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Institution

Sapienza University of Rome

EducationRome, Lazio, Italy
About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.


Papers
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Journal ArticleDOI
TL;DR: This paper presents further international comparisons of progressivity of health care financing systems, modifying the methodology used there and achieving a higher degree of cross-country comparability in variable definitions, and updating and extending the cross-section of countries.

461 citations

Journal ArticleDOI
TL;DR: It is described that PINK1 mutations confer different autophosphorylation activity, which is regulated by the C-terminal portion of the protein, and the mitochondrial localization of both wild-type and mutant Pink1 proteins unequivocally.
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative illness associated with a selective loss of dopaminergic neurons in the nigrostriatal pathway of the brain. Despite the overall rarity of the familial forms of PD, the identification of single genes linked to the disease has yielded crucial insights into possible mechanisms of neurodegeneration. Recently, a putative mitochondrial kinase, PINK1, has been found mutated in an inherited form of parkinsonism. Here, we describe that PINK1 mutations confer different autophosphorylation activity, which is regulated by the C-terminal portion of the protein. We also demonstrate the mitochondrial localization of both wild-type and mutant PINK1 proteins unequivocally and prove that a short N-terminal part of PINK1 is sufficient for its mitochondrial targeting.

461 citations

Journal ArticleDOI
TL;DR: In this article, a class of multivariable nonlinear systems can be stabilized about an equilibrium via smooth state feedback, and conditions under which, for every compact set of initial states, it is possible to design a feedback law which drives to the equilibrium all initial states in this compact set.
Abstract: How a class of multivariable nonlinear systems can be stabilized about an equilibrium via smooth state feedback is shown. More precisely, conditions under which, for every compact set of initial states, it is possible to design a feedback law which drives to the equilibrium all initial states in this compact set are described. The theory includes the development of globally defined transformations of the system equations to their global normal form. >

461 citations

Journal ArticleDOI
01 Feb 2010-EPL
TL;DR: In this article, the authors propose a discrete-time formulation of the problem of contact-based epidemic spreading, and resolve a family of models, parameterized by the number of stochastic contact trials per unit time, that range from the contact process (CP) to the reactive process (RP).
Abstract: Many epidemic processes in networks spread by stochastic contacts among their connected vertices. There are two limiting cases widely analyzed in the physics literature, the so-called contact process (CP) where the contagion is expanded at a certain rate from an infected vertex to one neighbor at a time, and the reactive process (RP) in which an infected individual effectively contacts all its neighbors to expand the epidemics. However, a more realistic scenario is obtained from the interpolation between these two cases, considering a certain number of stochastic contacts per unit time. Here we propose a discrete-time formulation of the problem of contact-based epidemic spreading. We resolve a family of models, parameterized by the number of stochastic contact trials per unit time, that range from the CP to the RP. In contrast to the common heterogeneous mean-field approach, we focus on the probability of infection of individual nodes. Using this formulation, we can construct the whole phase diagram of the different infection models and determine their critical properties.

461 citations

Journal ArticleDOI
05 Apr 2001-Nature
TL;DR: It is found that dislocations generate a slowly evolving configuration landscape which coexists with rapid collective rearrangements and should provide a framework for discussing fundamental aspects of plasticity that goes beyond standard mean-field approaches that see plastic deformation as a smooth laminar flow.
Abstract: The viscoplastic deformation (creep) of crystalline materials under constant stress involves the motion of a large number of interacting dislocations. Analytical methods and sophisticated 'dislocation dynamics' simulations have proved very effective in the study of dislocation patterning, and have led to macroscopic constitutive laws of plastic deformation. Yet, a statistical analysis of the dynamics of an assembly of interacting dislocations has not hitherto been performed. Here we report acoustic emission measurements on stressed ice single crystals, the results of which indicate that dislocations move in a scale-free intermittent fashion. This result is confirmed by numerical simulations of a model of interacting dislocations that successfully reproduces the main features of the experiment. We find that dislocations generate a slowly evolving configuration landscape which coexists with rapid collective rearrangements. These rearrangements involve a comparatively small fraction of the dislocations and lead to an intermittent behaviour of the net plastic response. This basic dynamical picture appears to be a generic feature in the deformation of many other materials. Moreover, it should provide a framework for discussing fundamental aspects of plasticity that goes beyond standard mean-field approaches that see plastic deformation as a smooth laminar flow.

461 citations


Authors

Showing all 62745 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Gregory Y.H. Lip1693159171742
Peter A. R. Ade1621387138051
H. Eugene Stanley1541190122321
Suvadeep Bose154960129071
P. de Bernardis152680117804
Bart Staels15282486638
Alessandro Melchiorri151674116384
Andrew H. Jaffe149518110033
F. Piacentini149531108493
Subir Sarkar1491542144614
Albert Bandura148255276143
Carlo Rovelli1461502103550
Robert C. Gallo14582568212
R. Kowalewski1431815135517
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023405
20221,106
20219,796
20209,753
20198,332
20187,615