Institution
Sapienza University of Rome
Education•Rome, Lazio, Italy•
About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.
Papers published on a yearly basis
Papers
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University of Sussex1, Erasmus University Rotterdam2, University of Barcelona3, Odense University4, Sapienza University of Rome5, Stockholm School of Economics6, University of Bern7, Clark University8, Economic and Social Research Institute9, University of Lisbon10, University of Bristol11, Paris Dauphine University12, Uppsala University13
TL;DR: This paper presents further international comparisons of progressivity of health care financing systems, modifying the methodology used there and achieving a higher degree of cross-country comparability in variable definitions, and updating and extending the cross-section of countries.
461 citations
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TL;DR: It is described that PINK1 mutations confer different autophosphorylation activity, which is regulated by the C-terminal portion of the protein, and the mitochondrial localization of both wild-type and mutant Pink1 proteins unequivocally.
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative illness associated with a selective loss of dopaminergic neurons in the nigrostriatal pathway of the brain. Despite the overall rarity of the familial forms of PD, the identification of single genes linked to the disease has yielded crucial insights into possible mechanisms of neurodegeneration. Recently, a putative mitochondrial kinase, PINK1, has been found mutated in an inherited form of parkinsonism. Here, we describe that PINK1 mutations confer different autophosphorylation activity, which is regulated by the C-terminal portion of the protein. We also demonstrate the mitochondrial localization of both wild-type and mutant PINK1 proteins unequivocally and prove that a short N-terminal part of PINK1 is sufficient for its mitochondrial targeting.
461 citations
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TL;DR: In this article, a class of multivariable nonlinear systems can be stabilized about an equilibrium via smooth state feedback, and conditions under which, for every compact set of initial states, it is possible to design a feedback law which drives to the equilibrium all initial states in this compact set.
Abstract: How a class of multivariable nonlinear systems can be stabilized about an equilibrium via smooth state feedback is shown. More precisely, conditions under which, for every compact set of initial states, it is possible to design a feedback law which drives to the equilibrium all initial states in this compact set are described. The theory includes the development of globally defined transformations of the system equations to their global normal form. >
461 citations
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TL;DR: In this article, the authors propose a discrete-time formulation of the problem of contact-based epidemic spreading, and resolve a family of models, parameterized by the number of stochastic contact trials per unit time, that range from the contact process (CP) to the reactive process (RP).
Abstract: Many epidemic processes in networks spread by stochastic contacts among their connected vertices. There are two limiting cases widely analyzed in the physics literature, the so-called contact process (CP) where the contagion is expanded at a certain rate from an infected vertex to one neighbor at a time, and the reactive process (RP) in which an infected individual effectively contacts all its neighbors to expand the epidemics. However, a more realistic scenario is obtained from the interpolation between these two cases, considering a certain number of stochastic contacts per unit time. Here we propose a discrete-time formulation of the problem of contact-based epidemic spreading. We resolve a family of models, parameterized by the number of stochastic contact trials per unit time, that range from the CP to the RP. In contrast to the common heterogeneous mean-field approach, we focus on the probability of infection of individual nodes. Using this formulation, we can construct the whole phase diagram of the different infection models and determine their critical properties.
461 citations
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TL;DR: It is found that dislocations generate a slowly evolving configuration landscape which coexists with rapid collective rearrangements and should provide a framework for discussing fundamental aspects of plasticity that goes beyond standard mean-field approaches that see plastic deformation as a smooth laminar flow.
Abstract: The viscoplastic deformation (creep) of crystalline materials under constant stress involves the motion of a large number of interacting dislocations. Analytical methods and sophisticated 'dislocation dynamics' simulations have proved very effective in the study of dislocation patterning, and have led to macroscopic constitutive laws of plastic deformation. Yet, a statistical analysis of the dynamics of an assembly of interacting dislocations has not hitherto been performed. Here we report acoustic emission measurements on stressed ice single crystals, the results of which indicate that dislocations move in a scale-free intermittent fashion. This result is confirmed by numerical simulations of a model of interacting dislocations that successfully reproduces the main features of the experiment. We find that dislocations generate a slowly evolving configuration landscape which coexists with rapid collective rearrangements. These rearrangements involve a comparatively small fraction of the dislocations and lead to an intermittent behaviour of the net plastic response. This basic dynamical picture appears to be a generic feature in the deformation of many other materials. Moreover, it should provide a framework for discussing fundamental aspects of plasticity that goes beyond standard mean-field approaches that see plastic deformation as a smooth laminar flow.
461 citations
Authors
Showing all 62745 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Peter A. R. Ade | 162 | 1387 | 138051 |
H. Eugene Stanley | 154 | 1190 | 122321 |
Suvadeep Bose | 154 | 960 | 129071 |
P. de Bernardis | 152 | 680 | 117804 |
Bart Staels | 152 | 824 | 86638 |
Alessandro Melchiorri | 151 | 674 | 116384 |
Andrew H. Jaffe | 149 | 518 | 110033 |
F. Piacentini | 149 | 531 | 108493 |
Subir Sarkar | 149 | 1542 | 144614 |
Albert Bandura | 148 | 255 | 276143 |
Carlo Rovelli | 146 | 1502 | 103550 |
Robert C. Gallo | 145 | 825 | 68212 |
R. Kowalewski | 143 | 1815 | 135517 |