Sao Paulo State University

About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.

Maximal lactate steady state in running mice: effect of exercise training

Abstract: Univ Sao Paulo, Escola Educ Fis & Esporte, Dept Biodinam Movimento Corpo Humano, BR-05508900 Sao Paulo, Brazil

A ring system detected around the centaur (10199) chariklo

Abstract: Hitherto, rings have been found exclusively around the four giant planets in the Solar System(1). Rings are natural laboratories in which to study dynamical processes analogous to those that take place during the formation of planetary systems and galaxies. Their presence also tells us about the origin and evolution of the body they encircle. Here we report observations of a multichord stellar occultation that revealed the presence of a ring system around (10199) Chariklo, which is a Centaur-that is, one of a class of small objects orbiting primarily between Jupiter and Neptune-with an equivalent radius of 124 +/- 9 kilometres (ref. 2). There are two dense rings, with respective widths of about 7 and 3 kilometres, optical depths of 0.4 and 0.06, and orbital radii of 391 and 405 kilometres. The present orientation of the ring is consistent with an edge-on geometry in 2008, which provides a simple explanation for the dimming(3) of the Chariklo system between 1997 and 2008, and for the gradual disappearance of ice and other absorption features in its spectrum over the same period(4,5). This implies that the rings are partly composed of water ice. They may be the remnants of a debris disk, possibly confined by embedded, kilometre-sized satellites.

Copy number variation of individual cattle genomes using next-generation sequencing

Abstract: Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often intractable. Using a read depth approach based on next-generation sequencing, we examined genome-wide copy number differences among five taurine (three Angus, one Holstein, and one Hereford) and one indicine (Nelore) cattle. Within mapped chromosomal sequence, we identified 1265 CNV regions comprising ~55.6-Mbp sequence--476 of which (~38%) have not previously been reported. We validated this sequence-based CNV call set with array comparative genomic hybridization (aCGH), quantitative PCR (qPCR), and fluorescent in situ hybridization (FISH), achieving a validation rate of 82% and a false positive rate of 8%. We further estimated absolute copy numbers for genomic segments and annotated genes in each individual. Surveys of the top 25 most variable genes revealed that the Nelore individual had the lowest copy numbers in 13 cases (~52%, χ(2) test; P-value <0.05). In contrast, genes related to pathogen- and parasite-resistance, such as CATHL4 and ULBP17, were highly duplicated in the Nelore individual relative to the taurine cattle, while genes involved in lipid transport and metabolism, including APOL3 and FABP2, were highly duplicated in the beef breeds. These CNV regions also harbor genes like BPIFA2A (BSP30A) and WC1, suggesting that some CNVs may be associated with breed-specific differences in adaptation, health, and production traits. By providing the first individualized cattle CNV and segmental duplication maps and genome-wide gene copy number estimates, we enable future CNV studies into highly duplicated regions in the cattle genome.

Uso e diversidade de plantas medicinais em Santo Antonio do Leverger, MT, Brasil

Abstract: This work describes an ethnobotanical survey of medicinal plants in Santo Antonio do Leverger Municipality, Mato Grosso State, Brazil and estimates the diversity of species with therapeutic use. Adult dwellers, male and female, were interviewed and plant gathering undertaken with their assistance. Voucher specimens were deposited at the Herbarium Rioclarense (HRCB). 228 species were identified, belonging to 73 families; 56% of the species grow spontaneously in natural and anthropically modified habitats, 41% are cultivated and 3% are purchased. Diversity indexes are among the highest ones reported in literature for medicinal plants in other tropical areas. Richness and diversity of spontaneous species may mirror to certain extent environmental richness and diversity, whereas for cultivated species, these measures could be linked to socio-cultural factors enhancing introduction of new plants and use information from outside the area. It is suggested that when traditional communities become more exposed to society at large, species number and knowledge about their use may at first increase, by foreign input; but, with the socio-economic changes that come about over time, plants used for therapeutic aims will be limited to the cultivated species and cosmopolite weeds.