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Institution

Sao Paulo State University

EducationSão Paulo, Brazil
About: Sao Paulo State University is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 55715 authors who have published 100436 publications receiving 1375332 citations.


Papers
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Journal ArticleDOI
TL;DR: Estimation analyses and functional studies suggest that UCPs regulate energy metabolism in the cellular responses to stress through regulation of the electrochemical proton potential (Deltamu(H)+) and production of reactive oxygen species.
Abstract: Uncoupling proteins (UCPs) are membrane proteins that mediate purine nucleotide-sensitive free fatty acid-activated H+ flux through the inner mitochondrial membrane. After the discovery of UCP in higher plants in 1995, it was acknowledged that these proteins are widely distributed in eukaryotic organisms. The widespread presence of UCPs in eukaryotes implies that these proteins may have functions other than thermogenesis. In this review, we describe the current knowledge of plant UCPs, including their discovery, biochemical properties, distribution, gene family, gene expression profiles, regulation of gene expression, and evolutionary aspects. Expression analyses and functional studies on the plant UCPs under normal and stressful conditions suggest that UCPs regulate energy metabolism in the cellular responses to stress through regulation of the electrochemical proton potential (ΔμH+) and production of reactive oxygen species.

207 citations

Journal ArticleDOI
TL;DR: The value of these methods for the diagnosis of oral and systemic diseases has been the subject of study by several researchers with the aim of increasing its use alongside complementary exams.

207 citations

Journal ArticleDOI
TL;DR: This review tries to provide a general overview of the main aspects of Amphotericin B, and highlight the multiple effects that this molecule has on both the fungal and host cells.
Abstract: “Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol” is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of AmB is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells.

207 citations

Journal ArticleDOI
01 Oct 2013-PLOS ONE
TL;DR: The largest meta-analysis to date of phenological drivers and trends among southern hemisphere species, assessing 1208 long-term datasets from 89 studies on 347 species shows an advance in the timing of spring events, although substantial differences were apparent among taxonomic groups and regions.
Abstract: Current evidence of phenological responses to recent climate change is substantially biased towards northern hemisphere temperate regions. Given regional differences in climate change, shifts in phenology will not be uniform across the globe, and conclusions drawn from temperate systems in the northern hemisphere might not be applicable to other regions on the planet. We conduct the largest meta-analysis to date of phenological drivers and trends among southern hemisphere species, assessing 1208 long-term datasets from 89 studies on 347 species. Data were mostly from Australasia (Australia and New Zealand), South America and the Antarctic/subantarctic, and focused primarily on plants and birds. This meta-analysis shows an advance in the timing of spring events (with a strong Australian data bias), although substantial differences in trends were apparent among taxonomic groups and regions. When only statistically significant trends were considered, 82% of terrestrial datasets and 42% of marine datasets demonstrated an advance in phenology. Temperature was most frequently identified as the primary driver of phenological changes; however, in many studies it was the only climate variable considered. When precipitation was examined, it often played a key role but, in contrast with temperature, the direction of phenological shifts in response to precipitation variation was difficult to predict a priori. We discuss how phenological information can inform the adaptive capacity of species, their resilience, and constraints on autonomous adaptation. We also highlight serious weaknesses in past and current data collection and analyses at large regional scales (with very few studies in the tropics or from Africa) and dramatic taxonomic biases. If accurate predictions regarding the general effects of climate change on the biology of organisms are to be made, data collection policies focussing on targeting data-deficient regions and taxa need to be financially and logistically supported.

207 citations

Journal ArticleDOI
TL;DR: In this article, a simple and fast microwave-hydrothermal method at 130°C for 20min was used to synthesize crystalline ceria (CeO2) nanoparticles, which were characterized by thermogravimetric analysis (TG-DTA), X-ray powder diffraction (XRD), field-emission scanning electron microscopy/STEM mode (FEG/STEM), Fourier transformed-IR and RAMAN spectroscopies.

207 citations


Authors

Showing all 56201 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Tobin J. Marks1591621111604
Joseph T. Hupp14173182647
Luca Lista1402044110645
Sergio F Novaes1381559101941
Wagner Carvalho135139594184
Alberto Santoro1351576100629
Andre Sznajder134146498242
Luiz Mundim133141389792
Eduardo De Moraes Gregores133145492464
Helio Nogima132127484368
Pedro G Mercadante129133186378
D. De Jesus Damiao128116282707
Sandra S. Padula128113177174
Sudha Ahuja127101675739
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023127
2022765
20216,826
20206,949
20196,316
20186,314