry is the development of analytical methodologies, giving rise to the so-called Green Analytical Chemistry. The impacts of green chemistry on pharmaceutical analyzes, environmental, population, analyst and company are described in this review and they are multidimensional. Every choice and analytical attitude has consequences both in the final product and in everything that surrounds it. The future of green chemistry as well as our future and the environment is also contemplated in this work.
TL;DR: This study indicated that 5 nm ZnO NP modified by GPTMS has great potential for use as an inorganic antibacterial material.
Aix-Marseille University1, Australian National University2, University of Western Australia3, Australian National Botanic Gardens4, Commonwealth Scientific and Industrial Research Organisation5, University of Oviedo6, University of Colorado Boulder7, University of Regensburg8, Universidade Federal de Minas Gerais9, Curtin University10, Royal Botanic Gardens11, Sao Paulo State University12, Murdoch University13, University of New South Wales14, Indonesian Institute of Sciences15, Middle Tennessee State University16
TL;DR: This work proposes broadening the range of morphological, physiological and biochemical seed traits to add new understanding on plant niches, population dynamics and community assembly and lays the foundation for a seed-trait functional network which will underpin and facilitate trait-based inferences.
Abstract: Trait-based approaches have improved our understanding of plant evolution, community assembly and ecosystem functioning. A major challenge for the upcoming decades is to understand the functions and evolution of early life-history traits, across levels of organization and ecological strategies. Although a variety of seed traits are critical for dispersal, persistence, germination timing and seedling establishment, only seed mass has been considered systematically. Here we suggest broadening the range of morphological, physiological and biochemical seed traits to add new understanding on plant niches, population dynamics and community assembly. The diversity of seed traits and functions provides an important challenge that will require international collaboration in three areas of research. First, we present a conceptual framework for a seed ecological spectrum that builds upon current understanding of plant niches. We then lay the foundation for a seed-trait functional network, the establishment of which will underpin and facilitate trait-based inferences. Finally, we anticipate novel insights and challenges associated with incorporating diverse seed traits into predictive evolutionary ecology, community ecology and applied ecology. If the community invests in standardized seed-trait collection and the implementation of rigorous databases, major strides can be made at this exciting frontier of functional ecology.
TL;DR: The old‐growth grassland concept, the novel ecosystem concept, and theory regarding tree cover along resource gradients in savannas are drawn on to propose a conceptual framework that classifies tropical grasslands into three broad ecosystem states.
Abstract: Despite growing recognition of the conservation values of grassy biomes, our understanding of how to maintain and restore biodiverse tropical grasslands (including savannas and open-canopy grassy woodlands) remains limited. To incorporate grasslands into large-scale restoration efforts, we synthesised existing ecological knowledge of tropical grassland resilience and approaches to plant community restoration. Tropical grassland plant communities are resilient to, and often dependent on, the endogenous disturbances with which they evolved - frequent fires and native megafaunal herbivory. In stark contrast, tropical grasslands are extremely vulnerable to human-caused exogenous disturbances, particularly those that alter soils and destroy belowground biomass (e.g. tillage agriculture, surface mining); tropical grassland restoration after severe soil disturbances is expensive and rarely achieves management targets. Where grasslands have been degraded by altered disturbance regimes (e.g. fire exclusion), exotic plant invasions, or afforestation, restoration efforts can recreate vegetation structure (i.e. historical tree density and herbaceous ground cover), but species-diverse plant communities, including endemic species, are slow to recover. Complicating plant-community restoration efforts, many tropical grassland species, particularly those that invest in underground storage organs, are difficult to propagate and re-establish. To guide restoration decisions, we draw on the old-growth grassland concept, the novel ecosystem concept, and theory regarding tree cover along resource gradients in savannas to propose a conceptual framework that classifies tropical grasslands into three broad ecosystem states. These states are: (1) old-growth grasslands (i.e. ancient, biodiverse grassy ecosystems), where management should focus on the maintenance of disturbance regimes; (2) hybrid grasslands, where restoration should emphasise a return towards the old-growth state; and (3) novel ecosystems, where the magnitude of environmental change (i.e. a shift to an alternative ecosystem state) or the socioecological context preclude a return to historical conditions.
TL;DR: In this article, the performance of missing transverse momentum (Tmiss) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center of mass energy of 13 TeV, collected at the CERN LHC in 2016.
Abstract: The performance of missing transverse momentum (Tmiss) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb-1. The results include measurements of the scale and resolution of Tmiss, and detailed studies of events identified with anomalous Tmiss. The performance is presented of a Tmiss reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed Tmiss with the hypothesis that it originates from resolution effects.
TL;DR: Brazil’s scientific community should rally to provide evidence that the inauguration of Jair Bolsonaro has heralded a rapid acceleration of the erosion of environmental protection measures.
Abstract: The inauguration of Jair Bolsonaro as Brazil’s new president has heralded a rapid acceleration of the erosion of environmental protection measures in the country. Brazil’s scientific community should rally to provide evidence that this is economically and socially unwise.
TL;DR: This review aims to describe the mechanisms of ZnO NPs toxicity against fungi and bacteria and how the different structural and physical-chemical characteristics of ZoNPs can interfere in their antimicrobial activity.
Abstract: The inappropriate use of antimicrobials has resulted in the selection of resistant strains. Thus, a great number of studies have focused on the investigation of new antimicrobial agents. The use of zinc oxide nanoparticles (ZnO NPs) to optimise the fight against microbial resistance has been receiving increased attention due to the non-specific activity of inorganic antimicrobial agents. The small particle size and the high surface area of ZnO NPs can enhance antimicrobial activity, causing an improvement in surface reactivity. In addition, surface modifiers covering ZnO NPs can play a role in mediating antimicrobial activity since the surface properties of nanomaterials alter their interactions with cells; this may interfere with the antimicrobial effect of ZnO NPs. The possibility of using surface modifiers with groups toxic to microorganisms can improve the antimicrobial activity of ZnO NPs. Understanding the exact toxicity mechanisms is crucial to elucidating the antimicrobial activity of ZnO NPs in bacteria and fungi. Therefore, this review aims to describe the mechanisms of ZnO NPs toxicity against fungi and bacteria and how the different structural and physical-chemical characteristics of ZnO NPs can interfere in their antimicrobial activity.
TL;DR: An overview of the available methods for studying propolis in different aspects is given in this article, where the authors give an overview of different aspects of propolis, such as propolis production in the bee colony, chemical composition and plant sources, biological activity, and standardization and quality control for industrial application.
Abstract: Propolis is one of the most fascinating honey bee (Apis mellifera L) products It is a plant derived product that bees produce from resins that they collect from different plant organs and with which they mix beeswax Propolis is a building material and a protective agent in the bee hive It also plays an important role in honey bee social immunity, and is widely used by humans as an ingredient of nutraceuticals, over-the-counter preparations and cosmetics Its chemical composition varies by geographic location, climatic zone and local flora The understanding of the chemical diversity of propolis is very important in propolis research In this manuscript, we give an overview of the available methods for studying propolis in different aspects: propolis in the bee colony; chemical composition and plant sources of propolis; biological activity of propolis with respect to bees and humans; and approaches for standardization and quality control for the purposes of industrial application
TL;DR: A search for Higgs boson pair production using the combined results from four final states: bbγγ, bbττ, bbbb, and bbVV, where V represents a W or Z boson, is performed using data collected in 2016 by the CMS experiment from LHC proton-proton collisions.
Abstract: This Letter describes a search for Higgs boson pair production using the combined results from four final states: bbγγ, bbττ, bbbb, and bbVV, where V represents a W or Z boson. The search is performed using data collected in 2016 by the CMS experiment from LHC proton-proton collisions at s=13 TeV, corresponding to an integrated luminosity of 35.9 fb-1. Limits are set on the Higgs boson pair production cross section. A 95% confidence level observed (expected) upper limit on the nonresonant production cross section is set at 22.2 (12.8) times the standard model value. A search for narrow resonances decaying to Higgs boson pairs is also performed in the mass range 250–3000 GeV. No evidence for a signal is observed, and upper limits are set on the resonance production cross section.
TL;DR: In vivo and in vitro studies were presented, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents.
Abstract: Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.
TL;DR: In this paper, the microstructure and mechanical properties of the as-built parts of HSLA steels are investigated, and are correlated with the thermal cycles involved in the process.
Abstract: Wire and arc additive manufacturing (WAAM) is a viable technique for the manufacture of large and complex dedicated parts used in structural applications. High-strength low-alloy (HSLA) steels are well-known for their applications in the tool and die industries and as power-plant components. The microstructure and mechanical properties of the as-built parts are investigated, and are correlated with the thermal cycles involved in the process. The heat input is found to affect the cooling rates, interlayer temperatures, and residence times in the 800–500 °C interval when measured using an infrared camera. The microstructural characterization performed by scanning electron microscopy reveals that the microstructural constituents of the sample remain unchanged. i.e., the same microstructural constituents—ferrite, bainite, martensite, and retained austenite are present for all heat inputs. Electron backscattered diffraction analysis shows that no preferential texture has been developed in the samples. Because of the homogeneity in the microstructural features of the as-built parts, the mechanical properties of the as-built parts are found to be nearly isotropic. Mechanical testing of samples shows excellent ductility and high mechanical strength. This is the first study elucidating on the effect of thermal cycles on the microstructure and mechanical properties during WAAM of HSLA steel.
TL;DR: In this paper, the implications of the adoption of circular economy business models on operations management (OM) decision-making processes, in the areas of product design, production planning and control, and logistics/supply chains, are examined and conceptualized.
University College London1, Rhodes University2, Fermilab3, Sao Paulo State University4, Autonomous University of Madrid5, University of Portsmouth6, University of Cambridge7, Carnegie Institution for Science8, University of Pennsylvania9, Institut d'Astrophysique de Paris10, Stanford University11, University of São Paulo12, University of Illinois at Urbana–Champaign13, IFAE14, Sun Yat-sen University15, Texas A&M University16, Indian Institute of Technology, Hyderabad17, University of Arizona18, California Institute of Technology19, University of Manchester20, University of Michigan21, Ludwig Maximilian University of Munich22, ETH Zurich23, University of California, Santa Cruz24, Ohio State University25, Max Planck Society26, Harvard University27, Australian Astronomical Observatory28, Argonne National Laboratory29, University of Geneva30, University of Sussex31, Universidade Federal do Rio Grande do Sul32, Brookhaven National Laboratory33, University of Southampton34, State University of Campinas35, Oak Ridge National Laboratory36
TL;DR: In this paper, the authors presented the results of a study at the Ohio State University's Center for Cosmology and Astro-Particle Physics (CSOP) at the University of Illinois at Urbana-Champaign.
Abstract: Ohio State University Center for Cosmology and AstroParticle Physics; Spanish Ramon y Cajal MICINN program; Spanish Ministerio de Economia y Competitividad [ESP2013-48274-C3-1-P]; Juan de la Cierva fellowship; Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Sao Paulo Research Foundation (FAPESP); CNPq; Instituto Nacional de Ciencia e Tecnologia (INCT) e-Universe (CNPq) [465376/2014-2]; 'Plan Estatal de Investigacion Cientfica y Tecnica y de Innovacion' program of the Spanish government; U.S. Department of Energy; U.S. National Science Foundation; Ministry of Science and Education of Spain; Science and Technology Facilities Council of the United Kingdom; Higher Education Funding Council for England; National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign; Kavli Institute of Cosmological Physics at the University of Chicago; Center for Cosmology and Astro-Particle Physics at the Ohio State University; Mitchell Institute for Fundamental Physics and Astronomy at Texas AM University; Financiadora de Estudos e Projetos; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico; Ministerio da Ciencia, Tecnologia e Inovacao; Deutsche Forschungsgemeinschaft; Argonne National Laboratory; University of California at Santa Cruz; University of Cambridge; Centro de Investigaciones Energeticas; Medioambientales y Tecnologicas-Madrid; University of Chicago; University College London; DES-Brazil Consortium; University of Edinburgh; Eidgenossische Technische Hochschule (ETH) Zurich; Fermi National Accelerator Laboratory; University of Illinois at Urbana-Champaign; Institut de Ciencies de l'Espai (IEEC/CSIC); Institut de Fisica d'Altes Energies; Lawrence Berkeley National Laboratory; Ludwig-Maximilians Universitat Munchen; associated Excellence Cluster Universe; University of Michigan; National Optical Astronomy Observatory; University of Nottingham; Ohio State University; University of Pennsylvania; University of Portsmouth; SLAC National Accelerator Laboratory; Stanford University; University of Sussex; Texas AM University; OzDES Membership Consortium; National Science Foundation [AST-1138766, AST-1536171]; MINECO [AYA2015-71825, ESP2015-66861, FPA2015-68048, SEV-2016-0588, SEV-2016-0597, MDM-2015-0509]; ERDF funds from the European Union; CERCA program of the Generalitat de Catalunya; European Research Council under the European Union; ERC [240672, 291329, 306478]; Australian Research Council Centre of Excellence [CE110001020]; U.S. Department of Energy, Office of Science, Office of High Energy Physics [DE-AC02-07CH11359]
TL;DR: The current status of stimuli-responsive release systems with potential to be used in agriculture are discussed, highlighting the challenges and drawbacks that need to be overcome in order to accelerate the global commercialization of smart nanopesticides.
Abstract: Pesticides and fertilizers are widely used to enhance agriculture yields, although the fraction of the pesticides applied in the field that reaches the targets is less than 0.1%. Such indiscriminate use of chemical pesticides is disadvantageous due to the cost implications and increasing human health and environmental concerns. In recent years, the utilization of nanotechnology to create novel formulations has shown great potential for diminishing the indiscriminate use of pesticides and providing environmentally safer alternatives. Smart nano-based pesticides are designed to efficiently delivery sufficient amounts of active ingredients in response to biotic and/or abiotic stressors that act as triggers, employing targeted and controlled release mechanisms. This review discusses the current status of stimuli-responsive release systems with potential to be used in agriculture, highlighting the challenges and drawbacks that need to be overcome in order to accelerate the global commercialization of smart nanopesticides.
TL;DR: In this article, the authors provide a comprehensive overview of recent research on electrochemical sensors based on molecularly imprinted polymers (MIPs) on nanostructured carbon material surfaces for electrochemical detection.
TL;DR: In this paper, a search for supersymmetric particles in the final state with multiple jets and large missing transverse momentum was performed using a sample of proton-proton collisions collected with the CMS detector.
Abstract: Results are reported from a search for supersymmetric particles in the final state with multiple jets and large missing transverse momentum. The search uses a sample of proton-proton collisions at $ \sqrt{s} $ = 13 TeV collected with the CMS detector in 2016–2018, corresponding to an integrated luminosity of 137 fb$^{−1}$, representing essentially the full LHC Run 2 data sample. The analysis is performed in a four-dimensional search region defined in terms of the number of jets, the number of tagged bottom quark jets, the scalar sum of jet transverse momenta, and the magnitude of the vector sum of jet transverse momenta. No significant excess in the event yield is observed relative to the expected background contributions from standard model processes. Limits on the pair production of gluinos and squarks are obtained in the framework of simplified models for supersymmetric particle production and decay processes. Assuming the lightest supersymmetric particle to be a neutralino, lower limits on the gluino mass as large as 2000 to 2310 GeV are obtained at 95% confidence level, while lower limits on the squark mass as large as 1190 to 1630 GeV are obtained, depending on the production scenario.
Albert M. Sirunyan1, Robin Erbacher2, C. A. Carrillo Montoya3, Wagner Carvalho4 +2322 more•Institutions (159)
TL;DR: In this article, the light-by-light scattering process in ultra-peripheral PbPb collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV is reported.
TL;DR: A systematic review of cohort studies addressing the association between red and processed meat consumption and all-cause mortality, cardiometabolic outcomes, quality of life, and satisfaction with diet among adults is presented.
Abstract: Growing evidence shows an increased risk for cardiometabolic disease associated with the consumption of red and processed meat. Although previous systematic reviews reported positive associations between red meat intake and all-cause mortality (1), cardiovascular mortality (2), and stroke (3) and between processed meat consumption and all-cause mortality (1, 4), cardiovascular mortality (2), stroke (3), coronary heart disease (5), and type 2 diabetes (5), results have not been consistent. One review did not find an association between unprocessed red meat and all-cause mortality (4), and another found no association with cardiovascular disease (5). Although Aune and colleagues (6) reported a relationship between red meat intake and type 2 diabetes, Micha and colleagues (5) did not detect this association in a review published 1 year later. Methodological limitations in previous reviews included failure to address risk of bias of primary studies (for example, references 3 and 6), lack of evaluation of certainty of evidence (for example, references 2 to 6), and failure to consider the magnitude of observed effect (for example, references 2 to 6). These limitations may have affected the credibility of recommendations issued by governments and authoritative organizations regarding red and processed meats. As part of NutriRECS (Nutritional Recommendations and accessible Evidence summaries Composed of Systematic reviews), a new initiative to establish trustworthy dietary recommendations that meet internationally accepted standards for guideline development, we developed guidelines addressing red and processed meat consumption (7). To inform these recommendations, we conducted 5 systematic reviews of the evidence (811). Here, we present results from a systematic review of cohort studies addressing the association between red and processed meat consumption and all-cause mortality, cardiometabolic outcomes, quality of life, and satisfaction with diet among adults. Methods We registered a protocol for this review at PROSPERO (CRD42017074074) in August 2017. Data Sources and Search Strategy An experienced research librarian developed the search strategy, which was used across all supporting reviews except the one addressing public values and preferences (Supplement 1). We searched MEDLINE, EMBASE (Elsevier), Cochrane Central Register of Controlled Trials (Wiley), Web of Science (Clarivate Analytics), CINAHL (EBSCO), and ProQuest from inception. We also reviewed reference lists of relevant systematic reviews. The final search of all databases included references up to July 2018, except for the MEDLINE search, which included references up to April 2019. Supplement. Search Strategy and Supplement Tables (Supplement 1) and Figures and Technical Appendix (Supplement 2) Study Selection We included cohort studies in any language that enrolled at least 1000 adults, compared participants consuming different amounts of unprocessed red meat or processed meat, and reported on 1 or more of our outcomes of interest. Red meat and processed meat were defined, respectively, as mammalian meat and white or red meat preserved by smoking, curing, salting, or adding chemical compounds (for example, hot dogs, charcuterie, sausage, ham, and deli meats) (12). We also included studies comparing vegetarians with nonvegetarians for sensitivity analyses. Our outcomes of interest were determined in consultation with our guideline panelwhich comprised members of the public, clinicians, epidemiologists, and methodologistsand include all-cause mortality, cardiovascular mortality (or fatal coronary heart disease or fatal myocardial infarction [MI]), cardiovascular disease (or coronary heart disease), stroke, MI, type 2 diabetes, anemia, quality of life, and satisfaction with diet. For studies reporting on ischemic and hemorrhagic stroke separately, we included results only for ischemic stroke in our meta-analyses (13). Cohorts in which more than 20% of the sample was younger than 18 years, had a noncardiometabolic disease (such as cancer), or was pregnant at baseline were excluded. We also excluded studies in which diet was assessed before adulthood, participants were asked to recall their diet before adulthood, or dietary assessments were completed by proxies, as well as studies that reported on specific components of red meat (such as iron or fat) or specific types of red meat (such as lamb). However, we did include studies reporting on beefpork combinations because beef and pork account for most red meat intake in most Western populations (14, 15). If we encountered more than 1 eligible article on the same exposure and cohort and addressing the same outcome, we included results only from the study with the longest follow-up. If the follow-up was the same, we chose the study with the most participants. Pairs of reviewers completed calibration exercises, after which they performed screening independently and in duplicate, with disagreements resolved by discussion or through third-party adjudication by an expert research methodologist. Screening was done in 2 stages: First, the reviewers assessed titles and abstracts; then, for those deemed potentially eligible, they evaluated the full-text articles. Data Extraction and Quality Assessment Using standardized, pilot-tested forms, reviewers completed calibration exercises and worked in pairs to independently extract the following information from eligible studies: cohort characteristics (such as cohort name and country), participant characteristics (including age and proportion who were female), diet characteristics (such as frequency and quantity of consumption of unprocessed red meat or processed meat), and outcomes (including absolute and relative effect measures for outcomes of interest and measures of variability). Disagreements between pairs of extractors were resolved through discussion or by third-party adjudication by an expert research methodologist. Reviewers, working independently and in duplicate, assessed each study's risk of bias by using the CLARITY (Clinical Advances Through Research and Information Translation) risk-of-bias instrument for cohort studies, omitting an item related to co-interventions that was not relevant to our review (16). Disagreements were resolved through discussion or by third-party adjudication. Research methodologists and nutrition researchers were consulted to confirm the appropriateness of the CLARITY instrument and to advise us regarding criteria for evaluating each of its items. The instrument and detailed guidance are presented in Supplement Table 1. Studies rated as high risk of bias on 2 or more of the 7 domains were considered to have a high overall risk of bias. This threshold, although somewhat arbitrary, represents a compromise between excessive stringency and leniency. Data Synthesis and Analysis We conducted separate analyses for unprocessed red meat, processed meat, and mixed unprocessed red and processed meat. If an article reported on red meat and did not specify whether it was processed or unprocessed, we assumed that it included both unprocessed and processed red meat. We included such studies in the analysis of mixed unprocessed red and processed meat because most processed meat is typically consumed as red meat (17, 18). For our primary analyses, we conducted a random-effects doseresponse meta-analysis using methods proposed by Greenland and Longnecker (19) and Orsini and colleagues (20). These methods require knowledge of the distribution of events and number of participants or person-years and mean or median quantity of intake across categories of exposure. When results from studies were analyzed across quantiles of intake but person-years or number of participants was not reported within each quantile, we estimated these values by using figures reported for the total population and dividing the total person-years or total number of participants by the number of quantiles. For studies reporting effect estimates stratified by participant characteristics (such as sex), we meta-analyzed across subgroups by using the fixed-effects model. For studies that treated the exposure as a continuous predictor in a logistic regression and did not present categorical analyses, we calculated a regression coefficient based on the relative effect reported and meta-analyzed these regression coefficients with effects from other studies obtained via the estimation method described by Greenland and Longnecker (19). These studies were excluded from the nonlinear analyses. For analyses including 5 or more studies, we tested for nonlinearity by using restricted cubic splines with knots at 10%, 50%, and 90% and a Wald-type test. For analyses in which we observed statistically significant nonlinear associations, we present results from the nonlinear model. For studies reporting the intake of red meat or processed meat as a range of values, we assigned the midpoint of upper and lower boundaries in each category as the average intake. If the highest or lowest category was open ended, we assumed that the open-ended interval was the same size as the adjacent interval. For studies reporting exposure as number of servings, we assumed that each serving of unprocessed red meat was equal to 120 g; processed meat, 50 g; and mixed unprocessed red and processed meat, 100 g. These serving sizes were selected for comparability with those used in other systematic reviews, as well as to reflect serving sizes used by the U.S. Department of Agriculture and United Kingdom Food Agency (13, 2125). We report results corresponding to the effects of a reduction in unprocessed red or processed meat intake of 3 servings per week. We used the dosresmeta package in R, version 3.5.1 (R Foundation for Statistical Computing), for our doseresponse meta-analyses (26). Further details about these meta-analyses, including sample code, are presented in Supplement 2. As a secondary analysis, we used the Har
TL;DR: In this article, it was shown that a difference of a factor of two in the pebble mass flux is enough to change the evolution from the terrestrial to the super-Earth growth mode.
Abstract: Super-Earths - planets with sizes between the Earth and Neptune - are found in tighter orbits than that of the Earth around more than one third of main sequence stars. It has been proposed that super-Earths are scaled-up terrestrial planets that also formed similarly, through mutual accretion of planetary embryos, but in discs much denser than the solar protoplanetary disc. We argue instead that terrestrial planets and super-Earths have two clearly distinct formation pathways that are regulated by the pebble reservoir of the disc. Through numerical integrations, which combine pebble accretion and N-body gravity between embryos, we show that a difference of a factor of two in the pebble mass flux is enough to change the evolution from the terrestrial to the super-Earth growth mode. If the pebble mass flux is small, then the initial embryos within the ice line grow slowly and do not migrate substantially, resulting in a widely spaced population of approximately Mars-mass embryos when the gas disc dissipates. Subsequently, without gas being present, the embryos become unstable due to mutual gravitational interactions and a small number of terrestrial planets are formed by mutual collisions. The final terrestrial planets are at most five Earth masses. Instead, if the pebble mass flux is high, then the initial embryos within the ice line rapidly become sufficiently massive to migrate through the gas disc. Embryos concentrate at the inner edge of the disc and growth accelerates through mutual merging. This leads to the formation of a system of closely spaced super-Earths in the five to twenty Earth-mass range, bounded by the pebble isolation mass. Generally, instabilities of these super-Earth systems after the disappearance of the gas disc trigger additional merging events and dislodge the system from resonant chains. Therefore, the key difference between the two growth modes is whether embryos grow fast enough to undergo significant migration. The terrestrial growth mode produces small rocky planets on wider orbits like those in the solar system whereas the super-Earth growth mode produces planets in short-period orbits inside 1 AU, with masses larger than the Earth that should be surrounded by a primordial H/He atmosphere, unless subsequently lost by stellar irradiation. The pebble flux - which controls the transition between the two growth modes - may be regulated by the initial reservoir of solids in the disc or the presence of more distant giant planets that can halt the radial flow of pebbles. (Less)
TL;DR: The present review is intended to highlight the recent advances related to boron-containing compounds and their therapeutic applications, and focused only in those most biologically active compounds with proven in-vitro and/or in vivo efficacy in the therapeutic area published in the last years.