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Institution

Sao Paulo State University

EducationSão Paulo, Brazil
About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.


Papers
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Journal ArticleDOI
TL;DR: BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom, was structurally and functionally characterized and displayed bactericidal activity and promoted the blockage of the neuromuscular contraction of the chick biventer cervicis muscle.

152 citations

Journal ArticleDOI
TL;DR: A fibrino(geno)lytic nonhemorrhagic metalloprotease (neuwiedase) was purified from Bothrops neuWiedi snake venom by a single chromatographic step procedure on a CM-Sepharose column.

152 citations

Journal ArticleDOI
TL;DR: Findings from this review suggest that genetics and early environment are possible mechanisms underlying the relationship between obesity and LBP; however, a direct causal link between these conditions appears to be weak.

152 citations

Journal ArticleDOI
TL;DR: This review attempts to suggest certain key points to be addressed in the current and future agri-nanotechnology researches on the basis of recognized knowledge gaps with strong recommendation of incorporating biosynthesized nanoparticles to carry out analogous functions.
Abstract: Nanotechnology representing a new frontier in modern agriculture is anticipated to become a major thrust in near future by offering potential applications. This integrating approach i.e. agri-nanotechnology has great potential to cope with global challenges of food production/security, sustainability and climate change. However, despite the potential benefits of nanotechnology in agriculture so far, their relevance has not reached up to the field conditions. The elevating concerns about fate, transport, bioavailability, nanoparticles toxicity and inappropriateness of regulatory framework limit the complete acceptance and inclination to adopt nanotechnologies in agricultural sector. Moreover, the current research trends lack realistic approach that fail to attain comprehensive knowledge of risk assessment factors and further toxicity of nanoparticles towards agroecosystem components viz. plant, soil, soil microbiomes after their release into the environment. Hence in the present review we attempt to suggest certain key points to be addressed in the current and future agri-nanotechnology researches on the basis of recognized knowledge gaps with strong recommendation of incorporating biosynthesized nanoparticles to carry out analogous functions. In this perspective, the major points are as follows: (i) Mitigating risk assessment factors (responsible for fate, transport, behavior, bioavailability and toxicity) for alleviating the subsequent toxicity of nanoparticles. (ii) Optimizing permissible level of nanoparticles dose within the safety limits by performing dose dependent studies. (iii) Adopting realistic approach by designing the experiments in natural habitat and avoiding in vitro assays for accurate interpretation. (iv) Most importantly, translating environmental friendly and non-toxic biosynthesized nanoparticles from laboratory to field conditions for agricultural benefits.

151 citations

Journal ArticleDOI
TL;DR: The xanthene dye Erythrosine, which showed the strongest effect, was selected for further investigation on mitochondria in vivo and it was determined that the concentration to give 50% inhibition was determined for some of the dyes.
Abstract: Eleven organic synthetic dyes, currently or formerly used as food colours in Brazil, were tested to determine their effect on mitochondrial respiration in mitochondria isolated from rat liver and kidney. The compounds tested were: Erythrosine, Ponceau 4R, Allura Red, Sunset yellow, Tartrazine, Amaranth, Brilliant Blue, Blue, Fast Red E, Orange GGN and Scarlet GN. All food colours tested inhibited mitochondrial respiration (State III respiration, uncoupled) supported either by alpha-ketoglutarate or succinate. This inhibition varied largely, e.g. from 100% to 16% for Erythrosine and Tartrazine respectively, at a concentration of 0.1 mg food colour per mitochondrial protein. Both rat liver and kidney mitochondria showed similar patterns of inhibition among the food colours tested. This effect was dose related and the concentration to give 50% inhibition was determined for some of the dyes. The xanthene dye Erythrosine, which showed the strongest effect, was selected for further investigation on mitochondria in vivo.

151 citations


Authors

Showing all 56201 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Tobin J. Marks1591621111604
Joseph T. Hupp14173182647
Luca Lista1402044110645
Sergio F Novaes1381559101941
Wagner Carvalho135139594184
Alberto Santoro1351576100629
Andre Sznajder134146498242
Luiz Mundim133141389792
Eduardo De Moraes Gregores133145492464
Helio Nogima132127484368
Pedro G Mercadante129133186378
D. De Jesus Damiao128116282707
Sandra S. Padula128113177174
Sudha Ahuja127101675739
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023127
2022765
20216,826
20206,949
20196,316
20186,314