Institution
Sao Paulo State University
Education•São Paulo, Brazil•
About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.
Papers published on a yearly basis
Papers
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TL;DR: Modulation of human DCs by noncytotoxic concentrations of antineoplastic drugs, i.e. chemomodulation, might represent a novel approach for up-regulation of functional activity of resident DCs in the tumor microenvironment or improving the efficacy of DCs prepared ex vivo for subsequent vaccinations.
Abstract: The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant number of patients but is associated with significant short-term and long-term toxicity. Recent data demonstrate that moderately low-dose chemotherapy may be efficiently combined with immunotherapy, particularly with dendritic cell (DC) vaccines, to improve the overall therapeutic efficacy. However, the direct effects of low and ultra-low concentrations on DCs are still unknown. Here we characterized the effects of low noncytotoxic concentrations of different classes of chemotherapeutic agents on human DCs in vitro. DCs treated with antimicrotubule agents vincristine, vinblastine, and paclitaxel or with antimetabolites 5-aza-2-deoxycytidine and methotrexate, showed increased expression of CD83 and CD40 molecules. Expression of CD80 on DCs was also stimulated by vinblastine, paclitaxel, azacytidine, methotrexate, and mitomycin C used in low nontoxic concentrations. Furthermore, 5-aza-2-deoxycytidine, methotrexate, and mitomycin C increased the ability of human DCs to stimulate proliferation of allogeneic T lymphocytes. Thus, our data demonstrate for the first time that in low noncytotoxic concentrations chemotherapeutic agents do not induce apoptosis of DCs, but directly enhance DC maturation and function. This suggests that modulation of human DCs by noncytotoxic concentrations of antineoplastic drugs, i.e. chemomodulation, might represent a novel approach for up-regulation of functional activity of resident DCs in the tumor microenvironment or improving the efficacy of DCs prepared ex vivo for subsequent vaccinations.
139 citations
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TL;DR: The oxidation of a reactive dye, Reactive Blue 4, RB4, (C.I. 61205), widely used in the textile industries to color natural fibers, was studied by electrochemical techniques.
139 citations
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TL;DR: Toluidine blue, methylene blue and malachite green were effective photosensitizers in antimicrobial photodynamic therapy against C. albicans, as was low-power laser irradiation alone, and the number of colony-forming units per milliliter was reduced.
Abstract: This study was to evaluate specific effects of photodynamic therapy (energy density 15.8 J/cm2, 26.3 J/cm2 and 39.5 J/cm2) using methylene blue, toluidine blue and malachite green as photosensitizers and low-power laser irradiation on the viability of Candida albicans. Suspensions of C. albicans containing 106 cells/ml were standardized in a spectrophotometer. For each dye, 120 assays, divided into four groups according to the following experimental conditions, were carried out: laser irradiation in the presence of the photosensitizer; laser irradiation only; treatment with the photosensitizer only; no exposure to laser light or photosensitizer. Next, serial dilutions were prepared and seeded onto Sabouraud dextrose agar for the determination of the number of colony-forming units per milliliter (CFU/ml). The results were subjected to analysis of variance and the Tukey test (P < 0.05). Photodynamic therapy using the photosensitizers tested was effective in reducing the number of C. albicans.. The number of CFU/ml was reduced by between 0.54 log10 and 3.07 log10 and depended on the laser energy density used. Toluidine blue, methylene blue and malachite green were effective photosensitizers in antimicrobial photodynamic therapy against C. albicans, as was low-power laser irradiation alone.
139 citations
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TL;DR: Differences between these strains are greater than previously assumed and that the biosystematic status of R. sanguineus ticks from South America should be re-evaluated.
139 citations
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Albert M. Sirunyan1, Robin Erbacher2, C. A. Carrillo Montoya3, Wagner Carvalho4 +2322 more•Institutions (159)
TL;DR: In this article, the light-by-light scattering process in ultra-peripheral PbPb collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV is reported.
139 citations
Authors
Showing all 56201 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Tobin J. Marks | 159 | 1621 | 111604 |
Joseph T. Hupp | 141 | 731 | 82647 |
Luca Lista | 140 | 2044 | 110645 |
Sergio F Novaes | 138 | 1559 | 101941 |
Wagner Carvalho | 135 | 1395 | 94184 |
Alberto Santoro | 135 | 1576 | 100629 |
Andre Sznajder | 134 | 1464 | 98242 |
Luiz Mundim | 133 | 1413 | 89792 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Helio Nogima | 132 | 1274 | 84368 |
Pedro G Mercadante | 129 | 1331 | 86378 |
D. De Jesus Damiao | 128 | 1162 | 82707 |
Sandra S. Padula | 128 | 1131 | 77174 |
Sudha Ahuja | 127 | 1016 | 75739 |