Sapienza University of Rome

About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.

Millimeter-wave access and backhauling: the solution to the exponential data traffic increase in 5G mobile communications systems?

Abstract: The exponential increase of mobile data traffic requires disrupting approaches for the realization of future 5G systems. In this article, we overview the technologies that will pave the way for a novel cellular architecture that integrates high-data-rate access and backhaul networks based on millimeter-wave frequencies (57-66, 71-76, and 81-86 GHz). We evaluate the feasibility of short- and medium-distance links at these frequencies and analyze the requirements from the transceiver architecture and technology, antennas, and modulation scheme points of view. Technical challenges are discussed, and design options highlighted; finally, a performance evaluation quantifies the benefits of millimeter- wave systems with respect to current cellular technologies.

Neutrophil diversity and plasticity in tumour progression and therapy.

Abstract: Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important component of the tumour microenvironment. Here, they can exert dual functions. TANs can be part of tumour-promoting inflammation by driving angiogenesis, extracellular matrix remodelling, metastasis and immunosuppression. Conversely, neutrophils can also mediate antitumour responses by direct killing of tumour cells and by participating in cellular networks that mediate antitumour resistance. Neutrophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment. Myeloid checkpoints as well as the tumour and tissue contexture shape neutrophil function in response to conventional therapies and immunotherapy. We surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.