Institution
Sao Paulo State University
Education•São Paulo, Brazil•
About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.
Papers published on a yearly basis
Papers
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TL;DR: EIF5A and the hypusine biosynthetic enzymes are novel potential targets for intervention in aberrant cell proliferation, in view of the extraordinary specificity and functional significance of Hypusine-containing eIF 5A in mammalian cell proliferation.
Abstract: The unusual basic amino acid, hypusine [Ne-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, eukaryotic translation initiation factor 5A (eIF5A, eIF-5A). Hypusine is synthesized exclusively in this protein by two sequential enzymatic steps involving deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). The deoxyhypusine/hypusine synthetic pathway has evolved in archaea and eukaryotes, and eIF5A, DHS and DOHH are highly conserved suggesting a vital cellular function of eIF5A. Gene disruption and mutation studies in yeast and higher eukaryotes have provided valuable information on the essential nature of eIF5A and the deoxyhypusine/hypusine modification in cell growth and in protein synthesis. In view of the extraordinary specificity and functional significance of hypusine-containing eIF5A in mammalian cell proliferation, eIF5A and the hypusine biosynthetic enzymes are novel potential targets for intervention in aberrant cell proliferation.
305 citations
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TL;DR: To be functionally useful, oral implants have to pierce the gingiva or oral mucosa and enter the oral cavity, thus establishing a transmucosal connection between the external environment and the inner parts of the body.
Abstract: To be functionally useful, oral implants have to pierce the gingiva or oral mucosa and enter the oral cavity, thus establishing a transmucosal connection between the external environment and the inner parts of the body. In order to avoid bacterial penetration that could jeopardize either initial healing or long-term behaviour of implants, the formation of an early and long-standing effective barrier capable of biologically protecting the peri-implant structures is mandatory. The establishment of this soft tissue barrier is a critical part of tissue integration and is fundamentally the result of wound healing that has to establish an effective interface between living tissues and a foreign body. The soft tissue interface has been histologically assessed in animals and has a dimension of 3–4 mm in the apico-coronal direction called ‘biological width’. The interface consists of two zones, one of epithelium which covers about 2 mm of the surface, while the rest is devoted to connective tissue adhesion. Both these tissues contribute to the establishment of the so-called biological width, which may prevent oral bacteria and their products from penetrating into the body (Berglundh et al. 1991; Buser et al. 1992; Berglundh & Lindhe 1996; Abrahamsson et al. 1996, 1997, 1998a, 1998b; Cochran et al. 1997).
304 citations
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S. Chatrchyan1, Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1 +3948 more•Institutions (144)
TL;DR: In this article, a search for the pair production of top squarks in events with a single isolated electron or muon, jets, large missing transverse momentum, and large transverse mass is presented.
Abstract: This paper presents a search for the pair production of top squarks in events with a single isolated electron or muon, jets, large missing transverse momentum, and large transverse mass. The data sample corresponds to an integrated luminosity of 19.5 inverse femtobarns of pp collisions collected in 2012 by the CMS experiment at the LHC at a center-of-mass energy of sqrt(s) = 8 TeV. No significant excess in data is observed above the expectation from standard model processes. The results are interpreted in the context of supersymmetric models with pair production of top squarks that decay either to a top quark and a neutralino or to a bottom quark and a chargino. For small mass values of the lightest supersymmetric particle, top-squark mass values up to around 650 GeV are excluded.
304 citations
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TL;DR: This study provides the first evidence for possible sexual reproduction in P. brasiliensis S1, but does not rule it out in the other two species.
Abstract: Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, a disease confined to Latin America and of marked importance in the endemic areas due to its frequency and severity. This species is considered to be clonal according to mycological criteria and has been shown to vary in virulence. To characterize natural genetic variation and reproductive mode in this fungus, we analyzed P. brasiliensis phylogenetically in search of cryptic species and possible recombination using concordance and nondiscordance of gene genealogies with respect to phylogenies of eight regions in five nuclear loci. Our data indicate that this fungus consists of at least three distinct, previously unrecognized species: S1 (species 1 with 38 isolates), PS2 (phylogenetic species 2 with six isolates), and PS3 (phylogenetic species 3 with 21 isolates). Genealogies of four of the regions studied strongly supported the PS2 clade, composed of five Brazilian and one Venezuelan isolate. The second clade, PS3, composed solely of 21 Colombian isolates, was strongly supported by the alpha-tubulin genealogy. The remaining 38 individuals formed S1. Two of the three lineages of P. brasiliensis, S1 and PS2, are sympatric across their range, suggesting barriers to gene flow other than geographic isolation. Our study provides the first evidence for possible sexual reproduction in P. brasiliensis S1, but does not rule it out in the other two species.
303 citations
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Albert M. Sirunyan1, Robin Erbacher2, C. A. Carrillo Montoya3, Wagner Carvalho4 +2355 more•Institutions (153)
TL;DR: In this paper, the performance of the modified system is studied using proton-proton collision data at center-of-mass energy √s=13 TeV, collected at the LHC in 2015 and 2016.
Abstract: The CMS muon detector system, muon reconstruction software, and high-level trigger underwent significant changes in 2013–2014 in preparation for running at higher LHC collision energy and instantaneous luminosity. The performance of the modified system is studied using proton-proton collision data at center-of-mass energy √s=13 TeV, collected at the LHC in 2015 and 2016. The measured performance parameters, including spatial resolution, efficiency, and timing, are found to meet all design specifications and are well reproduced by simulation. Despite the more challenging running conditions, the modified muon system is found to perform as well as, and in many aspects better than, previously. We dedicate this paper to the memory of Prof. Alberto Benvenuti, whose work was fundamental for the CMS muon detector.
303 citations
Authors
Showing all 56201 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Tobin J. Marks | 159 | 1621 | 111604 |
Joseph T. Hupp | 141 | 731 | 82647 |
Luca Lista | 140 | 2044 | 110645 |
Sergio F Novaes | 138 | 1559 | 101941 |
Wagner Carvalho | 135 | 1395 | 94184 |
Alberto Santoro | 135 | 1576 | 100629 |
Andre Sznajder | 134 | 1464 | 98242 |
Luiz Mundim | 133 | 1413 | 89792 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Helio Nogima | 132 | 1274 | 84368 |
Pedro G Mercadante | 129 | 1331 | 86378 |
D. De Jesus Damiao | 128 | 1162 | 82707 |
Sandra S. Padula | 128 | 1131 | 77174 |
Sudha Ahuja | 127 | 1016 | 75739 |