scispace - formally typeset
Search or ask a question
Institution

Sapienza University of Rome

EducationRome, Lazio, Italy
About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.


Papers
More filters
Journal ArticleDOI
07 Oct 2009-JAMA
TL;DR: Compared with placebo, BLF supplementation alone or in combination with LGG reduced the incidence of a first episode of late-onset sepsis in VLBW neonates.
Abstract: Context Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) ( Objective To establish whether bovine lactoferrin (BLF), alone or in combination with LGG, reduces the incidence of late-onset sepsis in VLBW neonates. Design, Setting, and Patients Prospective, multicenter, double-blind, placebo-controlled, randomized trial conducted in 11 Italian tertiary neonatal intensive care units. Patients were 472 VLBW infants enrolled from October 1, 2007, through July 31, 2008, and assessed until discharge for development of sepsis. Intervention Infants were randomly assigned to receive orally administered BLF (100 mg/d) alone (n = 153), BLF plus LGG (6 × 10 9 colony-forming units/d) (n = 151), or placebo (n = 168) from birth until day 30 of life (day 45 for neonates Main Outcome Measure First episode of late-onset sepsis, ie, sepsis occurring more than 72 hours after birth with isolation of any pathogen from blood or from peritoneal or cerebrospinal fluid. Results Demographic, clinical, and management characteristics of the 3 groups were similar, including type of feeding and intake of maternal milk. Incidence of late-onset sepsis was significantly lower in the BLF and BLF plus LGG groups (9/153 [5.9%] and 7/151 [4.6%], respectively) than in the control group receiving placebo (29/168 [17.3%]) (risk ratio, 0.34; 95% confidence interval, 0.17-0.70; P = .002 for BLF vs control and risk ratio, 0.27; 95% confidence interval, 0.12-0.60; P Conclusion Compared with placebo, BLF supplementation alone or in combination with LGG reduced the incidence of a first episode of late-onset sepsis in VLBW neonates. Trial Registration isrctn.org Identifier: ISRCTN53107700

441 citations

Journal ArticleDOI
Stephen S Lim1, Kate Allen1, Zulfiqar A Bhutta2, Zulfiqar A Bhutta3  +695 moreInstitutions (42)
TL;DR: The analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 highlights the importance of income, education, and fertility as drivers of health improvement but also emphasises that investments in these areas alone will not be sufficient.

441 citations

Journal ArticleDOI
TL;DR: The advanced interferometer network will herald a new era in observational astronomy, and there is a very strong science case to go beyond the advanced detector network and build detectors that operate in a frequency range from 1 Hz to 10 kHz, with sensitivity a factor 10 better in amplitude as discussed by the authors.
Abstract: The advanced interferometer network will herald a new era in observational astronomy. There is a very strong science case to go beyond the advanced detector network and build detectors that operate in a frequency range from 1 Hz to 10 kHz, with sensitivity a factor 10 better in amplitude. Such detectors will be able to probe a range of topics in nuclear physics, astronomy, cosmology and fundamental physics, providing insights into many unsolved problems in these areas.

441 citations

Journal ArticleDOI
TL;DR: It is shown, using theory and numerical simulation, that the landscape is much rougher than is classically assumed and undergoes a 'roughness transition' to fractal basins, which brings about isostaticity and marginal stability on approaching jamming.
Abstract: Glasses are amorphous solids whose constituent particles are caged by their neighbors and thus cannot flow. This sluggishness is often ascribed to the free energy landscape containing multiple minima (basins) separated by high barriers. Here we show, using theory and numerical simulation, that the landscape is much rougher than is classically assumed. Deep in the glass, it undergoes a "roughness transition" to fractal basins. This brings about isostaticity at jamming and marginality of glassy states near jamming. Critical exponents for the basin width, the weak force distribution, and the spatial spread of quasi-contacts at jamming can be analytically determined. Their value is found to be compatible with numerical observations. This advance therefore incorporates the jamming transition of granular materials into the framework of glass theory. Because temperature and pressure control which features of the landscape are experienced, glass mechanics and transport are expected to reflect the features of the topology we discuss here. Hitherto mysterious properties of low-temperature glasses could be explained by this approach.

441 citations

Journal ArticleDOI
Yashar Akrami1, Frederico Arroja2, M. Ashdown3, J. Aumont4  +187 moreInstitutions (59)
TL;DR: In this paper, the Planck full-mission cosmic microwave background (CMB) temperature and E-mode polarization maps were used to obtain constraints on primordial non-Gaussianity.
Abstract: We analyse the Planck full-mission cosmic microwave background (CMB) temperature and E-mode polarization maps to obtain constraints on primordial non-Gaussianity (NG). We compare estimates obtained from separable template-fitting, binned, and optimal modal bispectrum estimators, finding consistent values for the local, equilateral, and orthogonal bispectrum amplitudes. Our combined temperature and polarization analysis produces the following final results: $f_{NL}^{local}$ = −0.9 ± 5.1; $f_{NL}^{equil}$ = −26 ± 47; and $f_{NL}^{ortho}$ = −38 ± 24 (68% CL, statistical). These results include low-multipole (4 ≤ l < 40) polarization data that are not included in our previous analysis. The results also pass an extensive battery of tests (with additional tests regarding foreground residuals compared to 2015), and they are stable with respect to our 2015 measurements (with small fluctuations, at the level of a fraction of a standard deviation, which is consistent with changes in data processing). Polarization-only bispectra display a significant improvement in robustness; they can now be used independently to set primordial NG constraints with a sensitivity comparable to WMAP temperature-based results and they give excellent agreement. In addition to the analysis of the standard local, equilateral, and orthogonal bispectrum shapes, we consider a large number of additional cases, such as scale-dependent feature and resonance bispectra, isocurvature primordial NG, and parity-breaking models, where we also place tight constraints but do not detect any signal. The non-primordial lensing bispectrum is, however, detected with an improved significance compared to 2015, excluding the null hypothesis at 3.5σ. Beyond estimates of individual shape amplitudes, we also present model-independent reconstructions and analyses of the Planck CMB bispectrum. Our final constraint on the local primordial trispectrum shape is $g_{NL}^{local}$ = (−5.8 ± 6.5) × 10$^4$ (68% CL, statistical), while constraints for other trispectrum shapes are also determined. Exploiting the tight limits on various bispectrum and trispectrum shapes, we constrain the parameter space of different early-Universe scenarios that generate primordial NG, including general single-field models of inflation, multi-field models (e.g. curvaton models), models of inflation with axion fields producing parity-violation bispectra in the tensor sector, and inflationary models involving vector-like fields with directionally-dependent bispectra. Our results provide a high-precision test for structure-formation scenarios, showing complete agreement with the basic picture of the ΛCDM cosmology regarding the statistics of the initial conditions, with cosmic structures arising from adiabatic, passive, Gaussian, and primordial seed perturbations.

441 citations


Authors

Showing all 62745 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Gregory Y.H. Lip1693159171742
Peter A. R. Ade1621387138051
H. Eugene Stanley1541190122321
Suvadeep Bose154960129071
P. de Bernardis152680117804
Bart Staels15282486638
Alessandro Melchiorri151674116384
Andrew H. Jaffe149518110033
F. Piacentini149531108493
Subir Sarkar1491542144614
Albert Bandura148255276143
Carlo Rovelli1461502103550
Robert C. Gallo14582568212
R. Kowalewski1431815135517
Network Information
Related Institutions (5)
University of Padua
114.8K papers, 3.6M citations

98% related

University of Bologna
115.1K papers, 3.4M citations

97% related

University of Milan
139.7K papers, 4.6M citations

97% related

University of Turin
77.9K papers, 2.4M citations

97% related

Tel Aviv University
115.9K papers, 3.9M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023405
20221,106
20219,796
20209,753
20198,332
20187,615